WDR77

  • Official Full Name

    WD repeat domain 77

  • Overview

    WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008]
  • Synonyms

    WDR77; WD repeat domain 77; p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50; methylosome protein 50; androgen receptor cofactor p44; WD repeat-containing protein 77;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WDR77-12H Recombinant Human WDR77 protein, His-tagged E.coli His
Human WDR77-318H Recombinant Human WDR77 protein, GST-tagged Insect Cell GST
Human WDR77-1049H Recombinant Human WDR77 Protein, His-SUMO-tagged E.coli His/SUMO
Human WDR77-333HCL Recombinant Human WDR77 293 Cell Lysate HEK293 N/A
Human WDR77-4438H Recombinant Human WDR77 Protein, GST-tagged Wheat Germ GST
Human WDR77-6136HF Recombinant Full Length Human WDR77 Protein, GST-tagged In Vitro Cell Free System GST 342 amino acids
Mouse WDR77-18503M Recombinant Mouse WDR77 Protein Mammalian Cell His
Mouse WDR77-10150M Recombinant Mouse WDR77 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WDR77-10150M-B Recombinant Mouse WDR77 Protein Pre-coupled Magnetic Beads HEK293
Rat WDR77-6576R Recombinant Rat WDR77 Protein Mammalian Cell His
Rat WDR77-6232R Recombinant Rat WDR77 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat WDR77-6232R-B Recombinant Rat WDR77 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque WDR77-5205R Recombinant Rhesus monkey WDR77 Protein, His-tagged Mammalian Cell His
Rhesus Macaque WDR77-5018R Recombinant Rhesus Macaque WDR77 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque WDR77-5018R-B Recombinant Rhesus Macaque WDR77 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish WDR77-10819Z Recombinant Zebrafish WDR77 Mammalian Cell His
Chicken WDR77-2605C Recombinant Chicken WDR77 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

WDR77 involved in several pathways and played different roles in them. We selected most pathways WDR77 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR77 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesACTL6A;SMARCA2;PRMT6;PBRM1;PRMT5;C17orf81;ELP4;RBBP7;EP400
Chromatin organizationKANSL2;CSRP2BP;DPY30;MTA2;TADA3;PRMT7;KDM2AA;KDM5B;ATXN7L3
Gene ExpressionZNF584;DPY19L2;A1CF;TUBB3;ZNF583;ADARB1A;TCEB3;MED20;CDK9
Metabolism of non-coding RNACLNS1A;WDR77;PEAK1;PRMT5;DDX20;SNUPN
RMTs methylate histone argininesSMARCD3B;PRMT6;SMARCA2;SMARCA4;ACTL6B;PRMT7;ARID2;SMARCC1B;SMARCB1B
Signaling events mediated by HDAC Class IGATA2;SIRT2;GATA1;SIRT4;FKBP3;MXD1;NR2C1;WDR77;SIRT7
snRNP AssemblyPEAK1;SNUPN;WDR77;CLNS1A;DDX20

WDR77 has several biochemical functions, for example, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR77 itself. We selected most functions WDR77 had, and list some proteins which have the same functions with WDR77. You can find most of the proteins on our site.

Function Related Protein
ligand-dependent nuclear receptor transcription coactivator activityPPARG;MED24;DCAF6;SS18;PPARGC1A;ENY2;MED1;HMGA1-RS1;PUS1
protein bindingLRP4;Clec4n;RFWD3;EPS15;SPAG9;HMGB3;IL33;CXCL9;TIMP1

WDR77 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR77 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR77.

PRMT5; Cct3; Hnrnph1; Ccnd1; YWHAQ; YWHAB; YWHAZ; CTDP1; ZNF207; AQR; PQBP1; BAG2; SNRPC; HNRNPM

  • Q&As
  • Reviews

Q&As (7)

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What role does WDR77 play in cancer development and progression? 09/15/2022

WDR77 can influence cancer progression by regulating cell growth and division.

What is the impact of WDR77 dysregulation in hormonal cancers, such as prostate cancer? 02/11/2022

WDR77 dysregulation is particularly significant in hormonal cancers, impacting androgen receptor signaling.

How does WDR77 contribute to the regulation of gene expression and protein synthesis? 10/07/2020

It plays a role in gene expression by participating in the formation of the spliceosome and ribosome assembly.

What potential therapeutic strategies could target WDR77 in cancer treatment? 03/01/2020

Targeting WDR77 in therapy could provide new avenues for treating cancers, especially hormone-driven cancers like prostate cancer.

How does WDR77 interact with other proteins and signaling pathways in the cell? 11/02/2019

WDR77 interacts with molecular chaperones and is involved in multiple signaling pathways, influencing cell cycle and apoptosis.

What is the primary function of WDR77 in cellular processes? 11/24/2018

WDR77 is involved in various cellular functions, including RNA processing and ribosome biogenesis.

How do genetic alterations in WDR77 affect its function and contribute to disease development? 04/08/2018

Mutations in WDR77 can disrupt its normal functions, potentially leading to uncontrolled cell proliferation and cancer.

Customer Reviews (3)

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Reviews
06/09/2019

    Crucial for decision-making. Accurate and efficient protein analysis.

    10/04/2018

      Exceeds research standards. Trusted for accurate data.

      03/29/2017

        Dependable partner in our experiments. Consistently meets expectations.

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