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  • Official Full Name
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • Background
  • This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2
Cat.#:SRC-2747HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SRC Protein, MYC/DDK-tagged
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Cat.#:SRC-1100HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, GST-tagged
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Cat.#:SRC-1358HTag:His/GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His/GST-tagged
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Cat.#:SRC-192HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, SH3 Domain, GST-tagged
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Cat.#:SRC-22HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
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Cat.#:SRC-2947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-381HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SRC
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Cat.#:SRC-533HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
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Cat.#:SRC-575HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-79HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human SRC protein, Flag-tagged, Biotinylated
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Cat.#:Src-907MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Src, His & GST tagged
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Cat.#:SRC-4460RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SRC Protein, His-tagged
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Cat.#:SRC-7007CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SRC
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Cat.#:SRC-1128ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SRC
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Cat.#:Src-546RTag:GST
Source (Host):Sf 9 insect cellsSpecies:RSV
Product nameRecombinant RSV Src, GST-tagged
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Cat.#:SRC-191HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SRC, GST-tagged, Active
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Cat.#:Src-593MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, Domain
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Cat.#:Src-99MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, SH3 Domain
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Cat.#:SRC-29697THTag:
Source (Host):E. coliSpecies:Human
Product nameNative Human SRC
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Cat.#:SRC-487HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SRC cell lysate
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Cat.#:SRC-585MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SRC cell lysate
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Cat.#:Kit-0800Tag:
Source (Host):Species:
Product namec-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit
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Involved Pathway

SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PAK6B; RAF1A; MYCB; PIK3CA; NCK2B; PTK2; PIK3R3; RPS6KB2; MAP2K7; SRC
Rap signaling pathway
NRAS; PDGFRB; GNAI3; KIT; INSR; PRKCZ; P2RY1; RAC3; FGF14; NGFR
Chemokine signaling pathway
CCL4; GRK7; CXCL8; RAF1; CX3CR1; Ccl21a; CXCL5; AKT1; CCR6; GNAI3
Endocytosis
SRC; PARD3; ADRB2A; RAB35B; FAM21C; RAB10; VPS4A; EGFRA; ARF6; FOLR3
VEGF signaling pathway
PLA2G4A; PLA2G4D; HSPB1; PRKCA; MAPK14A; PTK2; PPP3CCA; SRC; AKT2L; AKT2
Focal adhesion
LAMA3; RAC3; CAV2; ITGA4; EGFRA; MYL7; VCLA; PIK3R5; BAD; Itga10&Itgb1
Adherens junction
ACTN3; LEF1; WASLB; WAS; PVRL1B; ACTB; FYNA; WASF1; SSX2IPA; WASB
Tight junction
RHOA; CLDN11B; MYH4; ACTN3B; CLDNH; PARD3; CLDNG; MPP5; RHOAA; RAB3B
Gap junction
TUBB2A; GNAI2; PLCB4; GUCY1B3; HTR2B; TUBA4L; PRKG1; TUBB6; MAPK1; RAF1
Platelet activation
TBXA2R; GNAS; PLA2G4D; GP1BB; MAPK12; PPP1R12A; PLCG2; PIK3CA; PPP1CB; PIK3CB
GABAergic synapse
SLC38A2; PRKCA; GABRG2; GABRB1; SLC38A5; GNB4; GNB2; GNAO1; GABRB3; GABARAP
Inflammatory mediator regulation of TRP channels
PPP1CC; PIK3R1; CYP2C70; CALML3; PLA2G4F; PLCG2; ALOX12E; MAPK9; PRKACA; CYP4A12A
Regulation of actin cytoskeleton
FGF9; SCINLA; ITGB2; ARHGAP35; MYL9A; MSNB; PIP5KL1; NCKAP1L; HRASB; ENAH
GnRH signaling pathway
PLCB4; MMP14; CALM2A; MAP2K2; GNA11A; CALM2; RAF1; GNRHR; PRKCBA; MAPK8A
Estrogen signaling pathway
PRKCD; CALM3; HSPA8; PIK3R1; GRB2; PRKACB; SHC2; PIK3R2; CALM2; FKBP5
Prolactin signaling pathway
SHC1; SHC4; IRF1; STAT3; SIRPA; INS1; GRB2; RELA; PIK3R1; SOCS3
Thyroid hormone signaling pathway
THRB; SLC9A1; FOXO1; ACTB; PFKFB2; MDM2; MED14; AKT2; DIO1; BAD
Oxytocin signaling pathway
NFATC1; MAP2K1; KCNJ14; ACTB; PPP3CB; NRAS; MAPK7; PRKCB; CACNA2D1; CACNA2D2
Bacterial invasion of epithelial cells
WASL; CTNNA2; VCL; PIK3R2; ACTG1; CDC42; ARPC3; PIK3R5; WASF1; SEPT3
Epithelial cell signaling in Helicobacter pylori infection
ATP6AP1; PAK1; TCIRG1; MAPK9; SRC; IL-8; PLCG2; MAP3K14; ATP6V0A1; ATP6V1B1
Shigellosis
HCLS1; MAPK3; RELA; CTTN; IKBKB; ATG5; NFKB1; ELMO1; CDC42; DIAPH1
Tuberculosis
FCGR2B; PMAP-36; IFNA4; CARD9; HLA-DRB3; TGFB3; VDR; MAPK11; IL18; RELA
Hepatitis B
IKBKB; FOS; CXCL8; MAP2K1; IFIH1; TLR2; FADD; IFNA2; PIK3CA; IFN-a
Viral carcinogenesis
PSMC1; H2-Q10; MAPK3; GTF2H1; ACTN2; DLG1; HIST1H4H; NFKB1; BAD; CASP8
Proteoglycans in cancer
WNT9A; FZD1; PRKACB; CD44; PRKACG; RRAS; SOS1; CAV3; HIF1A; IGF1R
Bladder cancer
CXCL8; E2F1; MAP2K2; MAPK3; MMP1A; CDKN2A; MYC; MMP2; THBS1; CCND1

Protein Function

SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RIPK2; STK10; CLK2B; DHX30; DDX6; MATK; RYK; MCM3L; CKBB; PBK
Function SH2 domain binding
Related Protein CRK; SHCBP1; SH3PXD2B; PAG1; ARHGAP5; AFAP1L2; CTR9; PTK2; IRS1; SYNGR3
Function SH3/SH2 adaptor activity
Related Protein LAT; SKAP1; SHB; SH2D2A; RUSC1; ARHGAP1; LASP1; STAP1; IRS4; SH3BP2
Function enzyme binding
Related Protein GSTM2; ESR1; CBS; HMOX1; CD4; SUPT5H; LAMP1; KDM4C; HMGA1; CASP2
Function ephrin receptor binding
Related Protein EFNA2A; EFNA1B; EFNA3B; EFNA4; EFNB2; EFNA2; EPHA4; SRC; EFNA5B; SDCBP
Function growth factor receptor binding
Related Protein SLC9A3R1; SRC; APP; FYN
Function heme binding
Related Protein MFSD7C; SDHD; HBAD; CYP2J5; HBG1; HBBE1.1; PTGS2A; CYP19A1A; CYP2P9; CYP2AA7
Function hormone receptor binding
Related Protein TNK2; TNK2B; JAK2B; SRC; JAK3; TNK1; JAK2A
Function integrin binding
Related Protein WISP1; CTGFB; TSPAN4; ADAMTS5; MMP14; COL4A3; ADAMTS13; ADAM25; FBN1; NISCH
Function ion channel binding
Related Protein RIMS1; SUMO1; KCNIP2; PKD1; PACS1; AP2M1; S100A10; PDE4D; SCN5A; FKBP1B
Function kinase activity
Related Protein MAPKAPK2A; PRKRIRA; MKNK2A; STK35L; PDXKB; ALPK2; PRKAR2AA; CCNE1; CAMK1GB; MTOR
Function kinase binding
Related Protein CEBPB; PPP2R5A; DGKQ; NTRK1; CAB39; PER3; BCL10; TNFAIP3; TOLLIP; PFKFB1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein SYK; CSK; FYNB; ABL2; PKDCC; JAK3; YRK; ZAP70; MATK; PTK2BB
Function phosphoprotein binding
Related Protein FKBP4; SFN; CBX4; THRAP3; APTX; DPYSL3; YWHAE; SERPINB1A; SAG; PKD2
Function protein binding
Related Protein ITPKB; CTPS2; LRCH1; NEK9; HOXA9; TCHP; ITM2C; TBATA; TARS; VDAC1
Function protein kinase activity
Related Protein SGK2B; CCND1; NEK12; PAK2B; PRKACBA; INSRB; RAF1; MOK; TSSK1; MAP3K5
Function protein tyrosine kinase activity
Related Protein LTK; TESK1; MAP2K3; INSRA; TTN; KITB; DYRK1B; PTK2B; IGF1RB; PTK2AB
Function receptor binding
Related Protein AGRP; NRXN1; CD58; FGF12B; NPPB; CADM2A; P2RX4; GSTK1; FGF6B; HFE
Function scaffold protein binding
Related Protein KRT8; NLGN4Y; DSP; ADCY6; SRC; TREM1; CAV2; ATP2B4; SHANK3; P2RY1

Interacting Protein

SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.
PTPN1; PTK2

SRC Related Articles

Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).

SRC Related Gene Family

GPCRs TGF