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Active Recombinant Human IL8 (28-99aa)

Cat.No. : IL8-360H
Product Overview : Human IL8 (P10145, 28 a.a. - 99 a.a.) partial recombinant protein expressed in Escherichia coli.
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  • Gene Information
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Cat. No. : IL8-360H
Description : Interleukin-8 (IL8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene.
Sequence : SAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Theoretical MW (kDa) : 8
Form : Lyophilized
Preparation Method : E. coli expression system
Purity : > 95% by SDS-PAGE and HPLC
Endotoxin Level : < 0.1 ng/ug (1 EU/ug)
Activity : Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/mL.
Application : SDS-PAGE
Storage Buffer : Lyophilized from PBS, pH 7.5
Storage : Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at -20°C. Aliquot to avoid repeated freezing and thawing.
Unitprot ID : P10145
Gene Name : IL8 interleukin 8 [ Homo sapiens ]
Official Symbol : IL8
Synonyms : IL8; 3-10C; AMCF-I; CXCL8; Emoctakin; GCP-1; GCP1; IL-8; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8; TSG-1; b-ENAP; emoctakin; C-X-C motif chemokine 8; Granulocyte chemotactic protein 1; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; Neutrophil-activating protein 1; Protein 3-10C; T cell chemotactic factor; T-cell chemotactic factor; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; interleukin 8; lymphocyte-derived neutrophil-activating factor; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; Interleukin-8
Gene ID : 3576
mRNA Refseq : NM_000584
Protein Refseq : NP_000575
MIM : 146930
Chromosome Location : 4q13-q21
Pathway : Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Leukocyte transendothelial migration; Toll-like receptor signaling pathway; Signaling by GPCR
Function : chemokine activity; interleukin-8 receptor binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of IL8 in the immune system? 08/31/2021

Acts as a chemical messenger in the immune system that regulates inflammation and attracts immune cells such as white blood cells.

How about the effect of IL8 on tumor? 06/01/2020

Regulating tumor microenvironment, promoting tumor growth and metastasis, and can be used in tumor therapy research.

What is the relationship between IL8 and inflammatory response? 01/18/2020

IL8 plays a role in regulating and promoting the migration and activation of inflammatory cells in the inflammatory response.

Which diseases can be treated with IL8? 12/02/2019

Can be used to treat inflammatory diseases (such as rheumatoid arthritis, psoriasis), tumors (such as lung cancer, breast cancer) and other diseases.

Is IL8 relevant to immunotherapy? 03/18/2019

Yes, IL8 is closely related to immunotherapy, which can enhance the role of the immune system and assist in the treatment of certain diseases.

By what method is IL8 generally prepared? 02/03/2019

IL8 is generally prepared by gene recombination technology, and the IL8 gene is introduced into the appropriate expression system, and then expressed and purified.

Customer Reviews (3)

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Reviews
10/28/2022

    IL8 has good fluorescence and absorption properties.

    11/29/2020

      NIPBL has good stability in different environments and is not easy to degrade.

      04/17/2019

        Through animal models or in vitro experiments to evaluate the mechanism of the recombinant protein in related diseases, we found that the effect is very good.

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