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Active Recombinant Human UGT1A8 Protein

Cat.No. : UGT1A8-99H
Product Overview : Recombinant human UGT1A8 protein without tag was expressed in insect cells.
  • Specification
  • Gene Information
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Description : This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.
Source : Insect cells
Species : Human
Bio-activity : UGT Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 100 mM Tris-HCl (pH 7.5) containing 5 mM magnesium chloride and 2 mM UDPGA. Alamethicin (10 μg/ml final concentration) is added to kinetics tests only)
Substrate: 4-methylumbelliferone
Linear with time up to: 30 min(Determined at 300 μM substrate, using a protein concentration of 100 μg/ml)
Linear with protein up to: 400 μg/ml(Determined at 300 μM substrate, using an incubation time of 5 min)
Vmax: 16227 pmol/min/mg protein
Km: 510 μM
Usage : For laboratory (research) purposes only
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : Protein Concentration: 5 mg/ml
Storage Buffer : 25 mM Tris-acetate (pH 7.6), 10% (v/v) glycerol, 1 mM EDTA
Gene Name : UGT1A8 UDP glucuronosyltransferase family 1 member A8 [ Homo sapiens (human) ]
Official Symbol : UGT1A8
Synonyms : UGT1A8; UDP glucuronosyltransferase family 1 member A8; GNT1; UGT1; UDPGT; UGT1A; UGT1H; UGT-1A; UGT-1H; UGT1.1; UGT1.8; UGT1A1; UGT1-01; UGT1-08; UGT1A8S; hUG-BR1; UDPGT 1-8; UDP-glucuronosyltransferase 1-8; Bilirubin-specific UDPGT isozyme 1; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A8; UDPGT 1-1
Gene ID : 54576
mRNA Refseq : NM_019076
Protein Refseq : NP_061949
MIM : 606433
UniProt ID : Q9HAW9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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