SRC

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SRC

Official Full Name v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Background This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Synonyms SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • RSV
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SRC-004H Recombinant Human SRC Protein, GST-tagged Insect cell GST
    Human SRC-3525H Recombinant Human SRC protein, His-tagged E.coli His
    Human SRC-3526H Recombinant Human SRC protein E.coli N/A
    Human SRC-1100H Recombinant Human SRC protein, GST-tagged E.coli GST
    Human SRC-1358H Recombinant Human SRC protein, His/GST-tagged Insect Cell His/GST
    Human SRC-191H Recombinant Human SRC, GST-tagged E.coli GST
    Human SRC-1923H Recombinant Human SRC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SRC-192H Recombinant Human SRC, SH3 Domain, GST-tagged E.coli GST
    Human SRC-22H Recombinant Human SRC protein, His-tagged E.coli His
    Human SRC-2747H Recombinant Human SRC Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SRC-2947H Recombinant Human SRC, GST-tagged E.coli GST
    Human SRC-29697TH Native Human SRC E.coli N/A
    Human SRC-381H Recombinant Human SRC Mammalian Cell His
    Human SRC-433H Recombinant Human SRC, GST-tagged, Active Sf9 Insect Cell GST
    Human SRC-487HCL Recombinant Human SRC cell lysate Insect Cell N/A
    Human SRC-533H Recombinant Human SRC protein, His-tagged Insect Cell His
    Human SRC-575H Recombinant Human SRC, GST-tagged E.coli GST
    Human SRC-79H Recombinant Human SRC protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse SRC-585MCL Recombinant Mouse SRC cell lysate Insect Cell N/A
    Mouse Src-593M Recombinant Mouse Rous Sarcoma Oncogene, Domain E.coli N/A
    Mouse Src-6122M Recombinant Mouse Src Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Src-907M Recombinant Mouse Src, His & GST tagged Insect Cell His/GST
    Mouse Src-99M Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain E.coli N/A
    Rhesus Macaque SRC-4460R Recombinant Rhesus monkey SRC Protein, His-tagged Mammalian Cell His
    Chicken SRC-7007C Recombinant Chicken SRC Mammalian Cell His
    Zebrafish SRC-1128Z Recombinant Zebrafish SRC Mammalian Cell His
    RSV Src-546R Recombinant RSV Src, GST-tagged Sf9 Insect Cell GST
    Kit-0800 c-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A

    SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway RPS6KB1; ELK1; PIK3R1; PTK2AB; SOS1; MAPK3; ERBB4A; SHC2; GSK3B; PAK6B
    Rap signaling pathway THBS1; Itgam&Itgb2; PRKD1; MAP2K2; MAPK13; FGF21; RRAS; PRKCZ; PIK3R5; GRIN2B
    Chemokine signaling pathway PIK3CA; GNAI1; PLCB2; CX3CL1; IKBKB; PIK3R3; NFKB1; CCL6; CCL18; WAS
    Endocytosis CYTH1; CAPZA3; ADRB3; PARD6A; RAB8A; AP2M1B; WASB; GRK7; CLTCA; RAB11FIP5
    VEGF signaling pathway HRASB; MAPKAPK3; MAP2K2A; PLCG2; RAF1; MAPK12; HRASA; NFATC2; AKT1; VEGFAB
    Focal adhesion RHOAC; GSK3B; ITGA3; COL11A2; SRC; COL5A1; ITGB5; FLNB; ITGA6B; MYL9A
    Adherens junction CTNNA1; CTNNA2; CSNK2B; ACTN4; SNAI2; AASS; RAC3; ACTB1; RHOAA; LMO7A
    Tight junction GNAI1; CLDN1; PPP2R2BB; PRKCB; CLDN20; RHOAC; MYH1C; CLDN9; ACTN2B; ACTN3B
    Gap junction GNAI2A; GNAQ; PRKACG; MAP2K2B; TUBB2B; GNAIA; ADCY1B; GRB2A; TJP1; TUBB6
    Platelet activation GP5; APBB1IP; SYK; FCER1G; VASP; GNAS; COL27A1; PLCB1; GNAQ; STIM1
    GABAergic synapse SLC12A5; GLUL; PRKCA; GABARAPL1; GNG12; GABRA6; GNB1; SLC6A1; GNG10; GLS
    Inflammatory mediator regulation of TRP channels ACCN5; PRKCA; CYP2C55; F2RL1; PPP1CA; CALM3; PRKCQ; PLCB2; PIK3CB; CYP2J6
    Regulation of actin cytoskeleton MAP2K1; BAIAP2A; BDKRB1; FGF22; SSH3; ARPC5LA; ITGB1A; ARPC4L; CHRM5A; ITGB1B.2
    GnRH signaling pathway GRB2; PRKACBA; ADCY2B; MAP2K6; MAP2K2B; CAMK2D1; PRKACG; KRAS; CALM3A; MAPK12
    Estrogen signaling pathway GRB2; KRAS; FOS; PIK3CG; CALM4; GNAQ; SRC; HSP90B1; PRKACG; HRAS
    Prolactin signaling pathway GALT; SIRPA; SOS1; PIK3CD; MAPK12; TH; NFKB1; INS; SOCS1; SOCS5
    Thyroid hormone signaling pathway KAT2B; AKT2; PIK3CB; SLC16A10; THRA; ITGB3; ATP1A4; SRC; DIO2; NRAS
    Oxytocin signaling pathway PPP1CC; PIK3R5; CAMK2B; CAMK2A; CD38; ITPR3; CALML5; PPP3R1; PRKAG2; PLCB3
    Bacterial invasion of epithelial cells ARPC4; DNM2; PIK3CG; ARPC2; CDC42; PIK3CA; ELMO1; ARPC3; MET; CTNNA3
    Epithelial cell signaling in Helicobacter pylori infection PLCG1; TJP1; F11R; ATP6V1A; ATP6V0A2; ADAM17; CDC42; LYN; IL-8; MAPK11
    Shigellosis ROCK2; NFKBIA; SRC; UBE2D2; RELA; PFN1; BTRC; WASL; ABL1; ELMO2
    Tuberculosis ITGAM; IL1A; MRC1; Ifna11; Il23a; Il12b; CYCS; Ifna15; NFYB; IFNGR1; IL12B
    Hepatitis B PIK3CG; PIK3CA; MMP9; MAP2K4; STAT4; TICAM2; NFATC4; PTEN; NFATC2; IFNA5
    Viral carcinogenesis TBPL2; PKM2; TRAF2; HIST1H4G; MRPS18B; KAT2A; HIST3H2BB-PS; ACTN1; PRKACG; HDAC10
    Proteoglycans in cancer TWIST2; CAV3; WNT9A; MMP2; SDC4; MET; ITGB3; CAV2; NANOG; ANK2
    Bladder cancer MMP9; MAPK3; HBEGF; DAPK1; CCND1; THBS1; IL-8; CDK4; TP53; DAPK2

    SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding GRK1B; NTRK3A; HSP90AA1.1; CHUK; LMTK2; CDK3; RAD51C; ALPK1; EPHB1; CDK10
    SH2 domain binding KHDRBS2; LAX1; LAT2; SYNGR3; SKAP1; DAG1; SYP; AFAP1L2; DLC1; NUP62
    SH3/SH2 adaptor activity GRB14; SH2D3A; GRB7; SH2D2A; SLA2; LAT; LASP1; BLNK; GRAP; GRB10
    enzyme binding TSPAN5; DNM2; ABCD1; PRMT1; CUTA; RPS19BP1; ATXN10; TSPAN10; NPM2; MSH2
    ephrin receptor binding ANKS1B; EFNB3B; CHN1; SIPA1L1; EFNA2; EFNB2; EFNA3B; CRK; CDK5; EFNA1B
    growth factor receptor binding APP; SRC; SLC9A3R1; FYN
    heme binding HBE1; CYP2C37; HBBE2; CYGB; CYP2X9; CYP7A1; HBAD; CYP8B2; CYP2AA12; NOS1
    hormone receptor binding TNK2; JAK2B; TNK1; JAK2A; JAK3; TNK2B; SRC
    integrin binding ITGA3; CYR61L1; ITGB6; ITGB1; THBS1; CD226; DST; S1PR3; SYK; SRC
    ion channel binding ASPH; TCAP; CTNNB1; PIRT; PKP2; RIMS3; FXYD1; PACS2; PACS1; CAMK2D
    kinase activity PAK2B; CDK5; NEK4; STK30; PIP5K1BA; PI4KAB; AKT1; PRKAR2AB; SGK2A; PRKACBB
    kinase binding FAS; PTPN22; PRKAA1; TAX1BP1; DUSP12; SIT1; CEBPB; C2orf44; NTRK1; CHP1
    non-membrane spanning protein tyrosine kinase activity PRKCD; PTK6; TEC; MELK; LCK; RIPK2; MATK; ITK; TNK2B; YES1
    phosphoprotein binding TRPV1; SNCA; SAG; PITX2; RRAGA; MTOR; FKBP4; CSNK1D; URI1; MID2
    protein binding CXCL10; C7orf50; ARMC7; ZWILCH; SH3PXD2A; ANKRD1; PDCD5; AGFG1; RCN3; EYA2
    protein kinase activity EPHA4B; GUCY2F; CAMK2D2; LIMK1A; CAMKVB; STK25A; CSNK1DA; PIK3R4; PRKCHA; CAMK1GB
    protein tyrosine kinase activity SRMS; TTN; PTK2; TYK2; DYRK1A; TNK1; CSF1RA; ABL1; PTK6B; ABL2
    receptor binding PVRL4; GAS6; SLC39A1; ENSA; HFE; WNT7A; GSDMA2; NPPA; PTK2AB; FGF8A
    scaffold protein binding CASP8; NLGN4X; ATP2B4; ADCY6; IKBKB; TREM1; GRIN2A; MAPK3; KRT18; CACNA1H

    SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.

    PTPN1; PTK2

    Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
    He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).

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