Active Recombinant Human SRC protein, GST-tagged
Cat.No. : | SRC-1100H |
Product Overview : | Recombinant Human SRC fused with GST tag at N-terminal was expressed in E. coli. |
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Description : | SRC family belongs to non-receptor tyrosine kinases. SRC was originally identified as a transforming protein of the Rous sarcoma virus (RSV) that had enzymatic ability to phosphorylate tyrosine in protein substrates. SRC is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. In addition to increasing cell proliferation, a key role of SRC in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumour progression. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 98 nmol/min/mg |
Molecular Mass : | ~83 kDa |
Purity : | >95% |
Applications : | Kinase Assay, Western Blot |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens ] |
Official Symbol : | SRC |
Synonyms : | ASV; SRC1; THC6; c-SRC; p60-Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog |
Gene ID : | 6714 |
mRNA Refseq : | NM_005417 |
Protein Refseq : | NP_005408 |
MIM : | 190090 |
UniProt ID : | P12931 |
Products Types
◆ Recombinant Protein | ||
Src-1367M | Recombinant Mus musculus Src Protein (V85-L535), His-tagged | +Inquiry |
SRC-0403H | Recombinant Human SRC Protein (G2-L536), His/Flag tagged | +Inquiry |
SRC-0402H | Recombinant Human SRC Protein (G2-L536), Tag Free | +Inquiry |
SRC-2094H | Recombinant Human SRC Protein, His (Fc)-Avi-tagged | +Inquiry |
Src-6122M | Recombinant Mouse Src Protein, Myc/DDK-tagged | +Inquiry |
◆ Native Protein | ||
SRC-29697TH | Native Human SRC | +Inquiry |
◆ Lysates | ||
SRC-585MCL | Recombinant Mouse SRC cell lysate | +Inquiry |
SRC-487HCL | Recombinant Human SRC cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionChanges in SRC expression or kinase activity can lead to drug resistance in cancer treatment.
SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.
SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.
SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.
SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.
SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.
SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.
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