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Recombinant Human USP2, His-tagged

Cat.No. : USP2-153H
Product Overview : Recombinant Human USP2core protein, fused with His6 tag, was expressed in E. coli.
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Description : USP2 core represents the common catalytic core domain of the two isoforms of USP2, USP2a and USP2b. In vitro studies revealed that the USP2 core was able to deubiquitylate high molecular weight proteins from testis extracts and cleave Ub-PLA2 with good efficiency.
Source : E. coli
Species : Human
Tag : His
Form : Liquid, 50mM Hepes, pH8, 150mM NaCl, 5mM DTT, 10% glycerol
Molecular Mass : 40kDa
Storage : Store at -80°C, avoiding repeated freeze-thaw cycles.
Gene Name : USP2 ubiquitin specific peptidase 2 [ Homo sapiens ]
Official Symbol : USP2
Synonyms : USP2; ubiquitin specific peptidase 2; ubiquitin specific protease 2; ubiquitin carboxyl-terminal hydrolase 2; UBP41; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2; USP9;
Gene ID : 9099
mRNA Refseq : NM_001243759
Protein Refseq : NP_001230688
MIM : 604725
UniProt ID : O75604
Chromosome Location : 11q23.3
Pathway : TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;
Function : cyclin binding; cysteine-type endopeptidase activity; identical protein binding; metal ion binding; peptidase activity; protein binding; ubiquitin protein ligase binding; ubiquitin thiolesterase activity; ubiquitin thiolesterase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can USP2 serve as a biomarker for certain diseases? 03/17/2022

It's possible. Elevated levels of USP2 have been associated with certain cancers and metabolic disorders, suggesting its potential as a biomarker for disease diagnosis and prognosis.

Are there any ongoing clinical trials targeting USP2 for diabetes treatment? 09/02/2021

There's research interest in exploring USP2 inhibitors to potentially improve insulin sensitivity and manage diabetes, but clinical trials in this area are still in early stages.

Are there any clinical studies exploring the use of USP2 inhibitors in cancer treatment? 09/01/2020

Yes, several studies are investigating USP2 inhibitors as potential therapeutic agents in cancer treatment to target specific pathways involved in tumor growth.

How does USP2 impact insulin sensitivity and diabetes? 05/27/2020

USP2 has been shown to regulate insulin signaling by deubiquitinating proteins involved in insulin receptor signaling pathways. Dysregulation of USP2 may contribute to insulin resistance in diabetes.

Can USP2 be a potential therapeutic target for drug development? 02/23/2018

Yes, due to its role in regulating protein stability, USP2 is being considered as a potential therapeutic target for drug development, especially in cancer and other diseases involving dysregulated protein turnover.

Customer Reviews (3)

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Reviews
09/14/2022

    Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

    03/09/2016

      With the USP2 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

      02/03/2016

        The USP2 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

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