Active Recombinant human USP2 protein, FLAG-tagged

• Cat.No.: USP2-320H
• Product Overview: Recombinant human USP2 protein, FLAG-tagged was expressed in baculovirus-infected Sf9 cell

Specification

• Description: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: Sf9 cell
• Species: Human
• Tag: FLAG
• Form: Aqueous buffer solution
• Bio-activity: 8.9 pmole/min/µg
• Molecular Mass: 69 kDa
• Protein length: 2-605(end)
• Storage: At least 6 months at –80°C.
• Storage Buffer: 40mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 100ug/mL FLAG peptide and 20% glycerol.
• Shipping: -80°C
• Warning: Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein BSA (0.1 – 0.5%).

Gene Information

• Gene Name: USP2 ubiquitin specific peptidase 2 [ Homo sapiens (human) ]
• Official Symbol: USP2
• Synonyms: Ubiquitin-Specific Protease 2, UPB41, USP-2
• Gene ID: 9099
• mRNA Refseq: NM_004205
• Protein Refseq: NP_004196.4
• MIM: 604725
• UniProt ID: O75604