Active Recombinant Mouse Cd40, His-tagged
Cat.No. : | Cd40-86M |
Product Overview : | Optimized DNA sequence encoding extracellular domain of Mouse CD40 including a C-terminal His tag was expressed in HEK293 cells. |
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Description : | The CD40 molecule is a 45- 50-kDa type I phosphorylated glycoprotein that belongs to the tumor necrosis factor receptor superfamily and was initially considered to be a growth factor receptor on B cells. The interaction of CD40 with its natural ligand, CD154, is a crucial step in T cell-dependent B cell activation and differentiation. The cellular events triggered in CD40-positive cells following CD40/CD154 interactions are not restricted to B cells only but can also be triggered in dendritic cells, monocytes, epithelial cells, endothelial cells, and fibroblasts. Thus, CD40 ligation mediates a broad variety of immune and inflammatory responses. |
Source : | HEK293 cells |
Species : | Mouse |
Tag : | His |
Form : | Recombinant Mouse CD40 is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose. |
Bio-activity : | The activity was tested by the ability of immobilized recombinant mouse CD40 to bind Human CD40 Ligand with a linear range of 10-500 ng/ml. |
Molecular Mass : | Recombinant CD40 is a protein consisting of 180 amino acid residue subunits, due to glycosylation migrates as an approximately 30kDa protein on SDS-PAGE. |
Endotoxin : | Endotoxin content was assayed using a LAL gel clot method.Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg). |
Purity : | >97%, as determined by SDS-PAGE and HPLC |
Storage : | Recombinant CD40 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months. Avoid repeated freeze/thaw cycles. |
Gene Name : | Cd40 CD40 antigen [ Mus musculus (house mouse) ] |
Official Symbol : | Cd40 |
Synonyms : | Cd40; IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5; AI326936; CD40 antigen; tumor necrosis factor receptor superfamily member 5; CD40L receptor; B-cell surface antigen CD40; T-cell differentiation antigen; tumor necrosis factor receptor superfamily, member 5 |
Gene ID : | 21939 |
mRNA Refseq : | NM_011611 |
Protein Refseq : | NP_035741 |
UniProt ID : | P27512 |
Chromosome Location : | 2 H3; 2 85.38 cM |
Pathway : | Allograft rejection; Autoimmune thyroid disease; Epstein-Barr virus infection |
Function : | antigen binding; enzyme binding; protein binding |
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CD40-1087H | Recombinant Human CD40 Protein (Met1-Arg193), His-tagged, Biotinylated | +Inquiry |
CD40-371H | Active Recombinant Human CD40 Protein, Fc & Avi-tagged, Biotinylated | +Inquiry |
Cd40-8727R | Recombinant Rat Cd40 protein(Met1-Arg193), His-tagged | +Inquiry |
◆ Lysates | ||
CD40-1254CCL | Recombinant Cynomolgus CD40 cell lysate | +Inquiry |
CD40-1831MCL | Recombinant Mouse CD40 cell lysate | +Inquiry |
CD40-2617HCL | Recombinant Human CD40 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.
As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.
Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.
Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.
Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.
Customer Reviews (3)
Write a reviewIts utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.
The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.
CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.
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