Recombinant Human USP2 Protein, His-tagged


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Recombinant Human USP2 Protein, His-tagged

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Cat.No. : USP2-092H
Product Overview : Recombinant C-terminally Histidine-tagged human USP2 enzyme (active catalytic domain, 259-605) was purified from E. coli.
Description : This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 40.9 kDa
Protein length : 259-605
Purity : ≥95% as determined by SDS-PAGE
Unit Definition : One unit is defined as the amount of USP2 enzyme required to produce 1 pmol of AMC per minute at room temperature in 50 mM HEPES, pH 7.8, 0.5 mM EDTA, 1 mM DTT, and 0.2% CHAPS.
Stability : ≥ 2 years
Storage : At -80 centigrade.
Storage Buffer : 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 1 mM DTT, and 0.1 mM EDTA
SDS-PAGE analysis of USP2 :

Lane 1: MW Markers
Lane 2: USP2 (1 μg)
Lane 3: USP2 (2 μg)
Lane 4: USP2 (4 μg)

Figure :

Gene Name : USP2 ubiquitin specific peptidase 2 [ Homo sapiens (human) ]
Official Symbol : USP2
Synonyms : USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin specific protease 12; ubiquitin specific protease 9; ubiquitin thioesterase 2; ubiquitin-specific-processing protease 2; EC
Gene ID : 9099
mRNA Refseq : NM_004205
Protein Refseq : NP_004196
MIM : 604725
UniProt ID : O75604
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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