SRC

  • Official Full Name

    v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

  • Overview

    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Mus musculus
  • Rhesus Macaque
  • RSV
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • Myc|DDK
  • N/A
  • N
  • FLAG
  • No tag
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SRC-533H Active Recombinant Human SRC protein, His-tagged Insect Cell His
Human SRC-1100H Active Recombinant Human SRC protein, GST-tagged E.coli GST
Human SRC-575H Active Recombinant Human SRC, GST-tagged E.coli GST
Human SRC-1358H Active Recombinant Human SRC protein, His/GST-tagged Insect Cell His/GST
Human SRC-381H Recombinant Human SRC Mammalian Cell His
Human SRC-2947H Recombinant Human SRC, GST-tagged E.coli GST
Human SRC-191H Recombinant Human SRC, GST-tagged E.coli GST
Human SRC-433H Recombinant Human SRC, GST-tagged, Active Sf9 Insect Cell GST
Human SRC-22H Recombinant Human SRC protein, His-tagged E.coli His
Human SRC-192H Recombinant Human SRC, SH3 Domain, GST-tagged E.coli GST
Human SRC-79H Recombinant Human SRC protein, Flag-tagged, Biotinylated Insect Cell Flag
Human SRC-487HCL Recombinant Human SRC cell lysate Insect Cell N/A
Human SRC-2747H Recombinant Human SRC Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SRC-1923H Recombinant Human SRC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SRC-407HFL Recombinant Full Length Human SRC Protein, C-Flag-tagged Mammalian cells Flag
Human SRC-004H Active Recombinant Human SRC Protein, GST-tagged Insect cell GST
Human SRC-1750HF Active Recombinant Full Length Human SRC Protein, GST-tagged Insect (sf21) GST
Human SRC-3525H Recombinant Human SRC protein, His-tagged E.coli His
Human SRC2592H Recombinant Human Src (255-524) Protein
Human SRC-6766HF Active Recombinant Full Length Human SRC Protein, DDK-tagged, Biotinylated Insect (sf21) DDK
Human SRC-29697TH Native Human SRC E.coli N/A
Human SRC-3526H Recombinant Human SRC protein E.coli N/A
Human SRC-10H Active Recombinant Human SRC Protein (Full Length), N-FLAG Insect Cell N-FLAG
Human SRC-6350H Recombinant Human SRC Protein (Met1-Leu536), N-His tagged E.coli N-His
Human SRC-2094H-B Recombinant Human SRC Protein Pre-coupled Magnetic Beads HEK293
Human SRC-2094H Recombinant Human SRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SRC-0402H Recombinant Human SRC Protein (G2-L536), Tag Free Insect Cell No tag
Human SRC-0403H Recombinant Human SRC Protein (G2-L536), His/Flag tagged Insect Cell His/Flag
Human SRC-0186H Recombinant Human SRC Protein (Full Length), N-His-tagged Baculovirus-Insect cells N-His
Human SRC-6351H Recombinant Human SRC Protein (Tyr187-Leu536), N-His tagged E.coli N-His
Mouse Src-593M Recombinant Mouse Rous Sarcoma Oncogene, Domain E.coli N/A
Mouse Src-99M Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain E.coli N/A
Mouse Src-907M Active Recombinant Mouse Src protein(Met1-Leu535), His&GST-tagged Insect Cells N-His&GST
Mouse SRC-585MCL Recombinant Mouse SRC cell lysate Insect Cell N/A
Mouse Src-6122M Recombinant Mouse Src Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mus musculus Src-1367M Recombinant Mus musculus Src Protein (V85-L535), His-tagged Insect Cell His
Mus musculus Src-1368M Recombinant Mus musculus Src Protein (V85-L535) Insect Cell Tag Free
Rhesus Macaque SRC-4460R Recombinant Rhesus monkey SRC Protein, His-tagged Mammalian Cell His
Rhesus Macaque SRC-4276R-B Recombinant Rhesus Macaque SRC Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SRC-4276R Recombinant Rhesus Macaque SRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
RSV Src-546R Active Recombinant RSV Src, GST-tagged Sf9 Insect Cell GST
Zebrafish SRC-1128Z Recombinant Zebrafish SRC Mammalian Cell His
Chicken SRC-7007C Recombinant Chicken SRC Mammalian Cell His
Kit-0800 c-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SRC Related Articles
  • SRC Related Gene Family
  • SRC Related Research Area
  • SRC Related Signal Pathway

SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayABL2;BADB;AKT2;SHC3;ARAF;PRKCG;CAMK2D;PIK3CA;KRAS
Rap signaling pathwayPFN3;BCAR1;RAP1GAP;ACTB;KLK1B4;PDGFD;PDGFA;FPR1;PRKCZ
Chemokine signaling pathwayCXCL14;VAV2;PRKACA;Ccl21c;MAPK1;HCK;STAT5B;AMCF-II;GNG12
EndocytosisCAV2;HRAS;EPS15;NEDD4L;RAB31;KIF5AA;ARAP3;RAB22A;PARD6A
VEGF signaling pathwayPTGS2B;SHC2;PTK2AB;RAC1;RAF1A;RAF1;PIK3R2;PPP3CB;NOS3
Focal adhesionITGB1;RAPGEF1B;ILK;CAV1;ARHGAP5;ACTB;FLT1;MAPK9;MAP2K1
Adherens junctionWASF3B;WASLB;RAC1A;FYNB;CTNNA2;AASS;PVRL3;ACTB;PVRL1
Tight junctionCASK;RAB3B;MYHC4;VMHCL;GNAI2A;JAM2A;CLDN7A;MYL2;F11R.1
Gap junctionPDGFRA;ITPR3;GJA1;MAPK7;PLCB1;DRD2A;MAP2K2;GNA15.4;GRM1
Platelet activationGP1BA;PRKG1;P2RX1;PIK3R1;RHOA;Adcy4;PPP1CC;ROCK1;ITGA2B
GABAergic synapseGABARAPL2;GNG12;SRC;GABRA4;GLS;GABRQ;GNG5;PRKACG;GABRR1
Inflammatory mediator regulation of TRP channelsITPR3;PLCB4;BDKRB1;MAPK13;CALML5;PIK3CD;ASIC3;MAPK8;HTR2B
Regulation of actin cytoskeletonFGFR3;PIK3R2;ARPC5B;FGF12;BCAR1;FGF5;PXNA;CDC42L2;FGF21
GnRH signaling pathwayCALM3B;CALM1B;MAP2K1;CDC42;CALM2;PRKCBB;MAP2K3;MAPK11;CALML3
Estrogen signaling pathwayFKBP4;CALML5;PIK3CG;PIK3CB;MAP2K1;HSP90AA1;ESR2;GNAI3;GNAI2
Prolactin signaling pathwayPPIB;PRLR;RAF1;MAPK11;KRAS;MAPK1;FOXO3;PIK3CG;SHC2
Thyroid hormone signaling pathwayMED12L;KAT2B;PRKACG;NOTCH2;HIF1A;DIO1;NCOR1;MAP2K2;SLC2A1
Oxytocin signaling pathwayOXTR;PPP3R2;RYR2;PLA2G4C;NOS3;CACNB4;CALM2;CALM1;CD38
Bacterial invasion of epithelial cellsCD2AP;VCL;SHC4;CTTN;ARPC1B;PIK3R3;ITGB1;SEPT3;SRC
Epithelial cell signaling in Helicobacter pylori infectionATP6V1B2;PAK1;MAP2K4;PTPN11;ATP6V1G3;MAPK11;CCL5;ATP6V0A1;ATP6V0C
ShigellosisIL-8;BTRC;NFKBIA;IKBKG;ABL1;ARPC5L;RIPK2;ROCK1;HCLS1
TuberculosisFCGR2B;IFNGR2;LBP;IFNA4;PLK3;MAPK3;HLA-DMA;CAMP;IFNGR1
Hepatitis BEGR3;MAPK8;NFATC2;PIK3CB;IFNA5;IFIH1;EGR2;PIK3CG;CXCL8
Viral carcinogenesisCCNE2;GSN;TBPL2;HDAC10;ATP6V0D2;HIST1H2BQ;GTF2H2;IL6ST;KRAS
Proteoglycans in cancerIGF1R;SOS1;NRAS;WNT8B;CD44;CAV3;MSN;FZD3;ROCK1
Bladder cancerTP53;SRC;MAPK1;THBS1;FGFR3;HBEGF;EGF;MMP2;TRP53

SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX3X;CAMK4;ALPK2;PIM3;MAP2K4A;STK38;CSNK2A2A;TLK1A;LMTK2
SH2 domain bindingKHDRBS2;INPPL1;SKAP1;LAT2;PTK2;LAX1;LILRB1;SQSTM1;NLK
SH3/SH2 adaptor activityGRB2;PTPN11;GRB7;SOCS2;KHDRBS1;CD28;SKAP1;CRK;BLNK
enzyme bindingPDCD2;USP22;HIST1H2AK;IQCB1;HNRNPUL1;HINFP;PLAUR;TAF10;YES1
ephrin receptor bindingEFNB2B;EPHA4;EPHA7;EFNA1;EFNA3B;PIK3CG;SHC1;EFNA1B;EFNA5
growth factor receptor bindingSRC;SLC9A3R1;FYN;APP
heme bindingCYP21A1;NOX4;CYP4A12A;CYP19A1A;MPO;CYP4B1;HBAA;PTGS2;HBG1
hormone receptor bindingTNK2B;SRC;JAK2B;JAK2A;JAK3;TNK2;TNK1
integrin bindingECM2;ANXA7;ITGA6;WISP3;ICAM5;COL4A3;ADAM2;CALR;ADAM15
ion channel bindingKCNE2;AKAP6;FKBP1B;FXYD1;SCN5A;PIRT;KCNE1L;GRINA;RIMS1
kinase activityPRKRIRA;SBK1;CDKN1D;EPHB4A;PHKG1B;ZNF143B;NEK4;PRKG1A;BCR
kinase bindingLDHA;WWC1;DLG1;TAX1BP1;MOBKL1A;PARK2;PPP1R9B;PRKCD;CEBPB
non-membrane spanning protein tyrosine kinase activityTEC;MELK;TNK1;TNK2B;PRKCD;JAK2A;HCK;FYN;PTK2AA
phosphoprotein bindingRRAGA;URI1;FKBP4;YWHAE;MS4A2;MID1;TBK1;SAG;RB1
protein bindingHSPG2;ZNF821;ZFYVE19;GCM1;MAP6;ZNF41;CNTNAP2;STAG2;GDAP2
protein kinase activityAVP;SBK3;MAP3K10;AURKC;PTK2AB;EIF2AK2;GRK7B;SOX9;FYNA
protein tyrosine kinase activityEPHB2;FGFR1B;ERBB4A;ZAP70;MAP2K1;MAP2K4;LYN;MATK;JAK2B
receptor bindingSMARCD3;MATK;CCL2;NCR3;RND1;Ren1;MCHR1;RAB8B;SNX17
scaffold protein bindingADCY6;CHRNA7;PDE4D;KCNH2;SHANK3;KRT5;IKBKB;NLRP1;MDM2

SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.

PTPN1; PTK2

Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).
  • Q&As
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Q&As (7)

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How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

Customer Reviews (3)

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01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

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