SRC Protein

SRC

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SRC

Official Full Name v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Background This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Synonyms SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Mus musculus
    • Rhesus Macaque
    • RSV
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Insect cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • BTN
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • His/Flag
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • No tag
    • Tag Free
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SRC-533H Active Recombinant Human SRC protein, His-tagged Insect Cell His Inquiry
    Human SRC-1100H Active Recombinant Human SRC protein, GST-tagged E.coli GST Inquiry
    Human SRC-1358H Active Recombinant Human SRC protein, His/GST-tagged Insect Cell His/GST Inquiry
    Human SRC-575H Active Recombinant Human SRC, GST-tagged E.coli GST Inquiry
    RSV Src-546R Active Recombinant RSV Src, GST-tagged Sf9 Insect Cell GST Inquiry
    Human SRC-191H Recombinant Human SRC, GST-tagged E.coli GST Inquiry
    Human SRC-192H Recombinant Human SRC, SH3 Domain, GST-tagged E.coli GST Inquiry
    Human SRC-22H Recombinant Human SRC protein, His-tagged E.coli His Inquiry
    Human SRC-2947H Recombinant Human SRC, GST-tagged E.coli GST Inquiry
    Human SRC-381H Recombinant Human SRC Mammalian Cell His Inquiry
    Human SRC-433H Recombinant Human SRC, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Human SRC-79H Recombinant Human SRC protein, Flag-tagged, Biotinylated Insect Cell Flag Inquiry
    Mouse Src-593M Recombinant Mouse Rous Sarcoma Oncogene, Domain E.coli N/A Inquiry
    Mouse Src-907M Recombinant Mouse Src, His & GST tagged Insect Cell His/GST Inquiry
    Mouse Src-99M Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain E.coli N/A Inquiry
    Rhesus Macaque SRC-4460R Recombinant Rhesus monkey SRC Protein, His-tagged Mammalian Cell His Inquiry
    Chicken SRC-7007C Recombinant Chicken SRC Mammalian Cell His Inquiry
    Zebrafish SRC-1128Z Recombinant Zebrafish SRC Mammalian Cell His Inquiry
    Human SRC-487HCL Recombinant Human SRC cell lysate Insect Cell N/A Inquiry
    Mouse SRC-585MCL Recombinant Mouse SRC cell lysate Insect Cell N/A Inquiry
    Human SRC-004H Recombinant Human SRC Protein, GST-tagged Insect cell GST Inquiry
    Human SRC-0402H Recombinant Human SRC Protein (G2-L536), Tag Free Insect Cell No tag Inquiry
    Human SRC-0403H Recombinant Human SRC Protein (G2-L536), His/Flag tagged Insect Cell His/Flag Inquiry
    Mus musculus Src-1367M Recombinant Mus musculus Src Protein (V85-L535), His-tagged Insect Cell His Inquiry
    Mus musculus Src-1368M Recombinant Mus musculus Src Protein (V85-L535) Insect Cell Tag Free Inquiry
    Human SRC-1750HF Recombinant Full Length Human SRC Protein, GST-tagged Insect (sf21) GST Inquiry
    Human SRC-2094H Recombinant Human SRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human SRC-3525H Recombinant Human SRC protein, His-tagged E.coli His Inquiry
    Human SRC-3526H Recombinant Human SRC protein E.coli N/A Inquiry
    Human SRC-407HFL Recombinant Full Length Human SRC Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human SRC-4143H Recombinant Human SRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Rhesus Macaque SRC-4276R Recombinant Rhesus Macaque SRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human SRC-6766HF Recombinant Full Length Human SRC Protein, BTN-tagged Insect (sf21) BTN Inquiry
    Human SRC-1923H Recombinant Human SRC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human SRC-2747H Recombinant Human SRC Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human SRC-29697TH Native Human SRC E.coli N/A Inquiry
    Mouse Src-6122M Recombinant Mouse Src Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Kit-0800 c-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A Inquiry

    SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway CAMK2B; PIK3CD; NCK2B; SHC4; MAPK1; CAMK2D; PAK6B; PAK4; CDKN1BB; MAP2K2
    Rap signaling pathway PARD6A; LCP2; Pdgfa&Pdgfb; PIK3CD; FGF3; Itgam&Itgb2; THBS1; BCAR1; MLLT4; RHOA
    Chemokine signaling pathway Ccl21c; CCL21; FOXO3; GNG2; IKBKB; PIK3CB; GRK7; CXCR4; CCL11; AMCF-II
    Endocytosis ARRB2B; CHMP6B; VPS25; IQSEC1; SNX1; PARD6A; CBLB; VPS26BL; ARRB2; GIT1
    VEGF signaling pathway PXNA; SPHK2; PIK3CB; HSPB1; BAD; PRKCBA; CDC42; RAC1; HRAS; RAC1B
    Focal adhesion ACTN3; PAK4; AKT3A; MAPK8B; LAMB3; CAV1; TNN; ACTN3A; ITGB1B.2; IGF1
    Adherens junction NLK1; PTPRF; RHOAC; ACTB2; CSNK2A1; MLLT4; RAC3; FARP2; LMO7A; PTPRJA
    Tight junction MLLT4; MPDZ; PARD6GA; CLDNH; CLDNA; MYLPFA; MYH1; MYLPFB; MPP5; CSDA
    Gap junction TUBA8L2; GNAI2; GJA1; PRKCA; MAP2K5; SRC; TUBA1A; HRAS; PDGFD; MAPK3
    Platelet activation PRKACB; APBB1IP; MAPK1; PLCB1; AKT1; TBXA2R; ARHGAP35; PRKACG; MAPK12; AKT2
    GABAergic synapse PRKACG; SLC12A5; GABRG2; GNG5; GABRB3; GABRD; GNB2; GABRG1; GNB4; PRKCB
    Inflammatory mediator regulation of TRP channels PLA2G4A; PRKCA; PIK3R1; Adcy4; PTGER2; PLCB3; CYP2C55; CALM4; PRKACG; TRPV1
    Regulation of actin cytoskeleton SSH3; ITGB7; ABI2A; F2R; LIMK1A; ACTB; VCL; ACTB2; PIP5K1AA; PIP4K2B
    GnRH signaling pathway MAPK12; RAF1; ITPR3; GNRH1; MAP3K4; GRB2; CAMK2D; CDC42L2; EGFRA; CALM3A
    Estrogen signaling pathway SP1; GNAI2; SRC; PIK3R5; KRAS; HSP90AB1; SHC2; KCNJ3; PRKCD; ATF4
    Prolactin signaling pathway NFKB1; PIK3CG; SLC2A2; SOCS1; SIRPA; STAT3; PRP2; SHC1; MAPK9; TH
    Thyroid hormone signaling pathway MED12; ATP1B2; SLC16A10; PRKCB; EP300; ATP1A2; HDAC2; PLCB2; MAP2K2; PLCD4
    Oxytocin signaling pathway NFATC3; PRKCA; PRKACA; CACNG7; CALML5; PIK3R1; CCND1; CACNG4; PRKCG; CAMK1G
    Bacterial invasion of epithelial cells CBLC; CTTN; VCL; PIK3CD; CTNNA2; SHC3; CLTA; CRK; ARPC3; ARPC2
    Epithelial cell signaling in Helicobacter pylori infection LYN; PTPN11; ATP6V1H; CDC42; ATP6V1C2; ATP6V1B1; CXCL1; ATP6V1B2; JAM2; IKBKB
    Shigellosis MAPK3; MAPK8; MAPK13; U2AF1L4; FBXW11; ELMO2; ROCK2; ACTB; RAC1; PFN4
    Tuberculosis MRC1; LAMP1; FCGR1; HLA-DMB; CYCS; CLEC4E; CD209C; MAPK11; SRC; IFNA1
    Hepatitis B PIK3CD; MAPK10; HBXIP; Ifna11; OSTN; PIK3R5; ATF4; MYD88; STAT2; BCL2
    Viral carcinogenesis ATF4; TBPL1; CCNA1; HIST2H2BB; KRAS; HDAC9; HLA-A; SKP2; PRKACB; IL6ST
    Proteoglycans in cancer RPS6; PIK3R5; ITGA5; SLC9A1; ITPR3; MAP2K1; CAMK2A; CBLC; GPC1; MMP2
    Bladder cancer MMP1; MAP2K1; CDKN2A; ERBB2; UPK3A; CCND1; BRAF; MMP2; THBS1; MDM2

    SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CHST13; NEK6; HSP90AA1; NTRK3; PIKFYVE; FGFR4; UBE2N; BMPR1BB; ATAD1; ATP2C1
    SH2 domain binding TRPV4; NUP62; IRS1; SIT1; PAG1; LAT2; LILRB1; INPPL1; MS4A2; SQSTM1
    SH3/SH2 adaptor activity CD28; STAP1; SH3BGRL; SH3BGR; STAM; HSH2D; SKAP1; SKAP2; CRK; LAT
    enzyme binding LDB2; BTG1; HIST1H2AL; CBX4; CA; CYB5A; PRKDC; HIST1H2AI; FOXO4; EIF2AK3
    ephrin receptor binding CBL; SRC; Anks1; EFNA3; SDCBP; EFNA5; PIK3CG; EFNB3B; EFNA3B; CDK5R1
    growth factor receptor binding SRC; SLC9A3R1; FYN; APP
    heme binding CYP7A1; CYP2X7; CYP8B1; HBA2; HBBE3; CYGB1; CYP2A6; CYP4B1; CYP3C1; STC2
    hormone receptor binding TNK1; SRC; JAK3; TNK2B; JAK2A; JAK2B; TNK2
    integrin binding L1CAM; VTN; CXADR; LAMB2; ADAM23; CYR61; PXN; ADAM15; TSPAN4; ITGB1BP1
    ion channel binding EPN1; CAV3; SCN5A; ACTN1; HSP90AB1; PKP2; PHPT1; PIRT; FKBP1B; FGF13
    kinase activity ZNF143B; PRKAB1A; KITB; INSRA; PIP5K1AA; BSK146; MARCKSB; NEK4; PTK2BB; EPHB4B
    kinase binding DUSP12; CTNNB1; CDC6; RPS3; BARD1; PRPSAP1; PRKAA1; PRKCD; HPCA; JAKMIP2
    non-membrane spanning protein tyrosine kinase activity SRMS; FRK; LCK; DYRK1A; BMX; JAK1; PTK2; SRC; CSK; FYNB
    phosphoprotein binding PAFAH1B1; PKD2; RB1; SERPINB1A; CSNK1D; LYN; YWHAB; MID1; PITX2; SNCA
    protein binding PCBD1; YES1; ACBD3; POLR2J; VIM; IGFBP5; CCKBR; MTMR14; GPSM3; NGB
    protein kinase activity PIK3CG; PAK1; CDK11B; OXSR1B; PHKG1B; PRKAA1; SNRKB; NPRL2; CLK2A; PRKCI
    protein tyrosine kinase activity SRC; MAP3K9; EPHB2; YES1; PTK2BB; FGFR1OP; MAP3K11; ERBB4A; MAP2K2; CLK4
    receptor binding BAAT; FGF13B; ANG; F2RL1; SLC9A3R2; NRG2A; ARPP19; YES1; INSL4; ACOT2
    scaffold protein binding SRC; NLGN4X; CHRNA7; KCNH2; MAPK3; MAP2K2; SHANK3; KCNQ1; IKBKB; NLGN1

    SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.

    PTPN1; PTK2

    Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
    He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).

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