IL29
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Official Full Name
interleukin 29 (interferon, lambda 1)
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Background
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). -
Synonyms
IL29; interleukin 29 (interferon, lambda 1); interleukin 29; interleukin-29; IFNL1; IL 29; IFN-lambda-1; cytokine Zcyto21; interferon lambda-1; interferon-lambda-1; interferon, lambda 1; IL-29;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL29 Related Articles
- IL29 Related Research Area
IL29 involved in several pathways and played different roles in them. We selected most pathways IL29 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL29 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL1A;CCL4L2;IFNA14;CD27;GM2506;EDA2R;VEGFB;TNFRSF4;CXCL6 |
| Jak-STAT signaling pathway | IL21R;IFNA10;STAM;IL22RA2;SOCS6B;CISHB;IL10RA;PTPN2;LEP |
IL29 has several biochemical functions, for example, cytokine activity, interleukin-28 receptor binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL29 itself. We selected most functions IL29 had, and list some proteins which have the same functions with IL29. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | FAM3D;SCGB3A1;IFN-a;TNFSF18;Flt3l;BMP2;GM13279;OSM;IFNPHI1 |
| interleukin-28 receptor binding | |
| receptor binding | LGI1;Ifnl2;TGFB2;ABL1;GUSB;PLA2G1B;CNPY4;CADM1B;LRRC4B |
IL29 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL29 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL29.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe dose of IL29 should be determined according to the specific disease and patient situation, and the most appropriate dose usually needs to be determined through clinical trials and individualized treatment.
IL29 and IL28 are two similar interferons that are similar in structure and function, but with some minor differences such as receptor affinity and signaling pathways.
IL29 is highly targeted and safe, and can stimulate the response of the own immune system, which has better therapeutic effect and fewer side effects than traditional drugs.
At present, there are no clear studies to prove that IL29 has a direct antioxidant effect, but it may indirectly affect oxidative stress response by regulating immune system function.
IL29 has potential in the treatment of rheumatoid arthritis, hepatitis B, psoriasis and other autoimmune diseases.
It may cause some mild side effects, such as fever, fatigue, headache, etc., but it is generally reversible, and serious side effects are rare.
Customer Reviews (3)
Write a reviewDetect whether recombinant IL-29 protein causes immune responses, including allergic reactions, to avoid potential safety concerns. -
The biological activity of recombinant IL-29 protein was verified by cell experiments, including its effects on target cells, such as inhibiting viral proliferation and enhancing immune response. At the same time, to understand its interaction with relevant signaling pathways, to further evaluate its efficacy. -
It has the function of inhibiting virus proliferation and enhancing immune response. -
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