Active Recombinant human USP2 protein, FLAG-tagged

Species :	Human
Source :	Sf9 Cells
Tag :	Flag
Protein Length :	2-605(end)
Description :	This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Form :	Aqueous buffer solution
Bio-activity :	8.9 pmole/min/µg
Molecular Mass :	69 kDa
Storage :	At least 6 months at –80°C.
Storage Buffer :	40mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 100ug/mL FLAG peptide and 20% glycerol.
Shipping :	-80°C
Warning :	Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein BSA (0.1 – 0.5%).

Gene Name	USP2 ubiquitin specific peptidase 2 [ Homo sapiens (human) ]
Official Symbol	USP2
Synonyms	Ubiquitin-Specific Protease 2, UPB41, USP-2
Gene ID	9099
mRNA Refseq	NM_004205
Protein Refseq	NP_004196.4
MIM	604725
UniProt ID	O75604