• Official Full Name

    WD repeat domain 77

  • Background

    WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008]
  • Synonyms

    WDR77; WD repeat domain 77; p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50; methylosome protein 50; androgen receptor cofactor p44; WD repeat-containing protein 77;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Price
    Human WDR77-12H Recombinant Human WDR77 protein, His-tagged E.coli His
    Human WDR77-318H Recombinant Human WDR77 protein, GST-tagged Insect Cell GST
    Human WDR77-1049H Recombinant Human WDR77 Protein, His-SUMO-tagged E.coli His/SUMO
    Human WDR77-333HCL Recombinant Human WDR77 293 Cell Lysate HEK293 N/A
    Human WDR77-4438H Recombinant Human WDR77 Protein, GST-tagged Wheat Germ GST
    Human WDR77-6136HF Recombinant Full Length Human WDR77 Protein, GST-tagged In Vitro Cell Free System GST
    Mouse WDR77-18503M Recombinant Mouse WDR77 Protein Mammalian Cell His
    Mouse WDR77-10150M Recombinant Mouse WDR77 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse WDR77-10150M-B Recombinant Mouse WDR77 Protein Pre-coupled Magnetic Beads HEK293
    Rat WDR77-6576R Recombinant Rat WDR77 Protein Mammalian Cell His
    Rat WDR77-6232R Recombinant Rat WDR77 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat WDR77-6232R-B Recombinant Rat WDR77 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque WDR77-5205R Recombinant Rhesus monkey WDR77 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque WDR77-5018R Recombinant Rhesus Macaque WDR77 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque WDR77-5018R-B Recombinant Rhesus Macaque WDR77 Protein Pre-coupled Magnetic Beads HEK293
    Zebrafish WDR77-10819Z Recombinant Zebrafish WDR77 Mammalian Cell His
    Chicken WDR77-2605C Recombinant Chicken WDR77 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    WDR77 involved in several pathways and played different roles in them. We selected most pathways WDR77 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR77 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymesKDM2B;KDM2AA;ING5A;HMG20B;CHD4A;SMARCB1B;JHDM1D;TADA1;TAF6L
    Chromatin organizationC20orf20;MBD3A;JADE1;EHMT2;SMARCB1B;GATAD2B;PRDM16;KDM5C;KDM6AL
    Gene ExpressionZNF701;ZFP36L1B;CTDP1;ZNF773;ZNF786;ZNF543;ZKSCAN4;LAMTOR1;ZNF750
    Metabolism of non-coding RNAPEAK1;SNUPN;CLNS1A;DDX20;PRMT5;WDR77
    RMTs methylate histone argininesSMARCA4;SMARCA2;PRMT6;WDR77;SMARCB1;PRMT5;SMARCD1;SMARCC2;SMARCE1
    Signaling events mediated by HDAC Class IGATA2;SIRT7;NR2C1;GATA1;PRMT5;SIRT4;TFCP2;FKBP3;SIRT2
    snRNP AssemblyPEAK1;SNUPN;DDX20;WDR77;CLNS1A

    WDR77 has several biochemical functions, for example, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR77 itself. We selected most functions WDR77 had, and list some proteins which have the same functions with WDR77. You can find most of the proteins on our site.

    Function Related Protein
    ligand-dependent nuclear receptor transcription coactivator activityWDR77;HMGA1-RS1;MED24;NCOA3;HELZ2;SLC30A9;SRA1;ZCCHC18;PUS1

    WDR77 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR77 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR77.

    PRMT5; Cct3; Hnrnph1; Ccnd1; YWHAQ; YWHAB; YWHAZ; CTDP1; ZNF207; AQR; PQBP1; BAG2; SNRPC; HNRNPM

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