Recombinant Human WDR77 Protein, His-SUMO-tagged

• Cat.No.: WDR77-1049H
• Product Overview: Recombinant Human WDR77 Protein (1-312aa) was expressed in E. coli with N-terminal His-SUMO tag.

Specification

• Source: E. coli
• Species: Human
• Tag: His&SUMO
• Form: Tris-based buffer, 50% glycerol.
• Molecular Mass: 49.6 kDa
• AA Sequence: MRKETPPPLVPPAAREWNLPPNAPA CMERQLEAARYRSDGALLLGASSLS GRCWAGSLWLFKDPCAAPNEGFCSA GVQTEAGVADLTWVGERGILVASDS GAVELWELDENETLIVSKFCKYEHD DIVSTVSVLSSGTQAVSGSKDICIK VWDLAQQVVLSSYRAHAAQVTCVAA SPHKDSVFLSCSEDNRILLWDTRCP KPASQIGCSAPGYLPTSLAWHPQQS EVFVFGDENGTVSLVDTKSTSCVLS SAVHSQCVTGLVFSPHSVPFLASLS EDCSLAVLDSSLSELFRSQAHRDFV RDATWSPLNHSL
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: The shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Protein length: 1-312

Gene Information

• Gene Name: WDR77 WD repeat domain 77 [ Homo sapiens ]
• Official Symbol: WDR77
• Synonyms: WDR77; WD repeat domain 77; methylosome protein 50; MEP50; androgen receptor cofactor p44; WD repeat-containing protein 77; p44; MEP-50; HKMT1069; Nbla10071; p44/Mep50; MGC2722; RP11-552M11.3
• Gene ID: 79084
• mRNA Refseq: NM_024102
• Protein Refseq: NP_077007
• MIM: 611734
• UniProt ID: Q9BQA1

Reviews

06/09/2019

Crucial for decision-making. Accurate and efficient protein analysis.

10/04/2018

Exceeds research standards. Trusted for accurate data.

03/29/2017

Dependable partner in our experiments. Consistently meets expectations.

Q&As

What role does WDR77 play in cancer development and progression?

WDR77 can influence cancer progression by regulating cell growth and division.

What is the impact of WDR77 dysregulation in hormonal cancers, such as prostate cancer?

WDR77 dysregulation is particularly significant in hormonal cancers, impacting androgen receptor signaling.

How does WDR77 contribute to the regulation of gene expression and protein synthesis?

It plays a role in gene expression by participating in the formation of the spliceosome and ribosome assembly.

What potential therapeutic strategies could target WDR77 in cancer treatment?

Targeting WDR77 in therapy could provide new avenues for treating cancers, especially hormone-driven cancers like prostate cancer.

How does WDR77 interact with other proteins and signaling pathways in the cell?

WDR77 interacts with molecular chaperones and is involved in multiple signaling pathways, influencing cell cycle and apoptosis.

What is the primary function of WDR77 in cellular processes?

WDR77 is involved in various cellular functions, including RNA processing and ribosome biogenesis.

How do genetic alterations in WDR77 affect its function and contribute to disease development?

Mutations in WDR77 can disrupt its normal functions, potentially leading to uncontrolled cell proliferation and cancer.