Active Recombinant Human HBEGF Protein (86 aa)
Cat.No. : | HBEGF-385H |
Product Overview : | Recombinant Human HB-EGF produced in E. coli cells is a polypeptide chain containing 86 amino acids. A fully biologically active molecule, rhHB-EGF has a molecular mass of 14 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds to the EGF receptor with a higher affinity and has been shown to bemore mitogenic, likely due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has also been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin. Heparin-binding EGF-like growth factor has been shown to interact with NRD1, Zinc finger and BTB domain-containing protein 16 and BAG1. |
Source : | E. coli |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 0.75 ng/mL, measured in a cell proliferation assay using 3T3 cells. |
Molecular Mass : | 14 kDa, observed by reducing SDS-PAGE. |
Protein Length : | 86 |
AA Sequence : | GDLQEADLDLLRVTLSSKPQALATP NKEEHGKRKKKGKGLGKKRDPCLRK YKDFCIHGECKYVKELRAPSCICHP GYHGERCHGLSL |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE. |
Storage : | Lyophilized recombinant Human Proheparin-binding EGF-like Growth Factor (HB-EGF), remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human HB-EGF should be stable up to 1 week at 4 centigrade or up to 3 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
Gene Name : | HBEGF heparin-binding EGF-like growth factor [ Homo sapiens ] |
Official Symbol : | HBEGF |
Synonyms : | HBEGF; heparin-binding EGF-like growth factor; diphtheria toxin receptor (heparin binding epidermal growth factor like growth factor), DTR, DTS, HEGFL; proheparin-binding EGF-like growth factor; Diphtheria toxin receptor (heparin binding EGF like growth factor); heparin binding epidermal growth factor; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DTR; DTS; DTSF; HEGFL; |
Gene ID : | 1839 |
mRNA Refseq : | NM_001945 |
Protein Refseq : | NP_001936 |
MIM : | 126150 |
UniProt ID : | Q99075 |
Products Types
◆ Recombinant Protein | ||
HBEGF-4599H | Recombinant Human HBEGF Protein, GST-tagged | +Inquiry |
HBEGF-269H | Active Recombinant Human HBEGF Protein | +Inquiry |
HBEGF-1864R | Recombinant Rhesus Macaque HBEGF Protein, His (Fc)-Avi-tagged | +Inquiry |
HBEGF-4076M | Recombinant Mouse HBEGF Protein, His (Fc)-Avi-tagged | +Inquiry |
HBEGF-2455R | Recombinant Rat HBEGF Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HBEGF-551HCL | Recombinant Human HBEGF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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