Recombinant Human WDR77 protein, His-tagged

• Cat.No.: WDR77-12H
• Product Overview: Recombinant Human WDR77 fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles.
• Molecular Mass: 36.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: WDR77 WD repeat domain 77 [ Homo sapiens ]
• Official Symbol: WDR77
• Synonyms: WDR77; WD repeat domain 77; methylosome protein 50; MEP50; androgen receptor cofactor p44; WD repeat-containing protein 77; p44; MEP-50; HKMT1069; Nbla10071; p44/Mep50; MGC2722; RP11-552M11.3
• Gene ID: 79084
• mRNA Refseq: NM_024102
• Protein Refseq: NP_077007
• MIM: 611734
• UniProt ID: Q9BQA1
• Chromosome Location: 1p13.2
• Pathway: Gene expression, organism-specific biosystem; Metabolism of non-coding RNA, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; snRNP Assembly, organism-specific biosystem;
• Function: ligand-dependent nuclear receptor transcription coactivator activity; protein binding

Reviews

06/09/2019

Crucial for decision-making. Accurate and efficient protein analysis.

10/04/2018

Exceeds research standards. Trusted for accurate data.

03/29/2017

Dependable partner in our experiments. Consistently meets expectations.

Q&As

What role does WDR77 play in cancer development and progression?

WDR77 can influence cancer progression by regulating cell growth and division.

What is the impact of WDR77 dysregulation in hormonal cancers, such as prostate cancer?

WDR77 dysregulation is particularly significant in hormonal cancers, impacting androgen receptor signaling.

How does WDR77 contribute to the regulation of gene expression and protein synthesis?

It plays a role in gene expression by participating in the formation of the spliceosome and ribosome assembly.

What potential therapeutic strategies could target WDR77 in cancer treatment?

Targeting WDR77 in therapy could provide new avenues for treating cancers, especially hormone-driven cancers like prostate cancer.

How does WDR77 interact with other proteins and signaling pathways in the cell?

WDR77 interacts with molecular chaperones and is involved in multiple signaling pathways, influencing cell cycle and apoptosis.

What is the primary function of WDR77 in cellular processes?

WDR77 is involved in various cellular functions, including RNA processing and ribosome biogenesis.

How do genetic alterations in WDR77 affect its function and contribute to disease development?

Mutations in WDR77 can disrupt its normal functions, potentially leading to uncontrolled cell proliferation and cancer.