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The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
IL17A involved in several pathways and played different roles in them. We selected most pathways IL17A participated on our site, such as Cytokine-cytokine receptor interaction,Inflammatory bowel disease (IBD),Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
IL17A has several biochemical functions, for example, cytokine activity,cytokine receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17A itself. We selected most functions IL17A had, and list some proteins which have the same functions with IL17A. You can find most of the proteins on our site.
IL17A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17A.
Mease, PJ; et al. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. CURRENT OPINION IN RHEUMATOLOGY 27:127-133(2015).
Ji, PY; Hu, HL; et al. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. PARASITOLOGY RESEARCH 114:613-624(2015).
