IL17A

  • Official Full Name

    interleukin 17A

  • Overview

    The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

  • Synonyms

    IL17A;interleukin 17A;IL17;CTLA8;IL-17;IL-17A;interleukin-17A;CTLA-8;cytotoxic T-lymphocyte-associated antigen 8;cytotoxic T-lymphocyte-associated protein 8;interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

Recombinant Proteins

  • Human
  • Mouse
  • Canine
  • Marmoset
  • Rat
  • Bovine
  • Equine
  • Rhesus macaque
  • Dog
  • Chicken
  • Rabbit
  • Ovine
  • Cynomolgus
  • Porcine
  • Pig
  • E.coli
  • Mouse
  • HEK293
  • CHO
  • Human
  • Yeast
  • Insect Cells
  • Mammalian Cells
  • Human Cells
  • Rat
  • GST
  • Non
  • Flag
  • His
  • Fc
  • Avi
  • T7
  • Alexa Fluor
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL17A-14153H Recombinant Human IL17A, GST-tagged E.coli Human GST 1-155a.a.
IL17A-26H Recombinant Human Interleukin-17 E.coli Human Non
Il17a-71M Recombinant Mouse Interleukin 17A E.coli Mouse Non
IL17A-035H-MAB Mouse Anti Human IL-17A Monoclonal Antibody, clone 1E4 (IVD grade) Mouse Human
IL17A-036H-MAB Mouse Anti Human IL-17A Monoclonal Antibody, clone 1G8 (IVD grade) Mouse Human
IL17A-112H Recombinant Human IL17A Protein, Flag tagged (IVD grade) Human Flag
IL17A-12C Active Recombinant Canine interleukin 17A protein, His tagged HEK293 Canine His 29-155 aa
Il17a-01M Active Recombinant Mouse Il17a Protein, His-Tagged E.coli Mouse His
IL17A&IL17F-165H Active Recombinant Human IL17A/IL17F Protein, Biotinylated CHO Human Non IL17A(Gly24-Ala155)/IL17F(Arg21-GLN163)
IL17A-001H Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged CHO Mouse Fc 1-142 a.a.
IL17A-113H Active Recombinant Human Interleukin 17A HEK293 Human Non
IL17A-166H Active Recombinant Human IL17A Protein, Biotinylated HEK293 Human Non Gly24-Ala155
IL17A-307H Active Recombinant Human IL17A protein CHO Human Non Met1-Ala155
IL17A-333H Active Recombinant Human IL17A Human Human Non
IL17A-425M Active Recombinant Marmoset IL17A protein E.coli Marmoset Non Ile20-Ala155
IL17A-487H Active Recombinant Human Interleukin 17A E.coli Human Non
IL17A-570H Active Recombinant Human Interleukin 17A, MIgG2a Fc-tagged CHO Human Fc 20-155 a.a.
IL17A-571H Active Recombinant Human Interleukin 17A, HIgG1 Fc-tagged, mutant CHO Human Fc 20-155 a.a.
IL17A-572H Active Recombinant Human Interleukin 17A, HIgG1 Fc-tagged CHO Human Fc 20-155 a.a.
IL17A-588M Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged, mutant CHO Mouse Fc 1-142 a.a.
Il17a-680R Active Recombinant Rat Il17a CHO Rat Non 26-158 a.a.
IL17A-1588C Active Recombinant Canine IL17A protein, His-tagged HEK293 Canine His 26-155 a.a.
Il17a-253I Active Recombinant Mouse Il17a Protein (133 aa) CHO Mouse 133
IL17A-491H Active Recombinant Human IL-17A Protein, His-tagged HEK293 Human His Gly24-Ala155
IL17A-5633H Recombinant Human IL17A protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Gly24-Ala155
Il17a-105M Active Recombinant Mouse Il17a protein E.coli Mouse Non Thr22-Ala158
IL17A-122H Recombinant Human IL17A protein E.coli Human Non 132
Il17a-12M Recombinant Mouse Il17a Yeast Mouse Non
IL17A-153M Recombinant Marmoset IL17A E.coli Marmoset Non 20-155 a.a.
IL17A-168C Active Recombinant Canine IL17A protein(Gly26-Ala155) E.coli Canine Non Gly26-Ala155
IL17A-236B Recombinant Bovine Interleukin 17A Yeast Bovine Non
IL17A-254E Recombinant Equine Interleukin 17A Yeast Equine Non
IL17A-261R Recombinant Rhesus IL17A protein(Met1-Ala155) Insect Cells Rhesus macaque Non Met1-Ala155
IL17A-279H Recombinant Human Interleukin 17A, Fc Chimera Mammalian Cells Human Fc
IL17A-28212TH Recombinant Human IL17A, Fc-tagged HEK293 Human Fc 155 amino acids
Il17a-334M Recombinant Mouse Il17a, His-tagged E.coli Mouse His 22-158 a.a.
IL17A-426H Recombinant Human Interleukin 17A, His-tagged Human Human His 24-155 a.a.
Il17a-489R Recombinant Rat Il17a protein E.coli Rat Non 133
Il17a-492R Active Recombinant Rat Interleukin-17AF Heterodimer E.coli Rat Non
IL17A-63H Recombinant Human IL17A, His-tagged Insect Cells Human His
IL17A-868D Recombinant Dog IL17A protein, His & T7-tagged E.coli Dog His&T7 Met1~Ala155
IL17A-869C Recombinant Chicken IL17A protein, His & GST-tagged E.coli Chicken GST&His Ile25~Ala169
IL17A-870H Recombinant Human IL17A protein, His & T7-tagged E.coli Human His&T7 Ile20~Ala155
Il17a-871R Recombinant Rat Il17a protein, His-tagged E.coli Rat His Ala18~Ser150
IL17A-872R Recombinant Rabbit IL17A protein, His-tagged E.coli Rabbit His Val21~Ala153
Il17a-89R Recombinant Rat Interleukin 17A E.coli Rat Non
IL17A-96C Recombinant Canine IL-17A Yeast Canine Non
IL17A-97H Recombinant Human IL-17A Yeast Human Non
IL17A-98O Recombinant Ovine IL-17A Yeast Ovine Non
IL17A-001HCL Recombinant Human IL17A cell lysate Human Cells Human Non
DMABT-H18989 Rat Anti-IL17A Monoclonal Antibody Rat Mouse Alexa Fluor
IL17A-001C Recombinant Cynomolgus Monkey IL17A Protein Yeast Cynomolgus Non
IL17a-0022H Recombinant Human IL17a Protein HEK293 Human
IL17A-002C Recombinant Cynomolgus IL17A protein (Met1-Ala155) Insect Cells Cynomolgus 1-155 a.a.
IL17A-01P GMP Recombinant Porcine IL17A Protein, His-Tagged E.coli Porcine His
IL17A-0246R Active Recombinant Rabbit IL17A protein E.coli Rabbit Non Gly24-Ala153
IL17A-0247C Recombinant Cynomolgus IL17A protein Insect Cells Cynomolgus Non Met1-Ala155
IL17A-055C Recombinant Cynomolgus IL17A(Gly24­Ala155) Protein, C-6*His-tagged HEK293 Cynomolgus His
IL17A-056C Recombinant Cynomolgus IL17A protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gly24-Ala155
Il17a-093M Active Recombinant Mouse Il17a Protein E.coli Mouse
Il17a-094M Active Recombinant Mouse Il17a Protein E.coli Mouse 26-158 a.a.
Il17a-095M Active Recombinant Mouse Il17a Protein E.coli Mouse 26-158;29-161 a.a.
Il17a-096M Recombinant Mouse Il17a Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
IL17A-1008P Recombinant Pig IL17A Protein, His-tagged E.coli Pig His Ile25-Ser153
IL17A-100I Active Recombinant Human IL17A Protein (136 aa) E.coli Human 136
IL17A-102H Active Recombinant Human IL17A Protein E.coli Human Ile20-Ala155
IL17A-1166H Recombinant Human IL17A Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IL17A-1166H-B Recombinant Human IL17A Protein Pre-coupled Magnetic Beads HEK293 Human
IL17A-116H Recombinant Human IL17A Protein, His-tagged Human Cells Human His 24-155 a.a.
IL17A-1235H Active Recombinant Human IL17A protein, His-tagged HEK293 Human His Ile20-Ala155
IL17A-137H Active Recombinant Human IL17A Protein E.coli Human
IL17A-138H Active Recombinant Human IL-17AF Heterodimer Protein E.coli Human
IL17A-139M Active Recombinant Mouse IL17A Protein E.coli Mouse
IL17A-140M Recombinant Mouse IL-17AF Heterodimer Protein E.coli Mouse
IL17A-141R Recombinant Rat IL17A Protein E.coli Rat
IL17A-142R Recombinant Rat IL-17AF Heterodimer Protein E.coli Rat
IL17A-148H Recombinant Active Human IL17A Protein, His-tagged(C-ter) E.coli Human His
Il17a-149M Recombinant Active Mouse IL17A Protein, His-tagged(C-ter) E.coli Mouse His
IL17A-1587H Active Recombinant Human IL17A protein HEK293 Human Non 24-155 a.a.
IL17A-15P Recombinant Pig IL17A Protein (Gly26-Ser155), C-His tagged, Animal-free, Carrier-free E.coli Pig His Gly26-Ser155
Il17a-180M Recombinant Mouse interleukin 17A Protein, Flag tagged HEK293 Mouse Flag 26-158aa
IL17A-1812H Recombinant Human IL17A protein(26-132aa), His-GST-tagged E.coli Human GST&His 26-132aa
IL17A-182H Active Recombinant Human IL17A Protein (Ile20-Ala155), C-His tagged, Animal-free, Carrier-free E.coli Human His Ile20-Ala155
IL17A-2293H Recombinant Human IL17A Protein, His-tagged E.coli Human His Ile20-Ala155
IL17A-254I Active Recombinant Human IL17A Protein (142 aa), His-tagged CHO Human His 142
IL17A-27H Active Recombinant Human IL17A Protein, Animal Free Human Cells Human
IL17A-3092R Recombinant Rhesus macaque IL17A protein, GST-tagged E.coli Rhesus macaque GST 24-155aa
IL17A-3093R Recombinant Rabbit IL17A protein, GST-tagged E.coli Rabbit GST 21-153aa
IL17A-3109H Recombinant Human IL17A Protein (Met1-Ala155), C-His tagged Mammalian Cells Human His Met1-Ala155
IL17A-3110H Recombinant Human IL17A Protein (Gly24-Ala155), N-His tagged E.coli Human His Gly24-Ala155
IL17A-381HB Recombinant Human IL17A protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly 24 - Ala 155.
IL17A-381M Active Recombinant Mouse IL17A Protein, His-tagged HEK293 Mouse His Ala 26 - Ala 158
IL17A-4311H Recombinant Human IL17A Protein (Gly24-Ala155), C-His tagged Mammalian Cells Human His Gly24-Ala155
IL17A-432P Recombinant Pig IL17A protein, His&Myc-tagged E.coli Pig His&Myc 24-153aa
IL17A-4331HG Active GMP Recombinant Human IL17A protein E.coli Human Non
IL17A-440R Active Recombinant Rabbit IL17 Protein, His-tagged Insect Cells Rabbit His Gly24-Ala153
IL17A-441R Active Recombinant Rabbit IL17 Protein, His-tagged E.coli Rabbit His Gly24-Ala153
IL17A-4688B Recombinant Bovine IL17A protein, His-tagged Yeast Bovine His
IL17A-48H Recombinant Human IL17A Protein E.coli Human Full L.
IL17A-508M Recombinant Mouse IL17A Protein Mouse 158
Il17a-52M Active Recombinant Mouse Il17a Protein (Ala26-Ala158), C-His tagged, Animal-free, Carrier-free E.coli Mouse His Ala26-Ala158
IL17A-5438R Recombinant Rabbit IL17A protein, His-tagged Yeast Rabbit His 21-153aa
IL17A-547H Recombinant Human IL17A protein, Biotinylated E.coli Human Non Ile20-Ala155
IL17A-57H Recombinant Human IL17A Protein, GST-tagged E.coli Human GST
IL17A-5856H Recombinant Human IL17A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IL17A-5H Human Interleukin-17 Reference standard Human Non
IL17A-674P Recombinant Pig IL17A protein, His-tagged E.coli Pig His 24-153a.a.
Il17a-678M Recombinant Mouse Il17a protein, His-Avi-tagged HEK293 Mouse Avi&His Ala26-Ala158
Il17a-678M-B Recombinant Mouse Il17a protein, His-Avi-tagged, Biotinylated HEK293 Mouse Avi&His Ala26-Ala158
IL17A-848M Recombinant Mouse IL17A Protein (Ala26-Ala158) Yeast Mouse Non Ala26-Ala158
IL17A-903HFL Recombinant Full Length Human IL17A Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    IL17A involved in several pathways and played different roles in them. We selected most pathways IL17A participated on our site, such as Cytokine-cytokine receptor interaction,Inflammatory bowel disease (IBD),Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rheumatoid arthritis ATP6V0D2,ATP6V1E2,ATP6V0E1,ATP6V1H,TGFB2,ATP6AP1,Il23a; Il12b,CXCL12,GM-CSF,CD80
    Cytokine-cytokine receptor interaction PDGFRB,RELT,CCR6,TNFSF8,CXCR3.1,IL1R1,IL-15RA,CXCL11,PDGFAA,CCL25
    Inflammatory bowel disease (IBD) HLA-DRB4,IL12RB2,IFNGR1,HLA-DMB,HLA-DRB5,TLR4,Il23a; Il12b,TLR5,HLA-DRA,STAT6

    Protein Function

    IL17A has several biochemical functions, for example, cytokine activity,cytokine receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17A itself. We selected most functions IL17A had, and list some proteins which have the same functions with IL17A. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity GDF11,KITLG,TNFSF15,CLCF1,CMTM7,INHBB,IFNA13,IL1RN,WNT7A,IFNG1-2
    cytokine receptor binding IL21,IL15L,IL17A/F2,IFNA13,IFNA3,IL17D,IFNPHI3,IFNA14,IFNA21,IFNA12
    protein binding FBXO18,SLC9A7,SMC6,PITPNC1,HADHA,PODXL2,CD2BP2,POLR1C,ACTR10,RWDD2B

    Interacting Protein

    IL17A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17A.

    DPH2

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    Neuroinflammation
    Cytokines and Growth Factors Secreted by VSMC
    gamma delta T Cells
    Natural Killer T (NKT) Cells
    T Cell Cytokine Signaling
    IL-17 Family Ligands
    Cytokines in Tumorigenesis

    References

    • Mease, PJ; et al. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. CURRENT OPINION IN RHEUMATOLOGY 27:127-133(2015).
    • Ji, PY; Hu, HL; et al. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. PARASITOLOGY RESEARCH 114:613-624(2015).

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