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PDCD1

  • Official Full Name

    Pdcd1 programmed cell death 1

  • Overview

    CD279 is a 50-55 kD immunoglobulin superfamily member, also known as programmed death-1 (PD-1). PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily.
  • Synonyms

    PDCD1; programmed cell death 1; programmed cell death protein 1; mPD-1; protein PD-1; PD-1; Pdc1; Ly101;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Dog
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Monkey
  • Mouse
  • Porcine
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • CHO
  • CHO cells
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Wheat Germ
  • Avi|Fc
  • Avi|Fc|His
  • C
  • 6×His
  • 6His
  • Avi
  • Fc
  • hFc
  • His
  • mFc
  • DDK
  • DDK|His
  • DYKDDDDK
  • FC
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • hIgG
  • HIgG1 Fc
  • His (Fc)
  • His\Avi
  • His|Avi
  • His|Fc
  • His|GST
  • SUMO
  • human|IgG1|Fc
  • IgG2a Fc
  • lFc
  • LIgG2b Fc
  • MIgG2a Fc
  • Mouse|IgG2a|Fc
  • mutant HIgG1|Fc
  • Myc
  • N/A
  • N
  • Strep
  • Tag Free
  • Twin
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDCD1-172H Active Recombinant Human PDCD1, no tag HEK293 N/A Leu 25 - Leu 288
Human PDCD1-032H Active Recombinant Human PDCD1, HIgG1 Fc-tagged CHO Fc
Human PDCD1-191H Active Recombinant Human PDCD1 Protein, Fc-tagged CHO Fc
Human PDCD1-031H Active Recombinant Human PDCD1, MIgG2a Fc-tagged CHO Fc
Human PDCD1-034H Active Recombinant Human PDCD1, HIgG1 Fc-tagged, mutant CHO Fc
Human PDCD1-190H Active Recombinant Human PDCD1 Protein, His-tagged CHO His
Human PDCD1-28H Active Recombinant Human PDCD1 protein, His-tagged HEK293 His
Human PDCD1-031HAF488 Active Recombinant Human PDCD1 Protein, MIgG2a mFc-tagged, Alexa Fluor 488 conjugated CHO mFc
Human PDCD1-4461H Active Recombinant Human PDCD1 protein, His-tagged Mammalian cell His 25-167aa
Human PDCD1-057H Active Recombinant Human PDCD1 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Leu25-Thr168
Human PDCD1-361H Active Recombinant Human PDCD1 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 LIgG2b Fc Leu 25 - Gln 167
Human PDCD1-032HAF488 Active Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 488 conjugated CHO hFc
Human PDCD1-189HAF488 Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 488 conjugated CHO Fc
Human PDCD1-21H Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor® 488 conjugated NS0 Fc
Human PDCD1-051H Active Recombinant Human PDCD1 protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Leu25-Thr168
Human PDCD1-189HF Active Recombinant Human PDCD1 Protein, Fc-tagged, FITC conjugated CHO Fc
Human PDCD1-191HAF488 Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 488 conjugated CHO Fc 379
Human PDCD1-034HAF488 Active Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 488 conjugated CHO hFc
Human PDCD1-22H Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor® 647 conjugated NS0 Fc
Human PDCD1-032HAF555 Active Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 555 conjugated CHO hFc
Human PDCD1-031HF Active Recombinant Human PDCD1 Protein, MIgG2a mFc-tagged, FITC conjugated CHO mFc
Human PDCD1-031HAF647 Active Recombinant Human PDCD1 Protein, MIgG2a mFc-tagged, Alexa Fluor 647 conjugated CHO mFc
Human PDCD1-031HAF555 Active Recombinant Human PDCD1 Protein, MIgG2a mFc-tagged, Alexa Fluor 555 conjugated CHO mFc
Human PDCD1-034HAF647 Active Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 647 conjugated CHO hFc
Human PDCD1-173H Active Recombinant Human PDCD1 protein, His-tagged HEK293 His Leu 25 - Leu 288
Human PDCD1-191HAF647 Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 647 conjugated CHO Fc 379
Human PDCD1-034HAF555 Active Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 555 conjugated CHO hFc
Human PDCD1-189HAF555 Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 555 conjugated CHO Fc
Human PDCD1-0614H Active Recombinant Human PDCD1 protein, lFc-tagged HEK293 lFc Leu25-Gln167
Human PDCD1-034HF Active Recombinant Human PDCD1 Protein, hFc-tagged, FITC conjugated CHO hFc
Human PDCD1-191HAF555 Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 555 conjugated CHO Fc 379
Human PDCD1-01H Active Recombinant Human PDCD1 Protein HEK293 Protein fragment
Human PDCD1-032HAF647 Active Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 647 conjugated CHO hFc
Human PDCD1-191HF Active Recombinant Human PDCD1 Protein, Fc-tagged, FITC conjugated CHO Fc 379
Human PDCD1-189HAF647 Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 647 conjugated CHO Fc
Human PDCD1-032HF Active Recombinant Human PDCD1 Protein, hFc-tagged, FITC conjugated CHO hFc
Human PDCD1-29487TH Recombinant Human PDCD1 Wheat Germ N/A 110 amino acids
Human PDCD1-1589H Recombinant Human PDCD1, GST-tagged E.coli GST 1-288aa
Human PDCD1-2943H Recombinant Human PDCD1 protein, GST-tagged Wheat Germ GST 1 a.a. - 288 a.a.
Human PDCD1-188H Recombinant Human PDCD1, Fc-tagged CHO Fc
Human PDCD1-472H Recombinant Human PDCD1 protein, His-tagged E.coli His 1 - 288 aa
Human PDCD1-822H Active Recombinant Human PDCD1, His tagged HEK293 His Met 1-Gln 167
Human PDCD1-821H Recombinant Human PDCD1 protein, Fc-tagged, low endotoxin (HPLC-verified) HEK293 human/IgG1/Fc 143
Human PDCD1-257H Recombinant Human PDCD1, His-tagged, Biotinylated HEK293 His
Human PDCD1-3244H Recombinant Human PDCD1, Fc-His tagged Human Cell Fc/His
Human PDCD1-839H Recombinant Human PDCD1 protein, His-tagged E.coli His Leu41~Ala132
Human PDCD1-189H Active Recombinant Human PDCD1, Fc-tagged CHO Fc
Human PDCD1-182H Recombinant Human PDCD1 Protein, DDK/His-tagged HEK293 DDK/His Leu25 - Gln167
Human PDCD1-217H Recombinant Human PDCD1, His-tagged HEK293 His
Human PDCD1-206H Recombinant Human PDCD1, His-tagged, C13&N15 Labeled HEK293 His
Human PDCD1-2873HCL Recombinant Human PDCD1 cell lysate Human Cell N/A
Human PDCD1-5224H Recombinant Human PDCD1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDCD1-259H Active Recombinant Human PDCD1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human PDCD1-258H Active Recombinant Human PDCD1 Protein, Fc-Avi-His-tagged, Biotinylated HEK293 Avi/Fc/His
Human PDCD1-822HAF488 Recombinant Human PDCD1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 154
Human PDCD1-188HAF488 Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 488 conjugated CHO Fc
Human PDCD1-2022H Recombinant Human PDCD1 Protein, His-tagged HEK293 His Leu25-Thr168
Human PDCD1-260H Active Recombinant Human PDCD1 Protein, Fc-Avi-tagged, Biotinylated HEK293 Avi/Fc
Human PDCD1-031HP Recombinant Human PDCD1 protein, MIgG2a Fc-tagged, R-PE labeled CHO MIgG2a Fc
Human PDCD1-821HF Recombinant Human PDCD1 Protein, hFc-tagged, FITC conjugated HEK293 hFc 143
Human PDCD1-188HP Recombinant Human PDCD1 protein, Fc-tagged, R-PE labeled CHO Fc
Human PDCD1-3244HP Recombinant Human PDCD1 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Human PDCD1-032HP Recombinant Human PDCD1 protein, HIgG1 Fc-tagged, R-PE labeled CHO HIgG1 Fc
Human PDCD1-822HF Recombinant Human PDCD1 Protein, His-tagged, FITC conjugated HEK293 His 154
Human PDCD1-821HP Recombinant Human PDCD1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human PDCD1-031HA Recombinant Human PDCD1 protein, MIgG2a Fc-tagged, APC labeled CHO MIgG2a Fc
Human PDCD1-034HP Recombinant Human PDCD1 protein, mutant HIgG1 Fc-tagged, R-PE labeled CHO mutant HIgG1/Fc
Human PDCD1-821HAF647 Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc 143
Human PDCD1-032HA Recombinant Human PDCD1 protein, HIgG1 Fc-tagged, APC labeled CHO HIgG1 Fc
Human PDCD1-034HA Recombinant Human PDCD1 protein, mutant HIgG1 Fc-tagged, APC labeled CHO mutant HIgG1/Fc
Human PDCD1-188HA Recombinant Human PDCD1 protein, Fc-tagged, APC labeled CHO Fc
Human PDCD1-822HAF647 Recombinant Human PDCD1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 154
Human PDCD1-3244HA Recombinant Human PDCD1 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Human PDCD1-821HA Recombinant Human PDCD1 protein, Fc-tagged, APC labeled HEK293 Fc
Human PDCD1-189HP Recombinant Human PDCD1 protein, Fc-tagged, R-PE labeled CHO Fc
Human PDCD1-821HAF555 Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc 143
Human PDCD1-362H Recombinant Human PDCD1 protein, Strep-tagged HEK293 Strep 143
Human PDCD1-3244HAF555 Recombinant Human PDCD1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 390
Human PDCD1-189HA Recombinant Human PDCD1 protein, Fc-tagged, APC labeled CHO Fc
Human PDCD1-822HAF555 Recombinant Human PDCD1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 154
Human PDCD1-931HG Active GMP Recombinant Human PDCD1 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human PD-1(NCBI Reference Sequence: NP_005009.2) was expressed with Fc tag at the C-terminal.
Human PDCD1-4409H Recombinant Human PDCD1 protein, His-SUMO-tagged E.coli His-SUMO 21-170aa
Human PDCD1-191HP Recombinant Human PDCD1 protein, Fc-tagged, R-PE labeled CHO Fc
Human PDCD1-4291M PDCD1 protein-coupled magnetic MicroBeads
Human PDCD1-3244HAF647 Recombinant Human PDCD1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 390
Human PDCD1-06H Active Recombinant Human PDCD1 Protein, hIgG-tagged HEK293 hIgG 21-170aa
Human PDCD1-191HA Recombinant Human PDCD1 protein, Fc-tagged, APC labeled CHO Fc
Human PDCD1-204H Recombinant Human PDCD1 Protein, PRO21-GLN167, ECD, Tag Free, Biotinylated HEK293 Tag Free PRO21-GLN167, ECD
Human PDCD1-3244HAF488 Recombinant Human PDCD1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 390
Human PDCD1-3244HB Recombinant Human PDCD1 protein, His-Fc-tagged, Biotinylated HEK293 His-Fc
Human PDCD1-355H Recombinant Human PDCD1 protein, Mouse IgG2a Fc-tagged (HPLC-verified) HEK293 Mouse/IgG2a/Fc 143
Human PDCD1-384H Recombinant Human PDCD1 Protein (Met1-Gln167), His-Fc-tagged, Biotinylated HEK293 His/Fc Met1-Gln167
Human PDCD1-821HAF488 Recombinant Human PDCD1 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc 143
Human PDCD1-116H Recombinant Human PDCD1 protein, Fc-Avi-tagged HEK293 Fc-Avi Leu25-Gln167
Human PDCD1-332H Recombinant Human PDCD1 protein, His-tagged (HPLC verified) HEK293 His Leu25-Gln167
Human PDCD1-932HG Active GMP Recombinant Human PDCD1 protein HEK293 DNA sequence encoding Human PD-1(NCBI Reference Sequence: NP_005009.2) was expressed with His tag at the C-terminal.
Human PDCD1-3244HF Recombinant Human PDCD1 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 390
Human PDCD1-02H Recombinant Human PDCD1 Protein, His-Tagged HEK293 His
Human PDCD1-892HL Recombinant Human PDCD1 protein, His-tagged, low endotoxin (HPLC-verified) HEK293 His Leu25-Gln167
Human PDCD1-15H Recombinant Human PDCD1 Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Pro21-Gln167
Human PDCD1-2613H Active Recombinant Human PDCD1 protein, hFc&His-tagged HEK293 hFc&His Leu25-Thr168
Human PDCD1-267H Recombinant Human PDCD1 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Leu25-Thr168
Human PDCD1-356H Active Recombinant Human PDCD1 protein, mFc-tagged HEK293 mFc Leu 25 - Gln 167
Human PDCD1-1173H Recombinant Human PDCD1 Protein, His-tagged HEK293F N-His Pro21-Val170
Human PDCD1-266H Recombinant Human PDCD1 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Leu25-Thr168
Human PDCD1-1624H-B Recombinant Human PDCD1 Protein Pre-coupled Magnetic Beads HEK293
Human PDCD1-215H Recombinant Human PDCD1 Protein, DYKDDDDK/His-tagged Human cells DYKDDDDK/His
Human PDCD1-1347H Recombinant Human PDCD1 Protein (Met1-Val170), C-His tagged Mammalian cells C-His Met1-Val170
Human PDCD1-187H Recombinant Human PDCD1 Protein, His\Avi-tagged Human Cell His\Avi
Human PDCD1-0611H Active Recombinant Human PDCD1 protein, Fc-His-tagged HEK293 FC/His Leu25-Gln167
Human PDCD1-151H Recombinant Human PDCD1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human PDCD1-0618H Active Recombinant Human PDCD1 protein, Fc-tagged HEK293 Fc Leu25-Gln167
Human PDCD1-122HFL Recombinant Full Length Human PDCD1 Protein, C-Flag-tagged Mammalian cells Flag
Human PDCD1-687H Recombinant Human PDCD1 Protein (Leu25-Gln167), C-hFc and 6×His-tagged HEK293 C-hFc and 6×His Leu25-Gln167
Human PDCD1-2564H Recombinant Human PDCD1 Protein, His-tagged E.coli N-His Pro21-Val170
Human PDCD1-689H Recombinant Human PDCD1 Protein (Phe24-Val170), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His Phe24-Val170
Human PDCD1-1624H Recombinant Human PDCD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDCD1-724HF Recombinant Full Length Human PDCD1 Protein, GST-tagged In Vitro Cell Free System GST 288 amino acids
Human PDCD1-0612H Active Recombinant Human PDCD1 protein, mFc-Avi-tagged, Biotinylated HEK293 mFc-Avi Leu25-Gln167
Human PDCD1-694H Recombinant Human PDCD1 Protein HEK293 288
Human PDCD1-0617H Active Recombinant Human PDCD1 protein, Twin-Strep-tagged HEK293 Twin-Strep Leu25-Gln167
Human PDCD1-695H Recombinant Human PDCD1 Protein, Fc-tagged HEK293 Fc 288
Human PDCD1-688H Recombinant Human PDCD1 Protein (Leu25-Gln167), C-6×His-tagged HEK293 C-6×His Leu25-Gln167
Human PDCD1-696H Recombinant Human PDCD1 Protein, Strep-tagged HEK293 Strep 288
Human PDCD1-4827H Recombinant Human PDCD1 Protein (Pro21-Gln167), C-His tagged Mammalian cells C-His Pro21-Gln167
Human PDCD1-697H Recombinant Human PDCD1 Protein HEK293 288
Human PDCD1-4688H Active Recombinant Human PDCD1 Protein, Fc-His-tagged, PE-Labeled HEK293 FC/His Leu 25 - Gln 167
Human PDCD1-2173H Active Recombinant Human PDCD1 protein, His-tagged HEK293 His Met1-Gln167
Human PDCD1-75H Recombinant Human PDCD1 Protein (G22-V170), C-6×His tagged E.coli C-6×His G22-V170
Human PDCD1-188HAF555 Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 555 conjugated CHO Fc
Human PDCD1-188HAF647 Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 647 conjugated CHO Fc
Human PDCD1-188HF Recombinant Human PDCD1 Protein, Fc-tagged, FITC conjugated CHO Fc
Mouse Pdcd1-041M Active Recombinant Mouse Pdcd1, MIgG2a Fc-tagged CHO Fc
Mouse Pdcd1-2303M Recombinant Mouse Pdcd1, Fc-His tagged Human Cell Fc/His
Mouse Pdcd1-205M Recombinant Mouse Pdcd1, Fc tagged, Biotinylated HEK293 Fc
Mouse Pdcd1-823M Active Recombinant Mouse Pdcd1 protein, His-tagged HEK293 His Met1-Gln167
Mouse Pdcd1-160M Active Recombinant Mouse Pdcd1 protein(Met1-Gln167), hFc-tagged HEK293 C-hFc Met1-Gln167
Mouse PDCD1-2628MCL Recombinant Mouse PDCD1 cell lysate Human Cell N/A
Mouse Pdcd1-206M Active Recombinant Mouse Pdcd1 Protein, Fc-Avi-tagged, Biotinylated HEK293 Avi/Fc
Mouse Pdcd1-4730M Recombinant Mouse Pdcd1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pdcd1-823MB Active BiotinylatedRecombinant Mouse Pdcd1 protein(Met1-Gln167), His-tagged HEK293 C-His Met1-Gln167
Mouse PDCD1-369M Active Recombinant Mouse PDCD1 protein, mFc-tagged HEK293 mFc Ser 21 - Gln 167
Mouse Pdcd1-823MAF488 Recombinant Mouse Pdcd1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 154
Mouse Pdcd1-2303MAF488 Recombinant Mouse Pdcd1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 391
Mouse PDCD1-625M Recombinant Mouse PDCD1 Protein, DDK/His-tagged HEK293 DDK/His
Mouse PDCD1-370M Active Recombinant Mouse PDCD1 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc Leu 25 - Gln 167
Mouse Pdcd1-2303MAF555 Recombinant Mouse Pdcd1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 391
Mouse PDCD1-698M Recombinant Mouse PDCD1 Protein HEK293 288
Mouse PDCD1-699M Recombinant Mouse PDCD1 Protein, Fc-tagged HEK293 Fc 288
Mouse PDCD1-801M Recombinant Mouse PDCD1 protein, His-tagged HEK293 His Leu25-Gln167
Mouse PDCD1-700M Recombinant Mouse PDCD1 Protein, IgG2a Fc-tagged HEK293 IgG2a Fc 288
Mouse Pdcd1-4729M Recombinant Mouse Pdcd1 Protein, DDK/His-tagged HEK293 DDK/His Leu25 – Gln167
Mouse PDCD1-3270M Recombinant Mouse PDCD1 protein, His-tagged E.coli His Leu25~Met169
Mouse Pdcd1-823MAF555 Recombinant Mouse Pdcd1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 154
Mouse PDCD1-691M Recombinant Mouse PDCD1 Protein, Fc-tagged, Biotinylated HEK293 Fc 288
Mouse Pdcd1-823MAF647 Recombinant Mouse Pdcd1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 154
Mouse Pdcd1-2303MF Recombinant Mouse Pdcd1 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 391
Mouse Pdcd1-823MF Recombinant Mouse Pdcd1 Protein, His-tagged, FITC conjugated HEK293 His 154
Mouse Pdcd1-2303MAF647 Recombinant Mouse Pdcd1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 391
Mouse Pdcd1-5725M Recombinant Mouse Pdcd1 Protein (Leu25-Gln167), C-Fc tagged Mammalian cells C-Fc Leu25-Gln167
Mouse Pdcd1-6766M Recombinant Mouse Pdcd1 Protein (Leu25-Gln167), C-His tagged Mammalian cells C-His Leu25-Gln167
Mouse PDCD1-0616M Active Recombinant Mouse PDCD1 protein, Fc-tagged HEK293 Fc Leu25-Gln167
Rat Pdcd1-560R Recombinant Rat Pdcd1 protein, Fc-tagged HEK293 human/IgG1/Fc Leu25-Gln167
Rat PDCD1-982R Active Recombinant Rat PDCD1 protein, His-tagged HEK293 His Leu 25 - Gln 167
Rat Pdcd1-840R Recombinant Rat Pdcd1 protein, His & GST-tagged E.coli His/GST Pro39~Ser266 (Accession # D3ZIN8)
Rat PDCD1-001RCL Recombinant Rat PDCD1 cell lysate Human Cell N/A
Rat Pdcd1-560RAF488 Recombinant Rat Pdcd1 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Leu25-Gln167
Rat PDCD1-703R Recombinant Rat PDCD1 Protein HEK293 287
Rat Pdcd1-560RF Recombinant Rat Pdcd1 Protein, hFc-tagged, FITC conjugated HEK293 hFc Leu25-Gln167
Rat PDCD1-704R Recombinant Rat PDCD1 Protein, Fc-tagged HEK293 Fc 287
Rat PDCD1-1033R Active Recombinant Rat PDCD1 protein(Met1-Gln167), hFc-tagged HEK293 C-hFc Met1-Gln167
Rat Pdcd1-560RAF555 Recombinant Rat Pdcd1 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Leu25-Gln167
Rat Pdcd1-560RAF647 Recombinant Rat Pdcd1 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Leu25-Gln167
Monkey PDCD1-1222RF Active Recombinant Monkey PDCD1 Protein, His-tagged, FITC conjugated HEK293 His 178
Monkey PDCD1-1222RAF488 Active Recombinant Monkey PDCD1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 178
Monkey PDCD1-1222RAF647 Active Recombinant Monkey PDCD1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 178
Monkey PDCD1-1222RAF555 Active Recombinant Monkey PDCD1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 178
Monkey PDCD1-1223CAF488 Recombinant Monkey PDCD1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Leu25-Gln167
Monkey PDCD1-1221RAF488 Recombinant Monkey PDCD1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 381
Monkey PDCD1-1223CAF555 Recombinant Monkey PDCD1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Leu25-Gln167
Monkey PDCD1-1221RF Recombinant Monkey PDCD1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 381
Monkey PDCD1-1221RAF647 Recombinant Monkey PDCD1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 381
Monkey PDCD1-1223CAF647 Recombinant Monkey PDCD1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Leu25-Gln167
Monkey PDCD1-1223CF Recombinant Monkey PDCD1 Protein, Fc-tagged, FITC conjugated HEK293 Fc Leu25-Gln167
Monkey PDCD1-1221RAF555 Recombinant Monkey PDCD1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 381
Rabbit PDCD1-371R Active Recombinant Rabbit PDCD1 protein, His-tagged HEK293 His Leu 25 - Gln 167
Rabbit PDCD1-701R Recombinant Rabbit PDCD1 Protein HEK293 289
Rabbit PDCD1-372R Recombinant Rabbit PDCD1 protein, Fc-tagged HEK293 human/IgG1/Fc 143
Rabbit PDCD1-702R Recombinant Rabbit PDCD1 Protein, Fc-tagged HEK293 Fc 289
Rabbit PDCD1-0615R Active Recombinant Rabbit PDCD1 protein, Fc-tagged HEK293 Fc Leu25-Gln167
Dog PDCD1-1057CAF555 Active Recombinant Canine PDCD1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 383
Dog PDCD1-1057CF Active Recombinant Canine PDCD1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 383
Dog PDCD1-1057CAF647 Active Recombinant Canine PDCD1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 383
Dog PDCD1-1057CAF488 Active Recombinant Canine PDCD1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 383
Canine PDCD1-1057C Active Recombinant Canine PDCD1 protein(Met1-Leu169), hFc-tagged HEK293 C-hFc Met1-Leu169
Canine PDCD1-0610C Active Recombinant Canine PDCD1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu25-Gly168
Canine PDCD1-1174C Recombinant Canine PDCD1 protein(Met1-Gly168), His&Avi-tagged, Biotinylated HEK293 C-His&Avi Met1-Gly168
Canine PDCD1-384C Active Recombinant Canine PDCD1 protein, His-tagged HEK293 His Met1-Leu169
Canine PDCD1-2119C Recombinant Canine PDCD1 protein, His-tagged HEK293 His Leu 25 - Gly 168
Cynomolgus PDCD1-1223C Active Recombinant Cynomolgus PDCD1 protein, Fc-tagged HEK293 Fc Leu 25 - Gln 167
Cynomolgus PDCD1-1003C Active Recombinant Cynomolgus PDCD1 protein(Met1-Gln167), hFc&Avi-tagged, Biotinylated HEK293 C-hFc&Avi Met1-Gln167
Cynomolgus PDCD1-0613C Active Recombinant Cynomolgus PDCD1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu25-Gln167
Cynomolgus PDCD1-5223C Recombinant Cynomolgus PDCD1 protein, His-tagged HEK293 His 143
Cynomolgus Monkey PDCD1-775C Recombinant Cynomolgus PDCD1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PDCD1-519C Recombinant Cynomolgus Monkey PDCD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PDCD1-519C-B Recombinant Cynomolgus Monkey PDCD1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus monkey PDCD1-693C Recombinant Cynomolgus monkey PDCD1 Protein, Fc-tagged HEK293 Fc 288
Cynomolgus monkey PDCD1-692C Recombinant Cynomolgus monkey PDCD1 Protein HEK293 288
Macaca mulatta (Rhesus macaque) PDCD1-5399M Recombinant Rhesus macaque PDCD1 Protein (Pro21-Gln167), C-His tagged Mammalian cells C-His Pro21-Gln167
Porcine PDCD1-02P Active Recombinant Porcine PDCD1 Chimera Protein CHO
Porcine PDCD1-01P Active Recombinant Porcine PDCD1 Protein, His-Tagged CHO His
Rhesus PDCD1-1222R Active Recombinant Rhesus PDCD1 protein(Met1-Gln167), His-tagged HEK293 C-His Met1-Gln167
Rhesus PDCD1-1221R Active Recombinant Rhesus PDCD1 protein(Met1-Gln167), hFc-tagged HEK293 C-hFc Met1-Gln167
Rhesus Macaque PDCD1-3338R Recombinant Rhesus monkey PDCD1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PDCD1-3156R Recombinant Rhesus Macaque PDCD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDCD1-3156R-B Recombinant Rhesus Macaque PDCD1 Protein Pre-coupled Magnetic Beads HEK293
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What is PDCD1 protein?

PDCD1 (programmed cell death 1) gene is a protein coding gene which situated on the long arm of chromosome 2 at locus 2q37. PDCD1 is an immunosuppressive receptor expressed in activated T cells. PDCD1 is a member of the immunoglobulin superfamily and plays an important role in T cell inhibitory signaling. By binding to two ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), it is involved in regulating the function of T cells, in particular playing a key role in inducing and maintaining immune tolerance to itself. Structurally, PDCD1 protein is located in the plasma membrane of the cell and has a variety of post-translational modifications, including phosphorylation, ubiquitination, and n-glycosylation. The expression of PDCD1 is mainly on T cells and pre-B cells, especially after T cell activation, its expression level will increase. The PDCD1 protein is consisted of 288 amino acids and its molecular mass is approximately 31.6 kDa.

What is the function of PDCD1 protein?

The PDCD1 protein, also known as PD-1, is an important immunomodulatory molecule that is mainly expressed in the T cells of the immune system. The biological function of PD-1 protein mainly involves the following aspects:

Immune tolerance and autoimmune regulation. By interacting with its two ligands, PD-L1 and PD-L2, PD-1 regulates the activity of T cells, particularly playing a role in maintaining immune tolerance and preventing autoimmune reactions. When T cells are activated, the expression of PD-1 increases and, by binding to PD-L1 and PD-L2, inhibits the proliferation of T cells and the production of cytokines, thereby limiting the occurrence of autoimmune responses.

Anti-tumor immune response. In the tumor microenvironment, PD-1 binds to PD-L1 on the surface of tumor cells and inhibits the function of tumor-infiltrating T cells, leading to dysfunction and failure of T cells, thereby helping tumor cells evade the surveillance and attack of the immune system.

B cell function regulation. PD-1 also plays a role in the differentiation and maturation of B cells, influencing humoral immune responses by regulating B cell activation and antibody production.

PDCD1 Related Signaling Pathway

The PDCD1 protein is a membrane protein mainly expressed on immune cells, which plays a key role in regulating the activation and tolerance of the immune system. By binding to its ligands PD-L1 (B7-H1) and PD-L2 (B7-DC), PD-1 mainly participates in the following signaling pathways: T cell receptor (TCR) signaling pathway, PD-1 signaling can inhibit PI3K/Akt pathway, which is an important signaling pathway for promoting cell survival and metabolism. In T cells, this inhibition leads to functional failure and depletion. mTOR signaling pathway, NF-κB signaling pathway and JAK/STAT signaling pathway.

Mechanisms of PD-1_PD-L1 pathway in T cells.jpg

Fig1. Mechanisms of PD-1/PD-L1 pathway in T cells. (Xiaowei Liu, 2023)

PDCD1 Related Diseases

Tumors. The role of the PD-1/PD-L1 signaling pathway in a variety of tumors has been extensively studied, particularly in tumor immune escape. By expressing PD-L1 and binding to PD-1 on T cells, tumor cells inhibit the T-cell-mediated immune response, thereby promoting tumor growth and metastasis.

Autoimmune disease. PD-1 also plays an important role in autoimmune diseases. For example, in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), the expression level of PD-1 correlates with the severity of the disease.

Lentiviral infections, immune-related inflammatory diseases, and autoimmune eye diseases are also associated with the PD-1/PD-L1 signaling pathway.

Bioapplications of PDCD1

The application of PD-1 protein in the field of tumor therapy is the most extensive and the most in-depth. PD-1 inhibitors, including anti-PD-1 antibodies and anti-PD-L1 antibodies, can block the binding of PD-1 to its ligand, relieve the inhibition of tumor cells on T cells, so as to restore and enhance the ability of T cells to attack tumors. These inhibitors have become an important part of the treatment of many cancers, including melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and head and neck squamous cell carcinoma (HNSCC).

High Purity

SDS-PAGE (PDCD1-28H).jpg

Fig1. SDS-PAGE (NME1-5925H)

High Bioactivity

Activity Data (PDCD1-057H).jpg

Fig2. Activity Data (PDCD1-057H)

Case Study 1: Christina Martins, 2024

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer. Inhibitors targeting the programmed cell death 1 (PD-1) immune checkpoint have improved MCC patient outcomes by boosting antitumor T cell immunity. Here, the researchers identify PD-1 as a growth-promoting receptor intrinsic to MCC cells. In human MCC lines and clinical tumors, RT-PCR-based sequencing, immunoblotting, flow cytometry, and immunofluorescence analyses demonstrated PD-1 gene and protein expression by MCC cells. MCC-PD-1 ligation enhanced, and its inhibition or silencing suppressed, in vitro proliferation and in vivo tumor xenograft growth. Consistently, MCC-PD-1 binding to PD-L1 or PD-L2 induced, while antibody-mediated PD-1 blockade inhibited, protumorigenic mTOR signaling, mitochondrial (mt) respiration, and ROS generation. Last, pharmacologic inhibition of mTOR or mtROS reversed MCC-PD-1:PD-L1-dependent proliferation and synergized with PD-1 checkpoint blockade in suppressing tumorigenesis.

Representative flow cytometric analysis of PD-1 surface protein.jpg

Fig1. Representative flow cytometric analysis of PD-1 surface protein.

Tumor growth kinetics (means ± SEM) of MKL-2 or WaGa cells grafted to NSG mice.jpg

Fig2. Tumor growth kinetics (means ± SEM) of MKL-2 or WaGa cells grafted to NSG mice.

Case Study 2: Tao Jiang, 2024

Apoptosis triggers immunoregulation to prevent and suppress inflammation and autoimmunity. However, the mechanism by which apoptotic cells modulate immune responses remains largely elusive. In the context of allogeneic mesenchymal stem cells (MSCs) transplantation, long-term immunoregulation is observed in the host despite the short survive of the injected MSCs. In this study, utilizing a mouse model of acute lung injury (ALI), the researchers demonstrate that apoptotic bodies (ABs) released by transplanted human umbilical cord MSCs (UC-MSCs) convert the macrophages from a pro-inflammatory to an anti-inflammatory state, thereby ameliorating the disease. Mechanistically, they identify the expression of programmed cell death 1 ligand 1 (PDL1) on the membrane of UC-MSCs-derived ABs, which interacts with programmed cell death protein 1 (PD1) on host macrophages. This interaction leads to the reprogramming of macrophage metabolism, shifting from glycolysis to mitochondrial oxidative phosphorylation via the Erk-dependent pathway in ALI. Importantly, we have reproduced the PDL1-PD1 effects of ABs on metabolic switch using alveolar macrophages from patients with ALI.

The expressions of PD1 and PDL1 were assessed by western blot analysis.jpg

Fig3. The expressions of PD1 and PDL1 were assessed by western blot analysis.

Line graph from seahorse analysis assessed in BMDMs.jpg

Fig4. Line graph showing extra-cellular acidification rate (ECAR) from seahorse analysis assessed in BMDMs.

PDCD1 involved in several pathways and played different roles in them. We selected most pathways PDCD1 participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)MHC1UXA2;CLDNJ;HLA-F;CDH2;SDC2;BF1;ITGA8;NLGN3;PRPSAP2
T cell receptor signaling pathwayMUC1;CD3D;PPP3CA;CD40LG;SLA1;FOS;KRAS;MAPK12;PTPN6

PDCD1 has several biochemical functions, for example, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD1 itself. We selected most functions PDCD1 had, and list some proteins which have the same functions with PDCD1. You can find most of the proteins on our site.

Function Related Protein
protein bindingXCL2;PPP1R11;BOP1;THBS1;C1orf189;FZD3;MIS12;PSMD14;POMP
signal transducer activitySLC44A2;GRM6B;CHRM5B;TAS2R109;MAPKAPK5;MTNR1BB;GPR25;LPAR6A;FAM126A

PDCD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD1.

CD274; PTPN6; PTPN11; AGO1

Research Area

Related articles

Zamani, MR; Asbagh, FA; et al. Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 32:103-106(2015).
Kenefeck, R; Wang, CJ; et al. Follicular helper T cell signature in type 1 diabetes. JOURNAL OF CLINICAL INVESTIGATION 125:292-303(2015).
  • Q&As
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Q&As (14)

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What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 07/31/2022

PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 11/09/2021

PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

What role does PDCD1 play in the development of immune tolerance? 10/15/2021

PDCD1 helps develop immune tolerance, preventing overactive immune responses.

How does PDCD1 influence the balance between immune activation and autoimmunity? 05/23/2021

PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 08/13/2020

PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

How does PDCD1 influence the balance between immune activation and autoimmunity? 08/05/2020

PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 12/05/2019

PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 11/21/2019

PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 04/24/2019

PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 01/19/2019

PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

What role does PDCD1 play in the development of immune tolerance? 12/08/2018

PDCD1 helps develop immune tolerance, preventing overactive immune responses.

How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 06/24/2018

Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 06/24/2018

PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 02/06/2018

Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

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    Timely antibody validation, a valuable asset for our laboratory.

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