Active Recombinant Human PTPN2 Protein, His/GST-tagged

• Cat.No.: PTPN2-144H
• Product Overview: Recombinant human N-terminal His/GST-tagged TCPTP protein (1-314) was expressed in insect cells.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
• Source: Insect cell
• Species: Human
• Tag: His/GST
• Form: Lyophilized
• Bio-activity: Specific Activity: > 20 nmoles/min/μg
• Molecular Mass: 64.4 kDa
• Protein length: 1-314
• Endotoxin: <1.0 EU/μg of the protein as determined by the LAL method
• Purity: ≥75% estimated by SDS-PAGE
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: Lyophilized from sterile PBS, pH 7.4

Gene Information

• Gene Name: PTPN2 protein tyrosine phosphatase non-receptor type 2 [ Homo sapiens (human) ]
• Official Symbol: PTPN2
• Synonyms: PTPN2; protein tyrosine phosphatase non-receptor type 2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase; EC 3.1.3.48
• Gene ID: 5771
• mRNA Refseq: NM_080423
• Protein Refseq: NP_536348
• MIM: 176887
• UniProt ID: P17706