Active Recombinant Human IL29, HIgG1 Fc-tagged

Cat.No. : IL29-003H
Product Overview : The extracellular domain of human IL-29 (AAI17483.1)(Gly20-Thr200) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell.
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Description : This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured in an anti-viral assay.
Molecular Mass : 46KDa (monomer)
AA Sequence : Gly20-Thr200
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : IL29 interleukin 29 (interferon, lambda 1) [ Homo sapiens ]
Official Symbol : IL29
Synonyms : IL29; interleukin 29 (interferon, lambda 1); interleukin 29; interleukin-29; IFNL1; IL 29; IFN-lambda-1; cytokine Zcyto21; interferon lambda-1; interferon-lambda-1; interferon, lambda 1; IL-29;
Gene ID : 282618
mRNA Refseq : NM_172140
Protein Refseq : NP_742152
MIM : 607403
UniProt ID : Q8IU54
Chromosome Location : 19q13.13
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity; interleukin-28 receptor binding; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
10/12/2022

    Storage conditions are very simple and can be stored for a long time.

    04/30/2022

      Anti-pollution ability is very strong, not easy to be polluted.

      09/12/2019

        Labeling effect is very good, can be fluorescent labeling and so on.

        Q&As (6)

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        How should the dose of IL29 be determined? 08/01/2022

        The dose of IL29 should be determined according to the specific disease and patient situation, and the most appropriate dose usually needs to be determined through clinical trials and individualized treatment.

        What is the difference between IL29 and IL28? 06/02/2021

        IL29 and IL28 are two similar interferons that are similar in structure and function, but with some minor differences such as receptor affinity and signaling pathways.

        What are the advantages of IL29 compared with traditional drugs? 03/22/2021

        IL29 is highly targeted and safe, and can stimulate the response of the own immune system, which has better therapeutic effect and fewer side effects than traditional drugs.

        Does IL29 have antioxidant effects? 01/11/2021

        At present, there are no clear studies to prove that IL29 has a direct antioxidant effect, but it may indirectly affect oxidative stress response by regulating immune system function.

        Recombinant IL29 has potential in the treatment of which autoimmune diseases? 07/06/2020

        IL29 has potential in the treatment of rheumatoid arthritis, hepatitis B, psoriasis and other autoimmune diseases.

        Are there side effects of IL29? 04/18/2020

        It may cause some mild side effects, such as fever, fatigue, headache, etc., but it is generally reversible, and serious side effects are rare.

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