Recombinant Human WDR77 protein, His-tagged

Cat.No. : WDR77-12H
Product Overview : Recombinant Human WDR77 fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Form : 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles.
Molecular Mass : 36.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : WDR77 WD repeat domain 77 [ Homo sapiens ]
Official Symbol : WDR77
Synonyms : WDR77; WD repeat domain 77; methylosome protein 50; MEP50; androgen receptor cofactor p44; WD repeat-containing protein 77; p44; MEP-50; HKMT1069; Nbla10071; p44/Mep50; MGC2722; RP11-552M11.3;
Gene ID : 79084
mRNA Refseq : NM_024102
Protein Refseq : NP_077007
MIM : 611734
UniProt ID : Q9BQA1
Chromosome Location : 1p13.2
Pathway : Gene expression, organism-specific biosystem; Metabolism of non-coding RNA, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; snRNP Assembly, organism-specific biosystem;
Function : ligand-dependent nuclear receptor transcription coactivator activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does WDR77 play in cancer development and progression? 09/15/2022

WDR77 can influence cancer progression by regulating cell growth and division.

What is the impact of WDR77 dysregulation in hormonal cancers, such as prostate cancer? 02/11/2022

WDR77 dysregulation is particularly significant in hormonal cancers, impacting androgen receptor signaling.

How does WDR77 contribute to the regulation of gene expression and protein synthesis? 10/07/2020

It plays a role in gene expression by participating in the formation of the spliceosome and ribosome assembly.

What potential therapeutic strategies could target WDR77 in cancer treatment? 03/01/2020

Targeting WDR77 in therapy could provide new avenues for treating cancers, especially hormone-driven cancers like prostate cancer.

How does WDR77 interact with other proteins and signaling pathways in the cell? 11/02/2019

WDR77 interacts with molecular chaperones and is involved in multiple signaling pathways, influencing cell cycle and apoptosis.

What is the primary function of WDR77 in cellular processes? 11/24/2018

WDR77 is involved in various cellular functions, including RNA processing and ribosome biogenesis.

How do genetic alterations in WDR77 affect its function and contribute to disease development? 04/08/2018

Mutations in WDR77 can disrupt its normal functions, potentially leading to uncontrolled cell proliferation and cancer.

Customer Reviews (3)

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Reviews
06/09/2019

    Crucial for decision-making. Accurate and efficient protein analysis.

    10/04/2018

      Exceeds research standards. Trusted for accurate data.

      03/29/2017

        Dependable partner in our experiments. Consistently meets expectations.

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