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  • Official Full Name
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • Background
  • This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2
Cat.#:SRC-2747HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SRC Protein, MYC/DDK-tagged
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Cat.#:SRC-1100HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, GST-tagged
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Cat.#:SRC-1358HTag:His/GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His/GST-tagged
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Cat.#:SRC-192HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, SH3 Domain, GST-tagged
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Cat.#:SRC-22HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
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Cat.#:SRC-2947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-381HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SRC
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Cat.#:SRC-533HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
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Cat.#:SRC-575HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-79HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human SRC protein, Flag-tagged, Biotinylated
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Cat.#:Src-907MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Src, His & GST tagged
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Cat.#:SRC-4460RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SRC Protein, His-tagged
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Cat.#:SRC-7007CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SRC
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Cat.#:SRC-1128ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SRC
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Cat.#:Src-546RTag:GST
Source (Host):Sf 9 insect cellsSpecies:RSV
Product nameRecombinant RSV Src, GST-tagged
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Cat.#:SRC-191HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SRC, GST-tagged, Active
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Cat.#:Src-593MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, Domain
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Cat.#:Src-99MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, SH3 Domain
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Cat.#:SRC-29697THTag:
Source (Host):E. coliSpecies:Human
Product nameNative Human SRC
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Cat.#:SRC-487HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SRC cell lysate
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Cat.#:SRC-585MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SRC cell lysate
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Cat.#:Kit-0800Tag:
Source (Host):Species:
Product namec-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit
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Involved Pathway

SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PTK2AB; MAPK8A; GSK3AA; PRKCA; CAMK2G; SHC4; ERBB3A; ARAF; ERBB4; MAP2K2B
Rap signaling pathway
GNAS; P2RY1; SIPA1L1; FGF22; PGF; ITGAM; VASP; NGF; FIGF; GRIN2B
Chemokine signaling pathway
PTK2B; CXCR4; GNB1; PLCB1; CCR5; VAV2; CCL8; WASL; IKBKB; STAT2
Endocytosis
WASLA; PSD; CBL; ARF6A; DNM1B; SMAP2; CCDC53; SH3GLB1B; RAB11A; RAB11FIP2
VEGF signaling pathway
PIK3R3B; MAPK11; RAC1A; RAC2; CDC42; MAP2K2B; MAPK3; RAF1A; MAP2K2A; PTK2AB
Focal adhesion
RAC2; MYLPFB; VAV2; MYL9B; AKT2; MYL7; LAMB4; PDGFRB; MET; ITGB5
Adherens junction
FARP2; RAC1; ACTB1; MAP3K7; WASB; NLK2; LMO7; RHOAA; CTNNA1; RAC3A
Tight junction
MPP5; CLDN11A; JAM2A; PPP2R2D; ACTN4; CLDN1; SHROOM2; MYLPFA; EPB41L3; AKT2
Gap junction
GNA11A; TUBB2A; GRB2; GNA15.4; MAP2K1; DRD1A; RAF1B; HTR2B; PRKCG; TUBB5
Platelet activation
PPP1R12A; PIK3CA; SYK; GNAI3; PLA2G4D; PIK3R1; PRKCI; ITGA2B; APBB1IP; MYL12A
GABAergic synapse
GABRG2; GABRA1; SLC38A5; GAD1; SLC6A1; GAD2; GNB1; GABARAPL2; GNB3; GABARAPL1
Inflammatory mediator regulation of TRP channels
CYP2C55; MAPK9; IL1B; NTRK1; PLCB2; CALM3; PPP1CC; PRKCD; PRKCQ; CAMK2G
Regulation of actin cytoskeleton
HRASA; ARHGEF1; FGF8A; PIP5K1BA; PDGFA; ITGA1; SSH2; CYFIP2; GSN; ITGB7
GnRH signaling pathway
CALML3; CALM3; GNA11B; MAP2K6; CALM3B; GNRHR2; CAMK2B; CAMK2D; MAP2K4; MAPK12B
Estrogen signaling pathway
HSPA1L; ITPR3; KCNJ3; CALML3; PIK3R1; OPRM1; NOS3; CREB3L3; KCNJ6; PIK3CG
Prolactin signaling pathway
MAPK10; STAT1; TNFRSF11A; RAF1; PRP2; INS1; PIK3CD; PIK3R5; CSN2; AKT1
Thyroid hormone signaling pathway
NCOR1; PIK3CD; MAP2K2; PRKCB; THRB; FOXO1; HIF1A; MTOR; CCND1; PLCD4
Oxytocin signaling pathway
PRKAG2; HRAS; PPP1R12B; MAPK3; PRKAG3; FOS; CAMK2G; GNAI3; GNAI1; PLCB3
Bacterial invasion of epithelial cells
SEPT3; SHC4; SEPT12; ELMO3; CD2AP; RAC1; CTNNA1; SEPT9; CBLC; CAV2
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1A; MAPK13; ATP6V1G1; MAP2K4; ATP6V0A1; ATP6V1H; PAK1; IL-8; ATP6V0D1; SRC
Shigellosis
ELMO3; MAPK3; ITGB1; HCLS1; ELMO2; MAPK1; CDC42; MAPK12; BTRC; UBE2D2
Tuberculosis
FCGR2B; NFYC; BAD; AKT1; RAB7; FCGR3B; FCGR3A; IFNA4; HLA-DRB5; ATP6AP1
Hepatitis B
IFNA5; STAT5B; NFATC3; IFN-a; DDX58; GRB2; MAPK10; TRP53; STAT5A; KRAS
Viral carcinogenesis
HLA-E; CCNA2; NFKBIA; HIST1H4H; VAC14; GTF2A2; VDAC3; EP300; PRKACG; HDAC4
Proteoglycans in cancer
PXN; MTOR; PPP1R12C; ESR1; RHOA; SLC9A1; WNT9A; CBLB; FZD3; HCLS1
Bladder cancer
NRAS; RB1; MYC; RPS6KA5; SRC; TRP53; TYMP; MAP2K1; CDH1; MDM2

Protein Function

SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CKMT1A; KIF12; GMPS; ABCA6; EK1; ATP2A1; PTK2AB; PRPS1L1; RUVBL2; LIMK1
Function SH2 domain binding
Related Protein DLC1; ARHGAP5; NLK; NUP62; AFAP1L2; CTR9; LCK; PTK2; SKAP1; LAT2
Function SH3/SH2 adaptor activity
Related Protein CHN1; SOCS2; GRB14; CD28; SH2D2A; GRAP; EPS8; CHN2; GRB7; ARHGAP1
Function enzyme binding
Related Protein PRKCA; BLZF1; TUT1; ECM1; RFC5; PARK2; PIAS3; CYP2E1; CD40; SLC12A3
Function ephrin receptor binding
Related Protein Anks1; CBL; EFNA5; EFNB2B; EFNA2; EFNA3; EFNB3B; EFNA5B; EFNA1A; SDCBP
Function growth factor receptor binding
Related Protein FYN; SLC9A3R1; APP; SRC
Function heme binding
Related Protein HBE1; CYP1A1; CYP2K22; CYP2J5; CYP2A4; CYP17A2; SDHC; HBD; TDO2A; HBA2
Function hormone receptor binding
Related Protein JAK3; JAK2B; SRC; JAK2A; TNK2; TNK1; TNK2B
Function integrin binding
Related Protein CIB2; FN1A; EDIL3; LAMB2; THBS1; TSPAN8; WISP1B; PPAP2B; ADAM2; COL3A1
Function ion channel binding
Related Protein SNTA1; PPP1R9B; PKP2; KCNIP1; TRPC1; HTT; ACTN2; FKBP1B; RYR2; FYN
Function kinase activity
Related Protein RAF1A; MAP2K2A; MAPK8B; CSNK2A2A; GRK1B; PRPS1; CAMK2B1; NIM1; ADKA; AKT1
Function kinase binding
Related Protein CDC6; PARK7; PFKFB1; BTG1; PTPN22; TRADD; PRPSAP1; CAB39; PFKM; CHP1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein TEC; MATK; YES1; PTK2AB; CLK1; BLK; ITK; FYNA; JAK2; PTK2AA
Function phosphoprotein binding
Related Protein SAG; PITX2; YWHAB; TBL2; SFN; CACNB2; DPYS; PLAT; LYN; RRAGA
Function protein binding
Related Protein GATAD2A; C14orf135; HDDC3; C2orf51; AKR7A3; HFE; PSMB1; EP400; TDO2; CXXC11
Function protein kinase activity
Related Protein TRIOA; IKBKAP; cka1; MAP4K6; BMPR2A; MAPKAPK2; PRKCDA; RPS6KA5; EEF2K; HIPK3B
Function protein tyrosine kinase activity
Related Protein DSTYK; MAP2K2; KIT; ERBB3A; SRMS; MAP2K3; MAP2K4; CSK; ZNF143B; MAP2K1
Function receptor binding
Related Protein CTNND1; TNFSF13B; FGF8A; DDX54; LTB; FGF1A; APOL2; HAO1; FLT3LG; AMH
Function scaffold protein binding
Related Protein NOS1; KRT8; CAV2; ADCY6; NLGN4X; NCK2; SRC; LRP4; CHRNA7; KRT15

Interacting Protein

SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.
PTPN1; PTK2

SRC Related Articles

Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).

SRC Related Gene Family

GPCRs TGF