Recombinant Human WDR77 Protein, GST-tagged

• Cat.No.: WDR77-4438H
• Product Overview: Human MEP50 full-length ORF ( AAH01679, 1 a.a. - 342 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 63.36 kDa
• AA Sequence: MRKETPPPLVPPAAREWNLPPNAPA CMERQLEAARYRSDGALLLGASSLS GRCWAGSLWLFKDPCAAPNEGFCSA GVQTEAGVADLTWVGERGILVASDS GAVELWELDENETLIVSKFCKYEHD DIVSTVSVLSSGTQAVSGSKDICIK VWDLAQQVVLSSYRAHAAQVTCVAA SPHKDSVFLSCSEDNRILLWDTRCP KPASQIGCSAPGYLPTSLAWHPQQS EVFVFGDENGTVSLVDTKSTSCVLS SAVHSQCVTGLVFSPHSVPFLASLS EDCSLAVLDSSLSELFRSQAHRDFV RDATWSPLNHSLLTTVGWDHQVVHH VVPTEPLPAPGPASVTE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: WDR77 WD repeat domain 77 [ Homo sapiens ]
• Official Symbol: WDR77
• Synonyms: WDR77; WD repeat domain 77; methylosome protein 50; MEP50; androgen receptor cofactor p44; WD repeat-containing protein 77; p44; MEP-50; HKMT1069; Nbla10071; p44/Mep50; MGC2722; RP11-552M11.3
• Gene ID: 79084
• mRNA Refseq: NM_024102
• Protein Refseq: NP_077007
• MIM: 611734
• UniProt ID: Q9BQA1