Active Recombinant Human BMPR1A protein, hFc&His-tagged

• Cat.No.: BMPR1A-2678H
• Product Overview: Active Recombinant Human BMPR-1A/ALK-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Arg152) of human BMPRIA/ALK-3/CD292 (Accession #NP_004320.2) fused with an Fc, 6×His tag at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: His&Fc
• Form: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
• Bio-activity: Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2B at 1 μg/mL (100 μL/well) can bind Human BMPRIA with a linear range of 0.5-62.5 ng/mL.
• Molecular Mass: 55 kDa
• Protein length: Gln24-Arg152
• Endotoxin: < 0.1 EU/μg of the protein by LAL method.
• Purity: > 95% by SDS-PAGE.
• Storage: Store the lyophilized protein at -20°C to -80 °C for long term.
  After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

Gene Information

• Gene Name: BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ]
• Official Symbol: BMPR1A
• Synonyms: BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor R5; SKR5; 10q23del
• Gene ID: 657
• mRNA Refseq: NM_004329
• Protein Refseq: NP_004320
• MIM: 601299
• UniProt ID: P36894

Reviews

11/06/2021

The enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.

10/20/2021

When experimenting with this protein, stable and repeatable results can be obtained.

03/08/2021

This product has strict quality control and complies with relevant industry standards.

Q&As

What disease might abnormal BMPR1A levels suggest?

Abnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.

Is there a mutation type of BMPR1A?

The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How are mutations in BMPR1A detected and analyzed?

Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of BMPR1A?

Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the applications of BMPR1A in medical treatment?

BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.

What diseases can BMPR1A deficiency or aberrant expression cause?

Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.