src
Share
  • Official Full Name
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • Background
  • This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2
Cat.#:SRC-2747HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SRC Protein, MYC/DDK-tagged
+Inquiry
Cat.#:SRC-1100HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, GST-tagged
+Inquiry
Cat.#:SRC-1358HTag:His/GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His/GST-tagged
+Inquiry
Cat.#:SRC-192HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, SH3 Domain, GST-tagged
+Inquiry
Cat.#:SRC-22HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
+Inquiry
Cat.#:SRC-2947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
+Inquiry
Cat.#:SRC-381HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SRC
+Inquiry
Cat.#:SRC-533HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
+Inquiry
Cat.#:SRC-575HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
+Inquiry
Cat.#:SRC-79HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human SRC protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:Src-907MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Src, His & GST tagged
+Inquiry
Cat.#:SRC-4460RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SRC Protein, His-tagged
+Inquiry
Cat.#:SRC-7007CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SRC
+Inquiry
Cat.#:SRC-1128ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SRC
+Inquiry
Cat.#:Src-546RTag:GST
Source (Host):Sf 9 insect cellsSpecies:RSV
Product nameRecombinant RSV Src, GST-tagged
+Inquiry
Cat.#:SRC-191HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
+Inquiry
Cat.#:SRC-433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SRC, GST-tagged, Active
+Inquiry
Cat.#:Src-593MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, Domain
+Inquiry
Cat.#:Src-99MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, SH3 Domain
+Inquiry
Cat.#:SRC-29697THTag:
Source (Host):E. coliSpecies:Human
Product nameNative Human SRC
+Inquiry
Cat.#:SRC-487HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SRC cell lysate
+Inquiry
Cat.#:SRC-585MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SRC cell lysate
+Inquiry
Cat.#:Kit-0800Tag:
Source (Host):Species:
Product namec-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit
+Inquiry

Involved Pathway

SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PTK2AB; MAP2K7; SRC; HBEGFA; PLCG1; NRAS; GRB2; GAB1; GSK3AA; ERBB3B
Rap signaling pathway
FGF5; PRKCG; CDC42; Itgam&Itgb2; PIK3CB; THBS1; MAP2K6; ARAP3; PDGFA; LPAR3
Chemokine signaling pathway
PIK3R2; CCL25; CCL27; CRK; VAV1; PTK2B; IKBKG; CCL17; ADRBK2; PTK2
Endocytosis
ARPC4L; ADRBK2; TGFB1; ARF6; PSD2; CAV2; EHD1A; HLA-C; HSPA6; CHMP6
VEGF signaling pathway
SPHK1; MAPK13; MAP2K2A; HRASA; PLCG2; MAPKAPK2A; HRASB; RAC1B; PLA2G4AA; PTK2
Focal adhesion
COL6A1; STYK1; IBSP; COL5A2A; PDGFAA; VAV1; SOS1; CAPN2B; SHC2; PTK2AA
Adherens junction
WASF3B; RHOAB; NLK2; ACTN4; WASF3; INSRB; LEF1; PTPRJ; ACP1; SNAI1
Tight junction
PRKCG; AKT3A; CLDN1; GNAI1; OCLNA; CLDNK; RAB13; JAM2; ACTN1; JAM2A
Gap junction
MAP2K1; TUBA8L; PRKACG; MAP3K2; PDGFB; TUBA4A; PLCB3; CDK1; EGFRA; CSNK1DB
Platelet activation
ORAI1; ACTB; FCER1G; ROCK2; MYL12A; FGG; GP1BA; ITGB1; MAPK1; GP1BB
GABAergic synapse
GABRA5; GABRG3; GLUL; GAD2; GABRP; GABRG2; PRKCA; GABRA4; SLC38A5; GNGT2
Inflammatory mediator regulation of TRP channels
MAPK11; TRPV4; ASIC5; PLCB4; MAPK8; ASIC1; ACCN4; TRPM8; PPP1CC; PTGER4
Regulation of actin cytoskeleton
PAK6; CYFIP1; VCLA; ITGA1; DIAPH1; PIK3R5; IQGAP2; MYLPFB; SCINLB; INSB
GnRH signaling pathway
LHB; PTK2BB; GNRHR2; MAPK1; PRKACA; PLA2G4D; PRKCDA; MAPK8A; MMP14; Adcy4
Estrogen signaling pathway
SHC4; KCNJ5; GNAI3; PLCB4; PRKACG; CALM3; HSPA1L; GNAQ; GNAO1; KCNJ9
Prolactin signaling pathway
IRF1; NEK3; MAPK13; MAPK1; PIK3R1; SOCS4; PIK3CD; SRC; SHC4; INS2
Thyroid hormone signaling pathway
RXRG; NCOR1; ATP2A2; PLCG1; PFKP; SLCO1C1; ATP1A3; HDAC3; PIK3R5; TRP53
Oxytocin signaling pathway
GUCY1A3; PIK3CD; RHOA; PLCB2; MAP2K1; NFATC4; TRPM2; CACNB3; CACNB1; PPP1R12C
Bacterial invasion of epithelial cells
SHC1; CAV1; CTNNA3; CDH1; GAB1; PIK3CD; WAS; HCLS1; CTNNA2; MAD2L2
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1C1; CXCL1; ATP6V1C2; ATP6V1B1; PLCG2; PTPN11; ATP6V1F; ATP6V0A1; NFKB1; MAPK12
Shigellosis
ACTB; UBE2D2; DIAPH1; RELA; ACTG1; PFN4; MAPK3; ITGB1; NFKB1; PFN1
Tuberculosis
HSPA9; LBP; Ifna15; TLR4; CD209A; RFXAP; ATP6V0C; CD74; HLA-DQB1; MAPK3
Hepatitis B
IFNA17; MAPK1; TLR3; ATF4; CREB5; Ifna15; CCND1; CREB3L1; CASP8; IFNA2
Viral carcinogenesis
HIST1H4A; EGR3; HNRNPK; HLA-F; HIST1H4I; ATF4; HDAC7; GTF2A2; HLA-C; CCNE1
Proteoglycans in cancer
PRKACG; ANK2; WNT5A; ITPR1; WNT11; FAS; ROCK1; GPC3; PIK3CA; MAPK3
Bladder cancer
E2F3; THBS1; RB1; MMP9; HBEGF; CDH1; CXCL8; IL-8; MAPK3; CDK4

Protein Function

SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYH11A; DYNC1H1; TLK1B; HIPK3; FYNA; KIF3A; PIP4K2C; TTLL13; CSNK2A1; ABCG4B
Function SH2 domain binding
Related Protein SHCBP1; CRK; LAX1; AFAP1L2; LILRB1; IRS1; GNB2L1; CTR9; NLK; MS4A2
Function SH3/SH2 adaptor activity
Related Protein SH3BGR; SH2B2; ARHGAP1; ITSN2; GRB7; FCRL2; GRAP; GRB10; KHDRBS1; CRKL
Function enzyme binding
Related Protein RCOR3; PPP3CB; HDAC10; SNRPD3; HIST1H2AI; HIST1H2AM; GOT2; UGT1A6; GSTM3; NOTCH1
Function ephrin receptor binding
Related Protein EFNA4; EFNB2; NTRK3; EFNB2B; SDCBP; CRK; CBL; EFNB2A; ANKS1B; FYN
Function growth factor receptor binding
Related Protein SRC; FYN; APP; SLC9A3R1
Function heme binding
Related Protein CYP1A2; IDO2; CYP2K22; CYCS; CYP2X9; CYP26B1; CYP2J6; PTGS2A; CYP4A11; CYP2W1
Function hormone receptor binding
Related Protein JAK2B; JAK2A; TNK2B; TNK1; TNK2; SRC; JAK3
Function integrin binding
Related Protein ACTN3; TNN; ESM1; GPNMB; TLN1; ADAM2; ADAM22; DMP1; CTGF; VTN
Function ion channel binding
Related Protein FGF12; RIMS1; CAMK2D; ABCC9; GRINA; KCNC1; PDE4B; PACS2; FAM115A; GPD1L
Function kinase activity
Related Protein PRKCBB; CAMK2A; PFKFB2A; JAK2A; MAP4K6; ADKB; LRRK2; MOB1BA; CDK5R1A; DCLK3
Function kinase binding
Related Protein TAX1BP1; ABI2; JAKMIP2; PER1; STUB1; NTRK1; SLC2A1; CEBPA; CDC37; HAP1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein FES; TEC; ZNF143B; TYK2; ABL2; PTK6B; PTK2BB; YES1; FYNB; JAK1
Function phosphoprotein binding
Related Protein ARR3; SFN; RRAGA; YWHAE; URI1; THRAP3; PAFAH1B1; TRPV1; LRP11; MID2
Function protein binding
Related Protein CDCP1; TCEB1; FGF19; NOSTRIN; STRADA; ZNF238; DST; CENPL; CTNNA2; C10orf18
Function protein kinase activity
Related Protein KDRL; ROCK2B; NPR2; CSNK1G2B; PAK2; CAMK1GB; ROCK2A; PTK7A; BSK146; NTRK3A
Function protein tyrosine kinase activity
Related Protein ABL2; PDGFRB; LYN; TNK2B; CLK4; EPHB3A; TNK2; EPHA4A; DYRK4; NEK1
Function receptor binding
Related Protein GSTM2; CRAT; PTK2B; MATK; IDE; ADM; CRH; KNG1; SNX17; PRDX5
Function scaffold protein binding
Related Protein NOS1; KRT18; ATP2B4; CACNA1H; CHRNA7; DSP; MDM2; PDE4D; TREM1; KRT5

Interacting Protein

SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.
PTPN1; PTK2

SRC Related Articles

Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).

SRC Related Gene Family

GPCRs TGF