Active Recombinant Human PDCD1 Protein, His&Avi tagged

• Cat.No.: PDCD1-76H
• Product Overview: PD-1 dimer protein contains a PD-1 extracellular domain (UniProt# Q15116) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 25-170 aa
• Description: Human programmed cell death protein 1 (PD-1), is a Type I membrane protein and cell surface receptor on T cells and B cells and belongs to the immunoglobulin superfamily. PD-1 is also known as PDCD1, cluster of differentiation 279 (CD279), systemic lupus erythematosus susceptibility 2 (SLEB2), and systemic lupus erythematosus susceptibility (hSLE1). PD-1 contains an extracellular immunoglobulin-V-like (Ig-V-like) domain followed by a transmembrane region, and an intracellular tail. PD-1 is an immune checkpoint that binds two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 serves as an immunosuppressive ligand for PD-1 and the overexpression of PD-L1 on many tumor cells can prevent the immune system from attacking tumors. Inhibition of the interaction between PD-1 and PD-L1 can enhance antitumor activity, which has led to a new class of drugs called PD-1 inhibitors to activate the immune system and treat certain types of cancer. Although previously considered monomeric, PD-1 has been shown to have a propensity for forming homodimers and this homodimerization increases the potency of its activity. Therefore, a recombinant protein mimicking the PD-1 dimer conformation can be crucial for cancer therapeutic discovery.
• Molecular Mass: 52 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for PD-1-specific antibody and PD-L1 ligand protein binding assays. Suggested Applications: ELISA for PD-1-specific antibody and PD-L1 ligand protein binding assays. SPR & BLI for PD-1-specific antibody and PD-L1 protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.2μm filtered PBS, pH 7.4, no preservatives
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: PDCD1 programmed cell death 1 [Homo sapiens (human)]
• Official Symbol 2: PDCD1
• Synonyms 2: PDCD1; programmed cell death 1; programmed cell death protein 1; CD279; PD1; protein PD-1; PD-1; SLEB2; hPD-1; hPD-l
• Gene ID 2: 5133
• mRNA Refseq 2: NM_005018
• Protein Refseq 2: NP_005009
• MIM 2: 600244
• UniProt ID 2: Q15116