IL29

  • Official Full Name

    interleukin 29 (interferon, lambda 1)

  • Background

    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
  • Synonyms

    IL29; interleukin 29 (interferon, lambda 1); interleukin 29; interleukin-29; IFNL1; IL 29; IFN-lambda-1; cytokine Zcyto21; interferon lambda-1; interferon-lambda-1; interferon, lambda 1; IL-29;
    • Type:
    • Recombinant Proteins
    • Transfected Stable Cell Lines
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Pig
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human cells
    • Mammalian cells
    • Tag :
    • Fc
    • His
    • His (Fc)
    • Avi
    • SUMO
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL29-602H Recombinant Human Interleukin 29 (interferon, lambda 1) HEK293 N/A
    Human IL29-381H Recombinant Human IL29 protein, His-tagged HEK293 His
    Human IL29-003H Active Recombinant Human IL29, HIgG1 Fc-tagged CHO Fc
    Human IL29-37H Interleukin-29 (Interferon Lamda 1) Reference standard N/A
    Human IL29-222H Recombinant Human Interleukin 29 (Interferon, Lambda 1), His-tagged Mammalian cells His
    Human IL29-14194H Recombinant Human IL29, His-tagged E.coli His
    Human IL29-100H Recombinant Human IL29 protein E.coli N/A
    Human IL29-5228HCL Recombinant Human IL29 293 Cell Lysate HEK293 N/A
    Human IL29-3152H-B Recombinant Human IL29 Protein Pre-coupled Magnetic Beads HEK293
    Human IL29-001H Active Recombinant Human IL29, MIgG2a Fc-tagged CHO Fc
    Human IL29-5200H Recombinant Human IL29 Protein E.coli N/A
    Human IL29-002H Active Recombinant Human IL29, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL29-2309H Recombinant Human IL29 Protein, His-tagged E.coli N-His
    Human IL29-4621H Recombinant Human IL29 protein, His-SUMO-tagged E.coli His-SUMO
    Human IL29-34H Recombinant Human IL29 Protein, Animal Free Human cells
    Human IL29-3152H Recombinant Human IL29 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL29-513H Recombinant Human IL29 Protein
    Pig IL29-1034P Recombinant Pig IL29 Protein, His-tagged E.coli N-His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL29 Related Articles
    • IL29 Related Research Area

    IL29 involved in several pathways and played different roles in them. We selected most pathways IL29 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL29 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionIL1A;CCL4L2;IFNA14;CD27;GM2506;EDA2R;VEGFB;TNFRSF4;CXCL6
    Jak-STAT signaling pathwayIL21R;IFNA10;STAM;IL22RA2;SOCS6B;CISHB;IL10RA;PTPN2;LEP

    IL29 has several biochemical functions, for example, cytokine activity, interleukin-28 receptor binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL29 itself. We selected most functions IL29 had, and list some proteins which have the same functions with IL29. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityFAM3D;SCGB3A1;IFN-a;TNFSF18;Flt3l;BMP2;GM13279;OSM;IFNPHI1
    interleukin-28 receptor binding
    receptor bindingLGI1;Ifnl2;TGFB2;ABL1;GUSB;PLA2G1B;CNPY4;CADM1B;LRRC4B

    IL29 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL29 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL29.

    Ghoneum, M; Agrawal, S; et al. MGN-3/BIOBRAN ENHANCES GENERATION OF CYTOTOXIC CD8+T CELLS VIA UPREGULATION OF DEC-205 EXPRESSION ON DENDRITIC CELLS. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 27:523-530(2014).
    Zhang, LL; Jilg, N; et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. JOURNAL OF HEPATOLOGY 55:289-298(2011).
    WILLIAMS, RC; MALONE, CC; et al. IGG ANTI-F(AB')(2) ANTIBODIES FROM SLE PATIENTS REACT WITH IMMUNODOMINANT RESIDUES IN KAPPA-CDRS, BUT SHOW REDUCED C-KAPPA REGION REACTIVITY. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY 77:366-373(1995).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    How should the dose of IL29 be determined? 08/01/2022

    The dose of IL29 should be determined according to the specific disease and patient situation, and the most appropriate dose usually needs to be determined through clinical trials and individualized treatment.

    What is the difference between IL29 and IL28? 06/02/2021

    IL29 and IL28 are two similar interferons that are similar in structure and function, but with some minor differences such as receptor affinity and signaling pathways.

    What are the advantages of IL29 compared with traditional drugs? 03/22/2021

    IL29 is highly targeted and safe, and can stimulate the response of the own immune system, which has better therapeutic effect and fewer side effects than traditional drugs.

    Does IL29 have antioxidant effects? 01/11/2021

    At present, there are no clear studies to prove that IL29 has a direct antioxidant effect, but it may indirectly affect oxidative stress response by regulating immune system function.

    Recombinant IL29 has potential in the treatment of which autoimmune diseases? 07/06/2020

    IL29 has potential in the treatment of rheumatoid arthritis, hepatitis B, psoriasis and other autoimmune diseases.

    Are there side effects of IL29? 04/18/2020

    It may cause some mild side effects, such as fever, fatigue, headache, etc., but it is generally reversible, and serious side effects are rare.

    Customer Reviews (3)

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    Reviews
    10/12/2022

      Detect whether recombinant IL-29 protein causes immune responses, including allergic reactions, to avoid potential safety concerns. -

      04/30/2022

        The biological activity of recombinant IL-29 protein was verified by cell experiments, including its effects on target cells, such as inhibiting viral proliferation and enhancing immune response. At the same time, to understand its interaction with relevant signaling pathways, to further evaluate its efficacy. -

        09/12/2019

          It has the function of inhibiting virus proliferation and enhancing immune response. -

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