Native Human SRC

• Cat.No.: SRC-29697TH
• Product Overview: Fusion protein, corresponding to amino acids 84-145 of Human Src and proprietary protein, approximately 33kDa.

Specification

• Description: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
• Source: E. coli
• Form: Lyophilised:Reconstitute within H2O bid.
• Purity: Immunogen affinity purified
• Storage buffer: Preservative: NoneConstituents: 50mM Potassium phosphate, 20mM Sodium chloride, pH 6.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.Contains 1 protein kinase domain.Contains 1 SH2 domain.Contains 1 SH3 domain.

Gene Information

• Gene Name: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ]
• Official Symbol: SRC
• Synonyms: SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); SRC1, v src avian sarcoma (Schmidt Ruppin A 2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; ASV; c src
• Gene ID: 6714
• mRNA Refseq: NM_005417
• Protein Refseq: NP_005408
• MIM: 190090
• Uniprot ID: P12931
• Chromosome Location: 20q12-q13
• Pathway: ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha-synuclein signaling, organism-specific biosystem
• Function: ATP binding; SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; heme binding