SRC Protein


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Official Full Name v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Background This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Synonyms SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • RSV
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SRC-004H Recombinant Human SRC Protein, GST-tagged Insect cell GST
    Human SRC-3525H Recombinant Human SRC protein, His-tagged E.coli His
    Human SRC-3526H Recombinant Human SRC protein E.coli N/A
    Human SRC-1100H Recombinant Human SRC protein, GST-tagged E.coli GST
    Human SRC-1358H Recombinant Human SRC protein, His/GST-tagged Insect Cell His/GST
    Human SRC-191H Recombinant Human SRC, GST-tagged E.coli GST
    Human SRC-1923H Recombinant Human SRC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SRC-192H Recombinant Human SRC, SH3 Domain, GST-tagged E.coli GST
    Human SRC-22H Recombinant Human SRC protein, His-tagged E.coli His
    Human SRC-2747H Recombinant Human SRC Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SRC-2947H Recombinant Human SRC, GST-tagged E.coli GST
    Human SRC-29697TH Native Human SRC E.coli N/A
    Human SRC-381H Recombinant Human SRC Mammalian Cell His
    Human SRC-433H Recombinant Human SRC, GST-tagged, Active Sf9 Insect Cell GST
    Human SRC-487HCL Recombinant Human SRC cell lysate Insect Cell N/A
    Human SRC-533H Recombinant Human SRC protein, His-tagged Insect Cell His
    Human SRC-575H Recombinant Human SRC, GST-tagged E.coli GST
    Human SRC-79H Recombinant Human SRC protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse SRC-585MCL Recombinant Mouse SRC cell lysate Insect Cell N/A
    Mouse Src-593M Recombinant Mouse Rous Sarcoma Oncogene, Domain E.coli N/A
    Mouse Src-6122M Recombinant Mouse Src Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Src-907M Recombinant Mouse Src, His & GST tagged Insect Cell His/GST
    Mouse Src-99M Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain E.coli N/A
    Rhesus Macaque SRC-4460R Recombinant Rhesus monkey SRC Protein, His-tagged Mammalian Cell His
    Chicken SRC-7007C Recombinant Chicken SRC Mammalian Cell His
    Zebrafish SRC-1128Z Recombinant Zebrafish SRC Mammalian Cell His
    RSV Src-546R Recombinant RSV Src, GST-tagged Sf9 Insect Cell GST
    Kit-0800 c-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A

    SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway MAP2K2; AKT1; HBEGFB; HRAS; AKT2L; PRKCBA; MYCB; PAK1; PLCG2; PIK3R2
    Rap signaling pathway VAV2; FARP2; FGF10; ACTB; MAPK12; LCP2; PDGFD; FIGF; PARD6A; DOCK4
    Chemokine signaling pathway CCL16; CCL13; ARRB2; CXCL6; CCR1; CRK; CCL4; GRK6; ADRBK2; GNG5
    Endocytosis FAM125A; DNAJC6; STAM2; SH3GLB1B; IL2RGA; RAB5AA; GIT1; SH3GL1; GRK7; KITB
    VEGF signaling pathway PLCG2; RAC3B; MAP2K1; CDC42L; NOS3; SPHK2; PIK3CA; VEGFA; MAP2K2A; PRKCG
    Focal adhesion MYL12B; COL6A2; MAPK6; LAMB4; ITGA9; AKT2; MAPK8A; PARVB; ACTB1; PTK2AA
    Adherens junction MAPK3; CSNK2B; CSNK2A2A; RHOAA; PTPRFB; CDC42L; FYNB; TCF7; ACTN1; NLK1
    Tight junction MYL2; MYH9; PPP2CB; MAGI1B; MYH10; HRASA; PRKCDA; CLDN9; ACTN3B; ACTB1
    Platelet activation PIK3R5; GP1BA; NOS3; PLCB2; FCGR2A; GNAI2; GNAQ; PLA2G4A; AKT1; PRKACB
    Inflammatory mediator regulation of TRP channels PRKACB; CYP2C37; PPP1CA; MAP2K3; HTR2A; PPP1CC; BDKRB1; PLCB4; MAPK9; IL1B
    Regulation of actin cytoskeleton PPP1CA; VCL; PAK2A; FGF20B; PIK3R5; RRAS; PIK3R1; ARPC5LB; ACTN2B; MAP2K2B
    GnRH signaling pathway CALM1; MAPK14A; MAPK13; MAP3K1; GNA11B; CAMK2D; CAMK2D2; GNAQ; CACNA1SB; CALM3A
    Estrogen signaling pathway PLCB1; MAP2K1; PIK3CA; GNAI3; MMP2; HSP90B1; AKT2; HSPA1L; MAP2K2; PLCB2
    Prolactin signaling pathway ESR2; CSN2; PIK3CA; MAP2K1; PIK3R1; GRB2; SOCS2; CCND2; GALT; RAF1
    Thyroid hormone signaling pathway PIK3R2; ATP1A2; HDAC3; HRAS; MED12L; MDM2; SRC; MED12; NCOR1; PLCD4
    Oxytocin signaling pathway MAPK3; ELK1; CACNA2D1; ACTB; PLCB2; ITPR1; CALML3; PRKAA1; SRC; GNAI2
    Bacterial invasion of epithelial cells DNM1; WASF2; PIK3R5; HCLS1; SHC1; FN1; ITGB1; SHC4; BCAR1; ACTB
    Epithelial cell signaling in Helicobacter pylori infection CXCL1; ATP6V1E1; PTPN11; ATP6V0A4; IL-8; CDC42; MAPK10; F11R; ATP6V0A2; NOD1
    Tuberculosis IL23; TLR9; HLA-DPB1; SPHK1; Il23a; CASP9; CAMK2D; TGFB1; ITGB2; IFNB1
    Hepatitis B IFN-a; TNF; STAT4; IFNA7; PTK2B; HSPG2; PRKCA; TLR2; STAT6; FOS
    Viral carcinogenesis PXN; TBPL1; GSN; KRAS; PIK3CG; HIST1H2BD; GTF2A1L; CCND3; HDAC3; GTF2B
    Proteoglycans in cancer TIMP3; FZD8; ERBB4; FZD1; LUM; FZD2; MAP2K1; SLC9A1; ITGA2; PPP1R12B
    Bladder cancer MAPK1; UPK3A; CDH1; MAPK3; HRAS; HBEGF; CDK4; MMP1A; MAP2K2; RASSF1

    SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.

    Function Related Protein
    SH2 domain binding LILRB1; SRC; SQSTM1; DLC1; SYNGR3; AFAP1L2; MS4A2; SYP; PAG1; INPPL1
    SH3/SH2 adaptor activity SH3BP2; GRB14; ARHGAP1; GRAP; ITSN2; GAB1; TOB1; SH2D1A; LAT; CRKL
    enzyme binding CYB5A; SNX12; NOTCH1; POR; AKIRIN2; ACAT1; ARRB2; RYR2; ZFP36; GNB2L1
    ephrin receptor binding SIPA1L1; NTRK1; SRC; CDK5R1; EFNA4; EFNA3; EFNA1; EPHA4; EFNA3B; PIK3CG
    growth factor receptor binding FYN; SLC9A3R1; APP; SRC
    heme binding CYP2F2; CYP2C8; CYP3A4; HBG1; CYP3A5; CBSA; CYP2J5; PTGS2A; CYP4F3; NENF
    hormone receptor binding JAK3; TNK1; TNK2; JAK2B; TNK2B; SRC; JAK2A
    integrin binding EDIL3; ADAM10; COL5A1; ITGA5; THBS1; ANGPTL3; MMP14; VCAM1; SFRP2; ITGA3
    ion channel binding HTT; S100A10; ACTN2; YES1; KCNE2; GPD1L; PIRT; PACS1A; KCNB1; PANX1
    kinase activity SRPK1A; SPS2; BAIAP2L1A; Fert2; EPHB4B; SMG1; PFKFB2A; NME2A; LMTK2; CDC7
    kinase binding STRADA; PER1; PRKCD; MOBKL1A; PER3; PFKFB1; PTPN22; PIP5K1A; WWC3; CHP
    non-membrane spanning protein tyrosine kinase activity TNK2; EIF2AK2; FYNB; RIPK2; ZNF143B; WEE1; JAK2B; PTK6; PTK2AA; ABL1
    phosphoprotein binding PKD2; LRP11; PLAT; THRAP3; TOX3; ARR3; TBL2; YWHAE; MID2; DPYSL3
    protein binding SPG20; TLR13; ADCYAP1; RBMX2; NEK3; RTN3; RAD23A; VAMP1; POLRMT; TBX1
    protein kinase activity DYRK1A; SRPK1; CSNK1D; BMPR2A; GM7168; EIF2AK3; CDK5R1; OXSR1B; CSNK1G3; STK35L
    protein tyrosine kinase activity EPHB2B; ZAP70; CLK4; IGF1RB; WEE2; MAP2K3; CAMKK2; DYRK1B; BAZ1B; TNK1
    receptor binding LTA; F2; NPPC; P2RX7; BLK; SMARCD3; FZD1; IL1RAPL1; ADAM10; WNT5B
    scaffold protein binding IKBKB; GRID2; CIT; TREM2; DLG4; VIM; CACNA1H; NLGN4X; KCNA5; CHUK

    SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.

    PTPN1; PTK2

    Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
    He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).

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