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Active Recombinant Human IL12RB1 protein, Fc-tagged

Cat.No. : IL12RB1-0228H
Product Overview : Recombinant Human IL12RB1 protein(Cys24-Glu540), fused with Fc tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized Human IL-12B, His Tag at 5 μg/mL (100 μL/well) can bind Human IL-12 R beta 1, Fc Tag with a linear range of 5-78 ng/mL.
Molecular Mass : This protein carries a human IgG1 Fc tag at the C-terminus.The protein has a calculated MW of 83.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Proteinlength : Cys24-Glu540
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Protein length : Cys24-Glu540
Gene Name : IL12RB1 interleukin 12 receptor, beta 1 [ Homo sapiens ]
Official Symbol : IL12RB1
Synonyms : IL12RB1; interleukin 12 receptor, beta 1; IL12RB; interleukin-12 receptor subunit beta-1; CD212; IL-12RB1; IL-12R-beta-1; IL-12R subunit beta-1; IL-12 receptor beta component; IL-12 receptor subunit beta-1; interleukin-12 receptor beta-1 chain; IL-12R-BETA1; MGC34454;
Gene ID : 3594
mRNA Refseq : NM_005535
Protein Refseq : NP_005526
MIM : 601604
UniProt ID : P42701

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
04/06/2022

    Reliable in co-immunoprecipitation.

    10/18/2021

      Effective in asthma models.

      12/21/2017

        great in Western blot analysis.

        Q&As (10)

        Ask a question
        Could you explain the significance of CRISPR/Cas9-mediated gene tagging in tracking IL12RB1 localization? 09/18/2021

        Gene tagging allows real-time tracking of IL12RB1 subcellular localization.

        Can you elaborate on the use of RNA-seq analysis to profile gene expression changes upon IL12RB1 activation? 07/02/2021

        RNA-seq profiles gene expression changes upon IL12RB1 activation.

        What are the applications of ChIP-seq in exploring IL12RB1's role in gene regulation? 01/23/2021

        ChIP-seq investigates IL12RB1's impact on gene regulation networks.

        What methods can be employed to assess IL12RB1 dimerization and its effect on downstream signaling? 06/13/2020

        Crosslinking and immunoprecipitation assess IL12RB1 dimerization and signaling.

        What techniques are suitable for studying IL12RB1's interaction with IL12A and IL23A? 02/14/2020

        Co-immunoprecipitation and ELISA assay IL12RB1 interactions with cytokines.

        How can the role of IL12RB1 in signal transduction be elucidated using knockdown experiments? 12/27/2019

        Knockdown experiments reveal IL12RB1's contribution to signal transduction.

        What are the advantages of using siRNA screening to identify IL12RB1-regulated pathways? 02/22/2019

        siRNA screening identifies pathways influenced by IL12RB1 expression.

        How do co-crystallization studies aid in understanding the molecular details of IL12RB1 interactions? 01/02/2019

        Co-crystallization offers structural insights into IL12RB1 interactions.

        How does flow cytometry provide insights into IL12RB1 expression levels on different cell types? 10/26/2018

        Flow cytometry quantifies IL12RB1 levels on diverse cell populations.

        What experimental approaches validate IL12RB1's involvement in cytokine-mediated immune responses? 06/25/2018

        Functional assays validate IL12RB1's role in immune responses.

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