WDR77
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Official Full Name
WD repeat domain 77
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Overview
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008] -
Synonyms
WDR77; WD repeat domain 77; p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50; methylosome protein 50; androgen receptor cofactor p44; WD repeat-containing protein 77;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
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- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- SUMO
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
WDR77 involved in several pathways and played different roles in them. We selected most pathways WDR77 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR77 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | MTA1;SMARCA2;MBIP;ANO9A;MSL3;PHF20B;SMYD2;PHF8;ARID1A |
| Chromatin organization | TADA1;SMARCD3B;KDM2AA;ING4;SMARCD1;EPC1;BRMS1;KAT8;MCRS1 |
| Gene Expression | HNRNPH1L;ZNF771;CCNT2B;ASZ1;NR5A1;ZNF554;ZNF274;ZNF729;ZNF563 |
| Metabolism of non-coding RNA | PRMT5;WDR77;CLNS1A;DDX20;SNUPN;PEAK1 |
| RMTs methylate histone arginines | PRMT7;SMARCC1B;SMARCB1B;SMARCD1;SMARCC1;SMARCA2;SMARCD3B;SMARCE1;WDR77 |
| Signaling events mediated by HDAC Class I | TFCP2;GATA2;SIRT5;NR2C1;SIRT2;SIRT4;FKBP3;SIRT7;PRMT5 |
| snRNP Assembly | DDX20;PEAK1;WDR77;CLNS1A;SNUPN |
WDR77 has several biochemical functions, for example, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR77 itself. We selected most functions WDR77 had, and list some proteins which have the same functions with WDR77. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-dependent nuclear receptor transcription coactivator activity | ZCCHC12;TADA3;SFR1;MED17;LRP2BP;CCDC62;RBM14;CALCOCO1;NCOA2 |
| protein binding | C4orf26;STT3A;TUB;IFT57;NSF;LLGL1;MCM2;CCDC92;KCNH2 |
WDR77 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR77 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR77.
PRMT5; Cct3; Hnrnph1; Ccnd1; YWHAQ; YWHAB; YWHAZ; CTDP1; ZNF207; AQR; PQBP1; BAG2; SNRPC; HNRNPM
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Q&As (7)
Ask a questionWDR77 can influence cancer progression by regulating cell growth and division.
WDR77 dysregulation is particularly significant in hormonal cancers, impacting androgen receptor signaling.
It plays a role in gene expression by participating in the formation of the spliceosome and ribosome assembly.
Targeting WDR77 in therapy could provide new avenues for treating cancers, especially hormone-driven cancers like prostate cancer.
WDR77 interacts with molecular chaperones and is involved in multiple signaling pathways, influencing cell cycle and apoptosis.
WDR77 is involved in various cellular functions, including RNA processing and ribosome biogenesis.
Mutations in WDR77 can disrupt its normal functions, potentially leading to uncontrolled cell proliferation and cancer.
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