IL29
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Official Full Name
interleukin 29 (interferon, lambda 1) -
Overview
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). -
Synonyms
IL29;interleukin 29 (interferon, lambda 1);interleukin 29;interleukin-29;IFNL1;IL 29;IFN-lambda-1;cytokine Zcyto21;interferon lambda-1;interferon-lambda-1;interferon, lambda 1;IL-29
Recombinant Proteins
- Human
- Pig
- E.coli
- HEK293
- CHO
- Human Cells
- Mammalian Cells
- His
- Fc
- Non
- Avi
- SUMO
Involved Pathway
IL29 involved in several pathways and played different roles in them. We selected most pathways IL29 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL29 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | GH2,SOCS4,Il2,IFNAR2,IL20,GRB2B,OSMR,IFNA17,PIK3CB,IL12RB2 |
| Cytokine-cytokine receptor interaction | IL23R,BMPR2,CNTF,IL15,FLT3LG,CCL4L2,CXCR7,IFNA17,IL21R.1,IL13RA1 |
Protein Function
IL29 has several biochemical functions, for example, cytokine activity,interleukin-28 receptor binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL29 itself. We selected most functions IL29 had, and list some proteins which have the same functions with IL29. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | MTSS1,CALCA,CD160,TENC1,FGF8A,UFD1L,CADM1B,LAMA3,CNPY3,APLN |
| cytokine activity | Ctf2,IFNA8,INHBAB,LFT1,LFT2,VSTM1,GDF1,CMTM2B,CCL38A.5,HMGB1A |
Interacting Protein
IL29 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL29 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL29.
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References
- Ghoneum, M; Agrawal, S; et al. MGN-3/BIOBRAN ENHANCES GENERATION OF CYTOTOXIC CD8+T CELLS VIA UPREGULATION OF DEC-205 EXPRESSION ON DENDRITIC CELLS. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 27:523-530(2014).
- Zhang, LL; Jilg, N; et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. JOURNAL OF HEPATOLOGY 55:289-298(2011).
- WILLIAMS, RC; MALONE, CC; et al. IGG ANTI-F(AB')(2) ANTIBODIES FROM SLE PATIENTS REACT WITH IMMUNODOMINANT RESIDUES IN KAPPA-CDRS, BUT SHOW REDUCED C-KAPPA REGION REACTIVITY. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY 77:366-373(1995).
