Active Recombinant Human TNFRSF1B, Fc-tagged, Biotinylated

Cat.No. : TNFRSF1B-708H
Product Overview : The recombinant human TNFR2-Fc fusion is expressed as a 460 amino acid protein consisting of Leu23 - Asp257 region of TNFR2 (UniProt accession #P20333) and a C-terminal Fc from human IgG1, which exists as a dimer/tetramer under non-reducing conditions.
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Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its ligand TNF and inhibits TNF-mediated biological activities including NF-κB activation and cytotoxicity in the mouse L929 fibrosarcoma cells.
Molecular Mass : Calculated molecular mass (kDa): 50.5; Estimated by SDS-PAGE under reducing condition (kDa): 75-85
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition.
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [ Homo sapiens ]
Official Symbol : TNFRSF1B
Synonyms : TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; TNFR2; tumor necrosis factor receptor superfamily member 1B; CD120b; p75; TNF R II; TNF R75; TNFBR; TNFR80; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2; TBPII; TNFR1B; TNF-R75; p75TNFR; TNF-R-II;
Gene ID : 7133
mRNA Refseq : NM_001066
Protein Refseq : NP_001057
MIM : 191191
UniProt ID : P20333
Chromosome Location : 1p36.22
Pathway : Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : protein binding; receptor activity; tumor necrosis factor-activated receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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