IL17A

  • Official Full Name

    interleukin 17A

  • Overview

    The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
  • Synonyms

    IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Bovine
  • Canine
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Dog
  • Equine
  • Human
  • Marmoset
  • Mouse
  • Ovine
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus macaque
  • Baculovirus-Insect Cells
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Rat
  • Yeast
  • Alexa Fluor 488
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|GST
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL17A-571H Active Recombinant Human Interleukin 17A, HIgG1 Fc-tagged, mutant CHO Fc
Human IL17A-113H Active Recombinant Human Interleukin 17A HEK293 N/A
Human IL17A-307H Active Recombinant Human IL17A protein CHO N/A Met1-Ala155
Human IL17A-572H Active Recombinant Human Interleukin 17A, HIgG1 Fc-tagged CHO Fc
Human IL17A-570H Active Recombinant Human Interleukin 17A, MIgG2a Fc-tagged CHO Fc
Human IL17A-487H Active Recombinant Human Interleukin 17A E.coli N/A
Human IL17A&IL17F-165H Active Recombinant Human IL17A/IL17F Protein, Biotinylated CHO N/A IL17A(Gly24-Ala155)/IL17F(Arg21-GLN163)
Human IL17A-166H Active Recombinant Human IL17A Protein, Biotinylated HEK293 N/A Gly24-Ala155
Human IL17A-333H Active Recombinant Human IL17A Human N/A
Human IL17A-491H Active Recombinant Human IL-17A Protein, His-tagged HEK293 His Gly24-Ala155
Human IL17A-122H Recombinant Human IL17A protein E.coli N/A 132
Human IL17A-26H Recombinant Human Interleukin-17 E.coli N/A
Human IL17A-63H Recombinant Human IL17A, His-tagged Insect Cell His
Human IL17A-870H Recombinant Human IL17A protein, His & T7-tagged E.coli His/T7 Ile20~Ala155 (Accession # Q16552)
Human IL17A-97H Recombinant Human IL-17A Yeast N/A
Human IL17A-426H Recombinant Human Interleukin 17A, His-tagged Human His
Human IL17A-288H Recombinant Human IL17A, StrepII-tagged Human Cell Strep II 24-155, 132 a.a.
Human IL17A-279H Recombinant Human Interleukin 17A, Fc Chimera Mammalian Cell Fc
Human IL17A-28212TH Recombinant Human IL17A, Fc-tagged HEK293 Fc 155 amino acids
Human IL17A-14153H Recombinant Human IL17A, GST-tagged E.coli GST 1-155a.a.
Human IL17A-445H Recombinant Human IL17 protein(Gly24-Ala155), His-tagged Yeast N-His Gly24-Ala155
Human IL17A-001HCL Recombinant Human IL17A cell lysate Human Cell N/A
Human IL17A-138H Active Recombinant Human IL-17AF Heterodimer Protein E.coli
Human IL17A & IL17F-01H Recombinant Human IL17A & IL17F protein, His-Avi-tagged HEK293 His-Avi It contains Gly 24 - Ala 155 (IL-17A) & Arg31-Gln163.
Human IL17A-4331HG Active GMP Recombinant Human IL17A protein E.coli N/A
Human IL17A-5H Human Interleukin-17 Reference standard N/A
Human IL17A-116H Recombinant Human IL17A Protein, His-tagged Human Cell His
Human IL17A-2293H Recombinant Human IL17A Protein, His-tagged E.coli N-His Ile20-Ala155
Human IL17A-381HB Recombinant Human IL17A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Gly 24 - Ala 155.
Human IL17A-57H Recombinant Human IL17A Protein, GST-tagged E.coli GST
Human IL17a-0022H Recombinant Human IL17a Protein HEK293 cells
Human IL17A-148H Recombinant Active Human IL17A Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL17A-5856H Recombinant Human IL17A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL17A-1587H Active Recombinant Human IL17A protein HEK293 N/A Gly24-Ala155
Human IL17A-100I Active Recombinant Human IL17A Protein (136 aa) E.coli 136
Human IL17A-137H Active Recombinant Human IL17A Protein E.coli
Human IL17A-903HFL Recombinant Full Length Human IL17A Protein, C-Flag-tagged Mammalian cells Flag
Human IL17A-27H Active Recombinant Human IL17A Protein, Animal Free Human cells
Human IL17A-1235H Active Recombinant Human IL17A protein, His-tagged HEK293 His Ile20-Ala155
Human IL17A-102H Active Recombinant Human IL17A Protein E.coli Ile20-Ala155
Human IL17A-254I Active Recombinant Human IL17A Protein (142 aa), His-tagged CHO His 142
Human IL17A-3109H Recombinant Human IL17A Protein (Met1-Ala155), C-His tagged Mammalian cells C-His Met1-Ala155
Human IL17A-1166H-B Recombinant Human IL17A Protein Pre-coupled Magnetic Beads HEK293
Human IL17A-1166H Recombinant Human IL17A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL17A-3110H Recombinant Human IL17A Protein (Gly24-Ala155), N-His tagged E.coli N-His Gly24-Ala155
Human IL17A-4311H Recombinant Human IL17A Protein (Gly24-Ala155), C-His tagged Mammalian cells C-His Gly24-Ala155
Human IL17A-547H Recombinant Human IL17A protein, Biotinylated E.coli N/A Ile20-Ala155
Human IL17A-182H Active Recombinant Human IL17A Protein (Ile20-Ala155), C-His tagged, Animal-free, Carrier-free E.coli C-His Ile20-Ala155
Human IL17A-48H Recombinant Human IL17A Protein E.coli
Human IL17A-1812H Recombinant Human IL17A protein(26-132aa), His-GST-tagged E.coli N-His-GST 26-132aa
Mouse Il17a-01M Active Recombinant Mouse Il17a Protein, His-Tagged E.coli His
Mouse IL17A-001H Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged CHO Fc
Mouse IL17A-588M Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged, mutant CHO Fc
Mouse Il17a-253I Active Recombinant Mouse Il17a Protein (133 aa) CHO 133
Mouse Il17a-105M Active Recombinant Mouse Il17a protein E.coli N/A Thr22-Ala158
Mouse Il17a-334M Recombinant Mouse Il17a, His-tagged E.coli His
Mouse Il17a-12M Recombinant Mouse Il17a Yeast N/A
Mouse Il17a-71M Recombinant Mouse Interleukin 17A E.coli N/A
Mouse IL17A-139M Active Recombinant Mouse IL17A Protein E.coli
Mouse Il17a-678M-B Recombinant Mouse Il17a protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala26-Ala158
Mouse IL17A-848M Recombinant Mouse IL17A Protein (Ala26-Ala158) Yeast N/A Ala26-Ala158
Mouse Il17a-149M Recombinant Active Mouse IL17A Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il17a-094M Active Recombinant Mouse Il17a Protein E.coli
Mouse IL17A-381M Active Recombinant Mouse IL17A Protein, His-tagged HEK293 His Ala 26 - Ala 158
Mouse Il17a-093M Active Recombinant Mouse Il17a Protein E.coli
Mouse Il17a-52M Active Recombinant Mouse Il17a Protein (Ala26-Ala158), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala26-Ala158
Mouse Il17a-096M Recombinant Mouse Il17a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Il17a-095M Active Recombinant Mouse Il17a Protein E.coli
Mouse Il17a-678M Recombinant Mouse Il17a protein, His-Avi-tagged HEK293 His-Avi It contains Ala26-Ala158.
Mouse DMABT-H18989 Rat Anti-IL17A Monoclonal Antibody Rat Alexa Fluor 488
Mouse IL17A-508M Recombinant Mouse IL17A Protein 158
Mouse IL17A-140M Recombinant Mouse IL-17AF Heterodimer Protein E.coli
Rat Il17a-680R Active Recombinant Rat Il17a CHO N/A
Rat Il17a-489R Recombinant Rat Il17a protein E.coli N/A 133
Rat Il17a-492R Active Recombinant Rat Interleukin-17AF Heterodimer E.coli N/A
Rat Il17a-89R Recombinant Rat Interleukin 17A E.coli N/A
Rat Il17a-871R Recombinant Rat Il17a protein, His-tagged E.coli His Ala18~Ser150
Rat IL17A-141R Recombinant Rat IL17A Protein E.coli
Rat IL17A-142R Recombinant Rat IL-17AF Heterodimer Protein E.coli
Rabbit IL17A-872R Recombinant Rabbit IL17A protein, His-tagged E.coli His Val21~Ala153
Rabbit IL17A-5438R Recombinant Rabbit IL17A protein, His-tagged Yeast His 21-153aa
Rabbit IL17A-3093R Recombinant Rabbit IL17A protein, GST-tagged E.coli GST 21-153aa
Rabbit IL17A-0246R Active Recombinant Rabbit IL17A protein E.coli N/A Gly24-Ala153
Rabbit IL17A-440R Active Recombinant Rabbit IL17 Protein, His-tagged Insect Cell His Gly24-Ala153
Rabbit IL17A-441R Active Recombinant Rabbit IL17 Protein, His-tagged E.coli His Gly24-Ala153
Dog IL17A-868D Recombinant Dog IL17A protein, His & T7-tagged E.coli His/T7 Met1~Ala155 (Accession # C6L8D7)
Bovine IL17A-236B Recombinant Bovine Interleukin 17A Yeast N/A
Canine IL17A-1588C Active Recombinant Canine IL17A protein, His-tagged HEK293 His Gly26-Ala155
Canine IL17A-168C Active Recombinant Canine IL17A protein(Gly26-Ala155) E.coli N/A Gly26-Ala155
Canine IL17A-96C Recombinant Canine IL-17A Yeast N/A
Canine IL17A-12C Active Recombinant Canine IL17A Protein, His-tagged HEK293 His 29-115
Cynomolgus IL17A-055C Recombinant Cynomolgus IL17A(Gly24­Ala155) Protein, C-6*His-tagged HEK293 His
Cynomolgus IL17A-056C Recombinant Cynomolgus IL17A protein, His-Avi-tagged HEK293 His-Avi It contains Gly24-Ala155.
Cynomolgus IL17A-0247C Recombinant Cynomolgus IL17A protein Insect Cells N/A Met1-Ala155
Cynomolgus IL17A-002C Recombinant Cynomolgus IL17A protein (Met1-Ala155) Baculovirus-Insect Cells
Cynomolgus monkey IL17A-001C Recombinant Cynomolgus Monkey IL17A Protein Yeast N/A
Equine IL17A-254E Recombinant Equine Interleukin 17A Yeast N/A
Marmoset IL17A-425M Active Recombinant Marmoset IL17A protein E.coli N/A Ile20-Ala155
Marmoset IL17A-153M Recombinant Marmoset IL17A E.coli N/A
Ovine IL17A-98O Recombinant Ovine IL-17A Yeast N/A
Porcine IL17A-01P GMP Recombinant Porcine IL17A Protein, His-Tagged E.coli His
Rhesus IL17A-261R Recombinant Rhesus IL17A protein(Met1-Ala155) Insect Cells N/A Met1-Ala155
Rhesus macaque IL17A-3092R Recombinant Rhesus macaque IL17A protein, GST-tagged E.coli GST 24-155aa
Pig IL17A-15P Recombinant Pig IL17A Protein (Gly26-Ser155), C-His tagged, Animal-free, Carrier-free E.coli C-His Gly26-Ser155
Pig IL17A-1008P Recombinant Pig IL17A Protein, His-tagged E.coli N-His Ile25-Ser153
Chicken IL17A-869C Recombinant Chicken IL17A protein, His & GST-tagged E.coli His/GST Ile25~Ala169
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL17A involved in several pathways and played different roles in them. We selected most pathways IL17A participated on our site, such as Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL15;IL6R;VEGFAB;PDGFRB;IL12BA;Ccl21a;CCR3;IFNB;FASLG
Inflammatory bowel disease (IBD)TGFB2;SMAD2;HLA-DOB;HLA-DMA;RORC;H2-AA;FOXP3;HLA-DQA2;Il23a; Il12b
Rheumatoid arthritisIL11;CXCL6;ATP6V1D;LTB;ATP6V1A;HLA-DRA;IL23;ATP6V0A4;ATP6V0D2

IL17A has several biochemical functions, for example, cytokine activity, cytokine receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17A itself. We selected most functions IL17A had, and list some proteins which have the same functions with IL17A. You can find most of the proteins on our site.

Function Related Protein
cytokine activityGM13278;IL5;IL21;IL33;IFNA16;IFNA13;GDF6B;TNFSF18;IL4
cytokine receptor bindingMIF;IL15L;IL21;IFNT2;IFNA12;IFNA8;IL17A/F1;Ifna11;IFNA21
protein bindingTHAP3;RTDR1;MAP3K11;CDK9;AUP1;CALML3;CACNA2D1A;ATRIP;PSMC3

IL17A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17A.

DPH2

Gene Family

IL

Research Area

Related articles

Mease, PJ; et al. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. CURRENT OPINION IN RHEUMATOLOGY 27:127-133(2015).
Ji, PY; Hu, HL; et al. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. PARASITOLOGY RESEARCH 114:613-624(2015).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
Could you explain the role of IL17A in autoimmune disease progression using animal models? 05/22/2022

Animal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.

Can you detail the protocols for inducing IL17A expression in T cells in vitro? 01/02/2021

Inducing IL17A expression in T cells involves culturing them with specific cytokines.

What strategies elucidate IL17A's impact on tissue-specific inflammation in human samples? 02/17/2020

Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.

Can you elaborate on the use of neutralizing antibodies in blocking IL17A's effects? 06/12/2019

Neutralizing antibodies block IL17A's effects in cell cultures or animal models.

How does one perform a multiplex cytokine assay to quantify IL17A along with other cytokines? 12/13/2018

Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.

How is the IL17A receptor (IL17RA) signaling pathway activated and studied? 11/23/2018

IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.

What are the methods to investigate the impact of IL17A on epithelial barrier integrity? 08/09/2018

Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.

How is IL17A's contribution to neutrophil recruitment assessed in inflammatory models? 06/25/2018

Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.

What techniques are used to analyze IL17A-producing cell populations within a tissue? 06/22/2018

Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.

What experimental design is employed to understand IL17A's involvement in cancer development? 03/23/2018

Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.

Customer Reviews (3)

Write a review
Reviews
12/16/2018

    Good for receptor studies.

    03/05/2018

      Effective in Th17 differentiation.

      03/08/2017

        High bioactivity in various tissue types.

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