Recombinant Full Length Human WDR77 Protein, GST-tagged

Cat.No. : WDR77-6136HF
Product Overview : Human MEP50 full-length ORF ( AAH01679, 1 a.a. - 342 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM
Source : In Vitro Cell Free System
Species : Human
Tag : GST
Molecular Mass : 63.36 kDa
Protein Length : 342 amino acids
AA Sequence : MRKETPPPLVPPAAREWNLPPNAPA CMERQLEAARYRSDGALLLGASSLS GRCWAGSLWLFKDPCAAPNEGFCSA GVQTEAGVADLTWVGERGILVASDS GAVELWELDENETLIVSKFCKYEHD DIVSTVSVLSSGTQAVSGSKDICIK VWDLAQQVVLSSYRAHAAQVTCVAA SPHKDSVFLSCSEDNRILLWDTRCP KPASQIGCSAPGYLPTSLAWHPQQS EVFVFGDENGTVSLVDTKSTSCVLS SAVHSQCVTGLVFSPHSVPFLASLS EDCSLAVLDSSLSELFRSQAHRDFV RDATWSPLNHSLLTTVGWDHQVVHH VVPTEPLPAPGPASVTE
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : WDR77 WD repeat domain 77 [ Homo sapiens ]
Official Symbol : WDR77
Synonyms : WDR77; WD repeat domain 77; methylosome protein 50; MEP50; androgen receptor cofactor p44; WD repeat-containing protein 77; p44; MEP-50; HKMT1069; Nbla10071; p44/Mep50; MGC2722; RP11-552M11.3;
Gene ID : 79084
mRNA Refseq : NM_024102
Protein Refseq : NP_077007
MIM : 611734
UniProt ID : Q9BQA1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does WDR77 play in cancer development and progression? 09/15/2022

WDR77 can influence cancer progression by regulating cell growth and division.

What is the impact of WDR77 dysregulation in hormonal cancers, such as prostate cancer? 02/11/2022

WDR77 dysregulation is particularly significant in hormonal cancers, impacting androgen receptor signaling.

How does WDR77 contribute to the regulation of gene expression and protein synthesis? 10/07/2020

It plays a role in gene expression by participating in the formation of the spliceosome and ribosome assembly.

What potential therapeutic strategies could target WDR77 in cancer treatment? 03/01/2020

Targeting WDR77 in therapy could provide new avenues for treating cancers, especially hormone-driven cancers like prostate cancer.

How does WDR77 interact with other proteins and signaling pathways in the cell? 11/02/2019

WDR77 interacts with molecular chaperones and is involved in multiple signaling pathways, influencing cell cycle and apoptosis.

What is the primary function of WDR77 in cellular processes? 11/24/2018

WDR77 is involved in various cellular functions, including RNA processing and ribosome biogenesis.

How do genetic alterations in WDR77 affect its function and contribute to disease development? 04/08/2018

Mutations in WDR77 can disrupt its normal functions, potentially leading to uncontrolled cell proliferation and cancer.

Customer Reviews (3)

Write a review
Reviews
06/09/2019

    Crucial for decision-making. Accurate and efficient protein analysis.

    10/04/2018

      Exceeds research standards. Trusted for accurate data.

      03/29/2017

        Dependable partner in our experiments. Consistently meets expectations.

        Ask a Question for All WDR77 Products

        Required fields are marked with *

        My Review for All WDR77 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends