Active Recombinant Human IL17A Protein
Cat.No. : | IL17A-102H |
Product Overview : | Recombinant Human Interleukin-17A is produced by our E.coli expression system and the target gene encoding Ile20-Ala155 is expressed. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 um filtered solution of 20mM PB, pH 7.4. |
Bio-activity : | ED50 is approximately 2 ng/ml. Specific Activity of 5 x 10^5 IU/mg. Measured by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts. |
Protein Length : | Ile20-Ala155 |
AA Sequence : | MIVKAGITIPRNPGCPNSEDKNFPR TVMVNLNIHNRNTNTNPKRSSDYYN RSTSPWNLHRNEDPERY PSVIWEAKCRHLGCIN ADGNVDYHMNSVPIQQEILVLRREP PHCPNSFRLEKILVSVGCTCVTPIV HHVA |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug). |
Purity : | >95% |
Storage : | Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
Quality Statement : | Purity: Greater than 95% as determined by reducing SDS-PAGE. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Gene Name : | IL17A interleukin 17A [ Homo sapiens (human) ] |
Official Symbol : | IL17A |
Synonyms : | Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A |
Gene ID : | 3605 |
mRNA Refseq : | NM_002190.3 |
Protein Refseq : | NP_002181.1 |
MIM : | 603149 |
UniProt ID : | Q16552 |
Products Types
◆ Recombinant Protein | ||
IL17A-141R | Recombinant Rat IL17A Protein | +Inquiry |
IL17A-139M | Active Recombinant Mouse IL17A Protein | +Inquiry |
IL17A-48H | Recombinant Human IL17A Protein | +Inquiry |
IL17A-001C | Recombinant Cynomolgus Monkey IL17A Protein | +Inquiry |
IL17A-441R | Active Recombinant Rabbit IL17 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket