• Official Full Name

    interleukin 17A

  • Background

    The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
  • Synonyms

    IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8);
    • Type:
    • Recombinant Proteins
    • Transfected Stable Cell Lines
    • Cell & Tissue Lysates
    • GMP Proteins
    • Protein Pre-coupled Magnetic Beads
    • Antibody
    • Species :
    • Bovine
    • Canine
    • Chicken
    • Cynomolgus
    • Cynomolgus monkey
    • Dog
    • Equine
    • Human
    • Marmoset
    • Mouse
    • Ovine
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus macaque
    • Rhesus Macaque
    • Source :
    • Baculovirus-Insect Cells
    • CHO
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Human
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Rat
    • Yeast
    • Tag :
    • Alexa Fluor 488
    • Fc
    • Flag
    • GST
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|GST
    • His|T7
    • Myc
    • DDK
    • MYC
    • N/A
    • N
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine IL17A-236B Recombinant Bovine Interleukin 17A Yeast N/A
    Canine IL17A-168C Recombinant Canine IL17A E.coli N/A
    Canine IL17A-96C Recombinant Canine IL-17A Yeast N/A
    Canine IL17A-1588C Recombinant Canine IL17A protein, His-tagged HEK293 His
    Canine IL17A-12C Recombinant Canine IL17A Protein, His-tagged HEK293 His
    Chicken IL17A-869C Recombinant Chicken IL17A protein, His & GST-tagged E.coli His/GST
    Cynomolgus IL17A-056C Recombinant Cynomolgus IL17A protein, His-Avi-tagged HEK293 His-Avi
    Cynomolgus IL17A-055C Recombinant Cynomolgus IL17A(Gly24­Ala155) Protein, C-6*His-tagged HEK293 His
    Cynomolgus IL17A-002C Recombinant Cynomolgus IL17A protein (Met1-Ala155) Baculovirus-Insect Cells
    Cynomolgus monkey IL17A-001C Recombinant Cynomolgus Monkey IL17A Protein Yeast N/A
    Dog IL17A-868D Recombinant Dog IL17A protein, His & T7-tagged E.coli His/T7
    Equine IL17A-254E Recombinant Equine Interleukin 17A Yeast N/A
    Human IL17A & IL17F-01H Recombinant Human IL17A & IL17F protein, His-Avi-tagged HEK293 His-Avi
    Human IL17A-166H Active Recombinant Human IL17A Protein, Biotinylated HEK293 N/A
    Human IL17A-5H Human Interleukin-17 Reference standard N/A
    Human IL17A-333H Active Recombinant Human IL17A Human N/A
    Human IL17A-491H Active Recombinant Human IL-17A Protein, His-tagged HEK293 His
    Human IL17A-547H Recombinant Human IL17A protein, Biotinylated E.coli N/A
    Human IL17A-445H Recombinant Human IL17A Protein, His-tagged Yeast His
    Human IL17A-63H Recombinant Human IL17A, His-tagged Insect Cell His
    Human IL17A-2293H Recombinant Human IL17A Protein, His-tagged E.coli N-His
    Human IL17A-48H Recombinant Human IL17A Protein E.coli
    Human IL17A-001HCL Recombinant Human IL17A cell lysate Human Cell N/A
    Human IL17A-7335H Recombinant Human IL17A, None tagged E.coli N/A
    Human IL17A-148H Recombinant Active Human IL17A Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL17A-122H Recombinant Human IL17A protein E.coli N/A
    Human IL17A-28212TH Recombinant Human IL17A, Fc-tagged HEK293 Fc
    Human IL17A-288H Recombinant Human IL17A, StrepII-tagged Human Cell Strep II
    Human IL17A-137H Recombinant Human IL17A Protein E.coli
    Human IL17A-97H Recombinant Human IL-17A Yeast N/A
    Human IL17A-14153H Recombinant Human IL17A, GST-tagged E.coli GST
    Human IL17A-113H Active Recombinant Human Interleukin 17A HEK293 N/A
    Human IL17A-307H Recombinant Human IL17A protein CHO N/A
    Human IL17A-572H Active Recombinant Human Interleukin 17A, HIgG1 Fc-tagged CHO Fc
    Human IL17A-7334H Recombinant Human IL17A, His tagged Insect Cell His
    Human IL17A-487H Active Recombinant Human Interleukin 17A E.coli N/A
    Human IL17A-279H Recombinant Human Interleukin 17A, Fc Chimera Mammalian Cell Fc
    Human IL17A-138H Recombinant Human IL-17AF Heterodimer Protein E.coli
    Human IL17A-571H Active Recombinant Human Interleukin 17A, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL17A-903HFL Recombinant Full Length Human IL17A Protein, C-Flag-tagged Mammalian cells Flag
    Human IL17A-870H Recombinant Human IL17A protein, His & T7-tagged E.coli His/T7
    Human IL17A-116H Recombinant Human IL17A Protein, His-tagged Human Cell His
    Human IL17A-426H Recombinant Human Interleukin 17A, His-tagged Human His
    Human IL17A-4331HG GMP Recombinant Human IL17A protein E.coli N/A
    Human IL17A&IL17F-165H Active Recombinant Human IL17A/IL17F Protein, Biotinylated CHO N/A
    Human IL17a-0022H Recombinant Human IL17a Protein HEK293 cells
    Human IL17A-570H Active Recombinant Human Interleukin 17A, MIgG2a Fc-tagged CHO Fc
    Human IL17A-381HB Recombinant Human IL17A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL17A-27H Recombinant Human IL17A Protein, Animal Free Human cells
    Human IL17A-100I Recombinant Human IL17A Protein (136 aa) E.coli
    Human IL17A-26H Recombinant Human Interleukin-17 E.coli N/A
    Human IL17A-5856H Recombinant Human IL17A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL17A-102H Recombinant Human IL17A Protein E.coli
    Human IL17A-1235H Recombinant Human IL17A protein, His-tagged HEK293 His
    Human IL17A-57H Recombinant Human IL17A Protein, GST-tagged E.coli GST
    Human IL17A-254I Recombinant Human IL17A Protein (142 aa), His-tagged CHO His
    Human IL17A-1587H Recombinant Human IL17A protein HEK293 N/A
    Human IL17A-1166H-B Recombinant Human IL17A Protein Pre-coupled Magnetic Beads HEK293
    Human IL17A-1166H Recombinant Human IL17A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Marmoset IL17A-153M Recombinant Marmoset IL17A E.coli N/A
    Marmoset IL17A-425M Recombinant Marmoset IL17A protein E.coli N/A
    Mouse Il17a-149M Recombinant Active Mouse IL17A Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il17a-105M Recombinant Mouse Il17a protein E.coli N/A
    Mouse Il17a-01M Active Recombinant Mouse Il17a Protein, His-Tagged E.coli His
    Mouse DMABT-H18989 Rat Anti-IL17A Monoclonal Antibody Rat Alexa Fluor 488
    Mouse Il17a-334M Recombinant Mouse Il17a, His-tagged E.coli His
    Mouse IL17A-139M Recombinant Mouse IL17A Protein E.coli
    Mouse Il17a-678M-B Recombinant Mouse Il17a protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Mouse IL17A-848M Recombinant Mouse IL17A Protein (Ala26-Ala158) Yeast N/A
    Mouse Il17a-71M Recombinant Mouse Interleukin 17A E.coli N/A
    Mouse Il17a-094M Recombinant Mouse Il17a Protein E.coli
    Mouse IL17A-381M Recombinant Mouse IL17A Protein, His-tagged HEK293 His
    Mouse Il17a-093M Recombinant Mouse Il17a Protein E.coli
    Mouse Il17a-095M Recombinant Mouse Il17a Protein E.coli
    Mouse Il17a-096M Recombinant Mouse Il17a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il17a-253I Recombinant Mouse Il17a Protein (133 aa) CHO
    Mouse Il17a-678M Recombinant Mouse Il17a protein, His-Avi-tagged HEK293 His-Avi
    Mouse Il17a-12M Recombinant Mouse Il17a Yeast N/A
    Mouse IL17A-001H Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged CHO Fc
    Mouse IL17A-588M Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse IL17A-140M Recombinant Mouse IL-17AF Heterodimer Protein E.coli
    Mouse IL17A-508M Recombinant Mouse IL17A Protein
    Ovine IL17A-98O Recombinant Ovine IL-17A Yeast N/A
    Pig IL17A-1008P Recombinant Pig IL17A Protein, His-tagged E.coli N-His
    Porcine IL17A-01P GMP Recombinant Porcine IL17A Protein, His-Tagged E.coli His
    Rabbit IL17A-3093R Recombinant Rabbit IL17A protein, GST-tagged E.coli GST
    Rabbit IL17A-5438R Recombinant Rabbit IL17A protein, His-tagged Yeast His
    Rabbit IL17A-440R Recombinant Rabbit IL17 Protein, His-tagged Insect Cell His
    Rabbit IL17A-441R Recombinant Rabbit IL17 Protein, His-tagged E.coli His
    Rabbit IL17A-872R Recombinant Rabbit IL17A protein, His-tagged E.coli His
    Rat Il17a-680R Active Recombinant Rat Il17a CHO N/A
    Rat IL17A-141R Recombinant Rat IL17A Protein E.coli
    Rat Il17a-871R Recombinant Rat Il17a protein, His-tagged E.coli His
    Rat Il17a-489R Recombinant Rat Il17a protein E.coli N/A
    Rat Il17a-89R Recombinant Rat Interleukin 17A E.coli N/A
    Rat IL17A-142R Recombinant Rat IL-17AF Heterodimer Protein E.coli
    Rat Il17a-492R Recombinant Rat Interleukin-17AF Heterodimer E.coli N/A
    Rhesus Macaque IL17A&IL17F-262R Recombinant Rhesus IL17A/IL17F protein, His-tagged HEK293 His
    Rhesus Macaque IL17A-261R Recombinant Rhesus IL17A protein Insect Cell N/A
    Rhesus macaque IL17A-3092R Recombinant Rhesus macaque IL17A protein, GST-tagged E.coli GST
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL17A Related Articles
    • IL17A Related Gene Family
    • IL17A Related Research Area

    IL17A involved in several pathways and played different roles in them. We selected most pathways IL17A participated on our site, such as Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionCCR3;TNFRSF14;CCL28;LIFRA;TGFBR2;IFNB1;CXCL8;LEPB;CXCR4A
    Inflammatory bowel disease (IBD)IL12A;STAT1;HLA-DMA;H2-AB1;IL22;HLA-DQA1;TBX21;IL23;IL1A
    Rheumatoid arthritisHLA-DRA;ATP6V0A1;H2-AB1;TEK;ATP6V0E1;HLA-DRB3;IL1B;CXCL6;HLA-DMB

    IL17A has several biochemical functions, for example, cytokine activity, cytokine receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17A itself. We selected most functions IL17A had, and list some proteins which have the same functions with IL17A. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityCSF3;INHBE;INHBA;IFNL3;SLURP1;BMP2B;NRG1;GPI1;IL1F10
    cytokine receptor bindingIFNA21;MIF;IFNA12;IL17A/F2;IFN-a;IL17B;IL17D;IL17C;IFNA14
    protein bindingSIX3;CHD;ARFGAP1;TAF12;GNB2;LMX1B;MED6;MRM1;FAP

    IL17A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17A.


    Mease, PJ; et al. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. CURRENT OPINION IN RHEUMATOLOGY 27:127-133(2015).
    Ji, PY; Hu, HL; et al. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. PARASITOLOGY RESEARCH 114:613-624(2015).
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    Could you explain the role of IL17A in autoimmune disease progression using animal models? 05/22/2022

    Animal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.

    Can you detail the protocols for inducing IL17A expression in T cells in vitro? 01/02/2021

    Inducing IL17A expression in T cells involves culturing them with specific cytokines.

    What strategies elucidate IL17A's impact on tissue-specific inflammation in human samples? 02/17/2020

    Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.

    Can you elaborate on the use of neutralizing antibodies in blocking IL17A's effects? 06/12/2019

    Neutralizing antibodies block IL17A's effects in cell cultures or animal models.

    How does one perform a multiplex cytokine assay to quantify IL17A along with other cytokines? 12/13/2018

    Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.

    How is the IL17A receptor (IL17RA) signaling pathway activated and studied? 11/23/2018

    IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.

    What are the methods to investigate the impact of IL17A on epithelial barrier integrity? 08/09/2018

    Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.

    How is IL17A's contribution to neutrophil recruitment assessed in inflammatory models? 06/25/2018

    Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.

    What techniques are used to analyze IL17A-producing cell populations within a tissue? 06/22/2018

    Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.

    What experimental design is employed to understand IL17A's involvement in cancer development? 03/23/2018

    Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.

    Customer Reviews (3)

    Write a review

      Good for receptor studies. -


        Effective in Th17 differentiation. -


          High bioactivity in various tissue types. -

          Ask a Question for All IL17A Products

          Required fields are marked with *

          My Review for All IL17A Products

          Required fields are marked with *


          Stay Updated on the
          Latest Bioscience Trends

          Copyright © 2023 Creative BioMart. All Rights Reserved.

          Terms and Conditions        Privacy Policy