IL17A
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Official Full Name
interleukin 17A
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Background
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] -
Synonyms
IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8);
- Involved Pathway
- Protein Function
- Interacting Protein
- IL17A Related Articles
- IL17A Related Gene Family
- IL17A Related Research Area
IL17A involved in several pathways and played different roles in them. We selected most pathways IL17A participated on our site, such as Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR3;TNFRSF14;CCL28;LIFRA;TGFBR2;IFNB1;CXCL8;LEPB;CXCR4A |
| Inflammatory bowel disease (IBD) | IL12A;STAT1;HLA-DMA;H2-AB1;IL22;HLA-DQA1;TBX21;IL23;IL1A |
| Rheumatoid arthritis | HLA-DRA;ATP6V0A1;H2-AB1;TEK;ATP6V0E1;HLA-DRB3;IL1B;CXCL6;HLA-DMB |
IL17A has several biochemical functions, for example, cytokine activity, cytokine receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17A itself. We selected most functions IL17A had, and list some proteins which have the same functions with IL17A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CSF3;INHBE;INHBA;IFNL3;SLURP1;BMP2B;NRG1;GPI1;IL1F10 |
| cytokine receptor binding | IFNA21;MIF;IFNA12;IL17A/F2;IFN-a;IL17B;IL17D;IL17C;IFNA14 |
| protein binding | SIX3;CHD;ARFGAP1;TAF12;GNB2;LMX1B;MED6;MRM1;FAP |
IL17A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17A.
DPH2
- Q&As
- Reviews
Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
Customer Reviews (3)
Write a reviewGood for receptor studies. -
Effective in Th17 differentiation. -
High bioactivity in various tissue types. -
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