IL17A Protein


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Official Full Name interleukin 17A
Background The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Synonyms IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8);
    • Species :
    • Bovine
    • Canine
    • Chicken
    • Cynomolgus
    • Cynomolgus monkey
    • Dog
    • Equine
    • Human
    • Marmoset
    • Mouse
    • Ovine
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Source :
    • Baculovirus-Insect Cells
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Rat
    • Yeast
    • Tag :
    • Alexa Fluor 488
    • Fc
    • GST
    • His
    • His(C-ter)
    • T7
    • His-Avi
    • Myc/DDK
    • N/A
    • N-His
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL17A&IL17F-165H Recombinant Human IL17A/IL17F Protein, Biotinylated CHO N/A
    Human IL17A-113H Recombinant Human Interleukin 17A HEK293 N/A
    Human IL17A-166H Recombinant Human IL17A Protein, Biotinylated HEK293 N/A
    Human IL17A-307H Recombinant Human IL17A CHO N/A
    Human IL17A-333H Recombinant Human IL17A Human N/A
    Human IL17A-487H Recombinant Human Interleukin 17A E.coli N/A
    Human IL17A-570H Recombinant Human Interleukin 17A, MIgG2a Fc-tagged CHO Fc
    Human IL17A-571H Recombinant Human Interleukin 17A, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL17A-572H Recombinant Human Interleukin 17A, HIgG1 Fc-tagged CHO Fc
    Mouse IL17A-001H Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged CHO Fc
    Mouse IL17A-588M Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged, mutant CHO Fc
    Rat Il17a-492R Recombinant Rat Interleukin-17AF Heterodimer E.coli N/A
    Rat Il17a-680R Recombinant Rat Il17a CHO N/A
    Bovine IL17A-236B Recombinant Bovine Interleukin 17A Yeast N/A
    Equine IL17A-254E Recombinant Equine Interleukin 17A Yeast N/A
    Marmoset IL17A-425M Recombinant Marmoset IL17A E.coli N/A
    Human IL17A-491H Recombinant Human IL-17A Protein, His-tagged HEK293 His
    Mouse Il17a-01M Recombinant Mouse Il17a Protein, His-Tagged E.coli His
    Rhesus Macaque IL17A&IL17F-262R Recombinant Rhesus IL17A/IL17F protein, His-tagged HEK293 His
    Rhesus Macaque IL17A-261R Recombinant Rhesus IL17A protein Insect Cell N/A
    Human IL17A-122H Recombinant Human IL17A protein E.coli N/A
    Human IL17A-14153H Recombinant Human IL17A, GST-tagged E.coli GST
    Human IL17A-26H Recombinant Human Interleukin-17 E.coli N/A
    Human IL17A-279H Recombinant Human Interleukin 17A, Fc Chimera Mammalian Cell Fc
    Human IL17A-28212TH Recombinant Human IL17A, Fc-tagged HEK293 Fc
    Human IL17A-288H Recombinant Human IL17A, StrepII-tagged Human Cell Strep II
    Human IL17A-426H Recombinant Human Interleukin 17A, His-tagged Human His
    Human IL17A-445H Recombinant Human IL17A Protein, His-tagged Yeast His
    Human IL17A-63H Recombinant Human IL17A, His-tagged Insect Cell His
    Human IL17A-7334H Recombinant Human IL17A, His tagged Insect Cell His
    Human IL17A-7335H Recombinant Human IL17A, None tagged E.coli N/A
    Human IL17A-870H Recombinant Human IL17A protein, His & T7-tagged E.coli His/T7
    Human IL17A-97H Recombinant Human IL-17A Yeast N/A
    Mouse Il17a-105M Recombinant Mouse Il17a, None tagged E.coli N/A
    Mouse Il17a-12M Recombinant Mouse Il17a Yeast N/A
    Mouse Il17a-334M Recombinant Mouse Il17a, His-tagged E.coli His
    Mouse Il17a-71M Recombinant Mouse Interleukin 17A E.coli N/A
    Rat Il17a-489R Recombinant Rat Il17a protein E.coli N/A
    Rat Il17a-871R Recombinant Rat Il17a protein, His-tagged E.coli His
    Rat Il17a-89R Recombinant Rat Interleukin 17A E.coli N/A
    Canine IL17A-168C Recombinant Canine IL17A E.coli N/A
    Dog IL17A-868D Recombinant Dog IL17A protein, His & T7-tagged E.coli His/T7
    Canine IL17A-96C Recombinant Canine IL-17A Yeast N/A
    Chicken IL17A-869C Recombinant Chicken IL17A protein, His & GST-tagged E.coli His/GST
    Rabbit IL17A-872R Recombinant Rabbit IL17A protein, His-tagged E.coli His
    Marmoset IL17A-153M Recombinant Marmoset IL17A E.coli N/A
    Ovine IL17A-98O Recombinant Ovine IL-17A Yeast N/A
    Human IL17A-001HCL Recombinant Human IL17A cell lysate Human Cell N/A
    Mouse Il17a-678M-B Recombinant Mouse Il17a protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Porcine IL17A-01P GMP Recombinant Porcine IL17A Protein, His-Tagged E.coli His
    Cynomolgus IL17A-055C Recombinant Cynomolgus IL17A(Gly24­Ala155) Protein, C-6*His-tagged HEK293 His
    Pig IL17A-1008P Recombinant Pig IL17A Protein, His-tagged E.coli N-His
    Canine IL17A-12C Recombinant Canine IL17A Protein, His-tagged HEK293 His
    Human IL17A-148H Recombinant Active Human IL17A Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il17a-149M Recombinant Active Mouse IL17A Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL17A-2293H Recombinant Human IL17A Protein, His-tagged E.coli N-His
    Rhesus macaque IL17A-3092R Recombinant Rhesus macaque IL17A protein, GST-tagged E.coli GST
    Rabbit IL17A-3093R Recombinant Rabbit IL17A protein, GST-tagged E.coli GST
    Human IL17A-48H Recombinant Human IL17A Protein E.coli
    Rabbit IL17A-5438R Recombinant Rabbit IL17A protein, His-tagged Yeast His
    Human IL17A-57H Recombinant Human IL17A Protein, GST-tagged E.coli GST
    Human IL17A & IL17F-01H Recombinant Human IL17A & IL17F protein, His-Avi-tagged HEK293 His-Avi
    Human IL17A-381HB Recombinant Human IL17A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL17A-4331HG GMP Recombinant Human IL17A protein E.coli N/A
    Human IL17A-547H Recombinant Human IL17A Protein (Ile20-Ala155), Met, Biotinylated E.coli N/A
    Human IL17A-5856H Recombinant Human IL17A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL17A-5H Human Interleukin-17 Reference standard N/A
    Mouse DMABT-H18989 Rat Anti-IL17A Monoclonal Antibody Rat Alexa Fluor 488
    Mouse Il17a-093M Recombinant Mouse Il17a Protein E.coli
    Mouse Il17a-094M Recombinant Mouse Il17a Protein E.coli
    Mouse Il17a-095M Recombinant Mouse Il17a Protein E.coli
    Mouse Il17a-096M Recombinant Mouse Il17a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse IL17A-381M Recombinant Mouse IL17A Protein, His-tagged HEK293 His
    Mouse Il17a-678M Recombinant Mouse Il17a protein, His-Avi-tagged HEK293 His-Avi
    Mouse IL17A-848M Recombinant Mouse IL17A Protein (Ala26-Ala158) Yeast N/A
    Cynomolgus monkey IL17A-001C Recombinant Cynomolgus Monkey IL17A Protein Yeast N/A
    Cynomolgus IL17A-002C Recombinant Cynomolgus IL17A protein (Met1-Ala155) Baculovirus-Insect Cells
    Cynomolgus IL17A-056C Recombinant Cynomolgus IL17A protein, His-Avi-tagged HEK293 His-Avi
    Rabbit IL17A-440R Recombinant Rabbit IL17 Protein, His-tagged Insect Cell His
    Rabbit IL17A-441R Recombinant Rabbit IL17 Protein, His-tagged E.coli His

    IL17A involved in several pathways and played different roles in them. We selected most pathways IL17A participated on our site, such as Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFSF15; FLT3LG; IFNA13; INHBA; BMPR2B; IFNA1; CCL25B; IL-15RA; TGFBR1B; CCR9A
    Inflammatory bowel disease (IBD) IL1B; IL23; HLA-DMA; SMAD2; IFNG; TBX21; MAF; IL12RB2; HLA-DMB; GATA3
    Rheumatoid arthritis HLA-DRA; HLA-DPA1; CXCL1; ATP6V0E2; ATP6AP1; TNFSF13; TNFRSF11A; TLR4; ANGPT1; CXCL6

    IL17A has several biochemical functions, for example, cytokine activity, cytokine receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17A itself. We selected most functions IL17A had, and list some proteins which have the same functions with IL17A. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity INHBE; GDF10B; THPO; IFNA5; GDF10; CMTM7; CCL38A.5; LEFTY1; WNT7A; TGFB1A
    cytokine receptor binding IFNA21; IL15L; IFNT2; IFNA14; IFNA13; IFNA3; IFNA5; IL17F; IFNPHI4; IL15
    protein binding XRCC2; ZNF41; MLH3; FCRL2; NAA38; MAD2L1BP; SERPINA1; JIP1; STRADB; LARP2

    IL17A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17A.


    Mease, PJ; et al. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. CURRENT OPINION IN RHEUMATOLOGY 27:127-133(2015).
    Ji, PY; Hu, HL; et al. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. PARASITOLOGY RESEARCH 114:613-624(2015).


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