Active Recombinant Human IL29, MIgG2a Fc-tagged
| Cat.No. : | IL29-001H |
| Product Overview : | The extracellular domain of human IL-29 (AAI17483.1)(Gly20-Thr200) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
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| Description : | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). |
| Source : | CHO cell |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured in an anti-viral assay. |
| Molecular Mass : | 46KDa (monomer) |
| AA Sequence : | Gly20-Thr200 |
| Endotoxin : | <0.06 eu/μg as determined by lal test.> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Gene Name : | IL29 interleukin 29 (interferon, lambda 1) [ Homo sapiens ] |
| Official Symbol : | IL29 |
| Synonyms : | IL29; interleukin 29 (interferon, lambda 1); interleukin 29; interleukin-29; IFNL1; IL 29; IFN-lambda-1; cytokine Zcyto21; interferon lambda-1; interferon-lambda-1; interferon, lambda 1; IL-29; |
| Gene ID : | 282618 |
| mRNA Refseq : | NM_172140 |
| Protein Refseq : | NP_742152 |
| MIM : | 607403 |
| UniProt ID : | Q8IU54 |
| Chromosome Location : | 19q13.13 |
| Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
| Function : | cytokine activity; interleukin-28 receptor binding; receptor binding; |
Products Types
| ◆ Recombinant Protein | ||
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| IL29-131H | Active Recombinant Human IL29 Protein (Pro23-Thr200), C-His tagged, Animal-free, Carrier-free | +Inquiry |
| IL29-1034P | Recombinant Pig IL29 Protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| IL29-5228HCL | Recombinant Human IL29 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionThe dose of IL29 should be determined according to the specific disease and patient situation, and the most appropriate dose usually needs to be determined through clinical trials and individualized treatment.
IL29 and IL28 are two similar interferons that are similar in structure and function, but with some minor differences such as receptor affinity and signaling pathways.
IL29 is highly targeted and safe, and can stimulate the response of the own immune system, which has better therapeutic effect and fewer side effects than traditional drugs.
At present, there are no clear studies to prove that IL29 has a direct antioxidant effect, but it may indirectly affect oxidative stress response by regulating immune system function.
IL29 has potential in the treatment of rheumatoid arthritis, hepatitis B, psoriasis and other autoimmune diseases.
It may cause some mild side effects, such as fever, fatigue, headache, etc., but it is generally reversible, and serious side effects are rare.
Customer Reviews (3)
Write a reviewDetect whether recombinant IL-29 protein causes immune responses, including allergic reactions, to avoid potential safety concerns. -
The biological activity of recombinant IL-29 protein was verified by cell experiments, including its effects on target cells, such as inhibiting viral proliferation and enhancing immune response. At the same time, to understand its interaction with relevant signaling pathways, to further evaluate its efficacy. -
It has the function of inhibiting virus proliferation and enhancing immune response. -
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