Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 647 conjugated

• Cat.No.: PDCD1-189HAF647
• Product Overview: The Alexa Fluor 647 conjugated extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Specification

• Description: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
• Source: CHO
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Bio-activity: Shows the biological function of the CD279 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
• Endotoxin: < 0.06 EU/ μg protein
• Purity: ≥98 % by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 647 via amines
  Excitation = 650 nm
  Emission = 668 nm
• Storage: Avoid freeze/thaw cycles.
  Short Term Storage: +4 centigrade
  Long Term Storage: -20 centigrade
• Concentration: 100 μg/mL
• Storage Buffer: Lyophilized from 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.

Gene Information

• Gene Name: PDCD1 programmed cell death 1 [ Homo sapiens (human) ]
• Official Symbol: PDCD1
• Synonyms: PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; programmed cell death 1; programmed cell death protein 1; protein PD-1
• Gene ID: 5133
• mRNA Refseq: NM_005018
• Protein Refseq: NP_005009
• MIM: 600244
• UniProt ID: Q15116