wisp2
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  • Official Full Name
  • WNT1 inducible signaling pathway protein 2
  • Background
  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
  • Synonyms
  • WISP2; WNT1 inducible signaling pathway protein 2; WNT1-inducible-signaling pathway protein 2; CCN5; CT58; CTGF L; CCN family member 5; Connective tissue growth factor like protein; Connective tissue growth factor related protein 58; Connective tissue growth factor-like protein; Connective tissue growth factor-related protein 58; CTGF-L; WISP 2; WISP-2; WISP2_HUMAN; OTTHUMP00000031770; OTTHUMP00000063227; wnt-1 signaling pathway protein 2
Cat.#:WISP2-1166MTag:His-SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse WISP2 Protein (24-251 aa), His-SUMO-tagged
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Cat.#:WISP2-1754MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse WISP2 Protein (24-251 aa), His-tagged
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Cat.#:Wisp2-591RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Wisp2 Protein, His-tagged
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Cat.#:WISP2-30865THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WISP2
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Cat.#:WISP2-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WISP2 protein, His-tagged
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Cat.#:WISP2-3734HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WISP2, GST-tagged
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Cat.#:WISP2-932HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT1 Inducible Signaling Pathway Protein 2
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Cat.#:WISP2-31RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Wisp2 protein, His-tagged
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Cat.#:WISP2-6595RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat WISP2 Protein
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Cat.#:WISP2-7845ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WISP2
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Cat.#:WISP2-644HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT1 Inducible Signaling Pathway Protein 2
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Cat.#:WISP2-307HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WISP2 293 Cell Lysate
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Protein Function

WISP2 has several biochemical functions, for example, heparin binding, insulin-like growth factor binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WISP2 itself. We selected most functions WISP2 had, and list some proteins which have the same functions with WISP2. You can find most of the proteins on our site.
Function
Related Protein
Function heparin binding
Related Protein PLA2G5; BSPH1; PRELP; GM4980; ADAMTS8; PTN; VTN; HBEGF; ADAMTS3; COL20A1
Function insulin-like growth factor binding
Related Protein KAZALD1; HTRA4; IGFBP2B; WISP1; WISP2; Igfbpl1; IGF2R; IGFBP6B; CYR61; KAZALD2
Function integrin binding
Related Protein CTGFB; ITGA6; ITGB1BP1; TNN; FERMT3; CXADR; ANXA7; P4HB; ITGB1BP2; TSPAN4

Interacting Protein

WISP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WISP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WISP2.
TFAP2A; syd; fliH; TFAP2C