cd40

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cd40

Official Full Name CD40 antigen
Background CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B -cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. The CD40 gene is localized to the long arm of chromosome 20, bands q12-q13.2. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
Synonyms CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CD_antigen=CD40; CD40 antigen; Dacetuzumab; 880486-59-9; Teneliximab; 299423-37-3
    • Species :
    • Canine
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • CHO cells
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Rabbit
    • Wheat Germ
    • Yeast
    • Tag :
    • Avi
    • Fc
    • Fc/Avi
    • His
    • GST
    • hFc
    • hIgG/His
    • Flag
    • StrepII
    • T7
    • HlgG1 Fc
    • human
    • IgG1
    • Mouse
    • IgG2a
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD40-051H Recombinant Human CD40 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi
    Human CD40-07H Recombinant Human CD40 Protein, hIgG/His-tagged HEK293 hIgG/His
    Human CD40-837H Recombinant Human CD40 protein, hFc-tagged Mammalian cell hFc
    Human CAB11500RH Rabbit Anti-Human CD40 Molecule, TNF Receptor Superfamily Member 5 Monoclonal Antibody Rabbit N/A
    Human CD40-017H Recombinant Human CD40 protein, Fc-tagged (HPLC-verified) HEK293 human/IgG1/Fc
    Human CD40-0810H Recombinant Human CD40 Protein Wheat Germ N/A
    Human CD40-0811H Recombinant Human CD40 Protein, His-Flag-StrepII-Tagged Human Cell His/Flag/StrepII
    Human CD40-0812H Recombinant Human CD40 Protein, GST-Tagged Wheat Germ GST
    Human CD40-105H Recombinant Human CD40, MIgG2a Fc-tagged CHO Fc
    Human CD40-106H Recombinant Human CD40, HIgG1 Fc-tagged CHO Fc
    Human CD40-107H Recombinant Human CD40 Protein, His-tagged CHO His
    Human CD40-107HG GMP Recombinant Human CD40 protein, His-tagged HEK293 His
    Human CD40-1087H Recombinant Human CD40 Protein (Met1-Arg193), His-tagged, Biotinylated HEK293 His
    Human CD40-108H Recombinant Human CD40 Protein, Fc-tagged CHO Fc
    Human CD40-108HA Recombinant Human CD40 protein, Fc-tagged, APC labeled CHO Fc
    Human CD40-108HP Recombinant Human CD40 protein, Fc-tagged, R-PE labeled CHO Fc
    Human CD40-174H Recombinant Human CD40, Fc-His tagged Human Cell Fc/His
    Human CD40-202H Recombinant Human CD40 protein, His/Fc-tagged, Biotinylated HEK293 His/Fc
    Human CD40-2221H Recombinant Human CD40 protein, His-tagged HEK293 His
    Human CD40-2222H Recombinant Human CD40 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human CD40-2617HCL Recombinant Human CD40 cell lysate Human Cell N/A
    Human CD40-27810TH Recombinant Human CD40, Fc-tagged Fc
    Human CD40-369H Recombinant Human CD40 protein, Hi & Fc & Avi-tagged, Biotinylated HEK293 His/Fc/Avi
    Human CD40-371H Recombinant Human CD40 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human CD40-389H Recombinant Human CD40 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human CD40-493H Recombinant Human CD40, Fc Chimera HEK293 Fc
    Human CD40-4980H Recombinant Human CD40 Molecule, TNF Receptor Superfamily Member 5 Human N/A
    Human CD40-5119H Recombinant Human CD40, His-tagged E.coli His
    Human CD40-518H Recombinant Human CD40 molecule, TNF receptor superfamily member 5, His-tagged E.coli His
    Human CD40-577H Recombinant Human CD40, Fc-tagged, Biotinylated Human Cell Fc
    Human DMAB6033MH Mouse Anti-Human CD40 Monoclonal Antibody Mouse N/A
    Mouse CD40-1088M Recombinant Mouse CD40 Protein (Met1-Arg193), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Mouse Cd40-1715M Recombinant Mouse CD40 Antigen, Fc-His Mammalian cells His
    Mouse CD40-1831MCL Recombinant Mouse CD40 cell lysate Human Cell N/A
    Mouse Cd40-325M Recombinant Mouse CD40 Protein, Fc-tagged HEK293 Fc
    Mouse Cd40-4981M Recombinant Mouse CD40 Antigen Mouse N/A
    Mouse Cd40-6717M Recombinant Mouse Cd40 protein, His & T7-tagged E.coli His/T7
    Mouse Cd40-6892M Recombinant Mouse Cd40, Fc-His tagged Human Cell Fc/His
    Mouse CD40-816M Recombinant Mouse CD40 Protein (Val24-Arg193), His-tagged Yeast His
    Mouse Cd40-81M Recombinant Mouse Cd40 protein, His-tagged Insect Cell His
    Mouse Cd40-86M Recombinant Mouse Cd40, His-tagged HEK293 His
    Mouse Cd40-87M Recombinant Mouse Cd40 protein, His-tagged HEK293 His
    Rat CD40-1262RCL Recombinant Rat CD40 cell lysate Human Cell N/A
    Rat Cd40-6718R Recombinant Rat Cd40 protein, His & T7-tagged E.coli His/T7
    Rat Cd40-8726R Recombinant Rat Cd40, Fc tagged Human Cell Fc
    Rat Cd40-8727R Recombinant Rat Cd40, His tagged Human Cell His
    Cynomolgus Monkey CD40-1254CCL Recombinant Cynomolgus CD40 cell lysate Human Cell N/A
    Cynomolgus CD40-23C Recombinant Cynomolgus CD40 Protein, His-tagged HEK293 His
    Cynomolgus CD40-85C Recombinant Cynomolgus CD40 protein, His-tagged HEK293 His
    Cynomolgus Monkey CD40-8823C Recombinant Cynomolgus CD40, Fc tagged Human Cell Fc
    Rhesus macaque CD40-388R Recombinant Rhesus macaque CD40 protein, Fc-tagged HEK293 human/IgG1/Fc
    Rhesus Macaque CD40-740R Recombinant Rhesus monkey CD40 Protein, His-tagged Mammalian Cell His
    Rhesus macaque CD40-741R Recombinant Rhesus macaque CD40 protein, His-tagged HEK293 His
    Rhesus CD40-8824C Recombinant Rhesus CD40 protein, His-tagged HEK293 His
    Canine CD40-001CCL Recombinant Canine CD40 cell lysate Human Cell N/A
    Canine CD40-153C Recombinant Canine CD40, LEVLFQ tagged Human Cell Fc/His
    Canine CD40-165C Recombinant Canine CD40, His-tagged Human Cell His
    Canine CD40-167C Recombinant Canine CD40, Fc tagged Human Cell Fc
    Canine CD40-928C Recombinant Canine CD40 Protein (Glu21-Ala194), His-tagged Yeast His
    Chicken CD40-6231C Recombinant Chicken CD40 Mammalian Cell His
    Zebrafish CD40-7316Z Recombinant Zebrafish CD40 Mammalian Cell His

    cd40 involved in several pathways and played different roles in them. We selected most pathways cd40 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with cd40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction GM2002; TNFRSF18; CSF2RA; CSH; IFNPHI1; CSF3; CXCL3; PDGFAA; BMP2; IL17B
    NF-kappa B signaling pathway TRAF2; PLCG1; BCL2; TRAF6; GM1987; NFKB2; TRAF5; ERC1; Ccl21c; CD40LG
    Cell adhesion molecules (CAMs) ITGAL; CD2; H2-AB1; HLA-DPA1; SDC1; ITGA6; PDCD1; OCLN; CLDN8; CLDN4
    Toll-like receptor signaling pathway IL-8; MAP2K2B; TOLLIP; IRF7; IFNA8; Ifna15; MAPK14A; MAPK10; AKT2; CCL3L1
    Intestinal i HLA-DRB5; CD40LG; HLA-DRB3; HLA-DPB1; TGFB1A; PIGR; MAP3K14; CCL25B; BLA; CD28
    ne network for IgA production HLA-DRB4; CXCL12B; CD80; CCL25; BLB1; TGFB1; HLA-DRB1; CD40LG; HLA-DRB5; LTBR
    Malaria TGFB1; TGFB2; ICAM1; ITGAL; COMP; IL6; THBS1; CD40; TGFB3; HBA1
    Toxoplasmosis HLA-DQB1; LAMC2; GNAI3; HLA-DPA1; IFNGR2; HLA-DRB4; HSPA8; ITGB1; MAPK8; RELA
    HTLV-I infection CANX; WNT1; NFKB2; FZD7; CDC16; FZD2; HLA-DRB3; TERT; LTA; WNT2
    Epstein-Barr virus infection SND1; HLA-DRB5; HLA-DQB1; CD40; TYK2; POLR2F; POLR2J3; RIPK1; PIK3CG; SNW1
    Transcriptional misregulation in cancer SIX4; HIST1H3E; ETV7; MLL1; REL; H3F3B; RXRA; MMP9; IGF1R; KDM6A
    Asthma HLA-DRB3; TNF; IL4; MS4A2; CD40LG; HLA-DQA2; HLA-DOA; FCER1G; HLA-DRA; RNASE3
    Autoi IFNA6; CD40; HLA-C; IFNA21; HLA-DRB4; FASLG; IFNA13; HLA-DPA1; IL4; IFNA7
    ne thyroid disease Ifna11; HLA-DMA; HLA-DOB; CD86; IFNA13; Il2; IFNA1; IFNA10; CD28; CD40LG
    Systemic lupus erythematosus HIST1H3C; FCGR1A; H3F3B; HIST2H2AC; C9; HIST1H2AH; HLA-DRB5; GM5077; HLA-DQB1; GM6026
    Allograft rejection Fasl; HLA-DOB; H2-AA; IL12B; HLA-A; HLA-DRB1; H2-AB1; HLA-DMB; GZMB; HLA-DOA
    Primary i CD79A; RFXAP; DCLRE1C; PTPRC; TAP1; IGLL1; TNFRSF13B; RAG2; CD40LG; IKBKG
    nodeficiency CD8B; RAG2; CD8B1; CD40; CD3E; ICOS; CD19; RAG1; IL7R; IKBKG
    Viral myocarditis CASP9; ABL1; HLA-DRB3; HLA-DRA; CCND1; CD80; H2-Q10; RAC2; H2-AB1; SGCD

    cd40 has several biochemical functions, for example, antigen binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cd40 itself. We selected most functions cd40 had, and list some proteins which have the same functions with cd40. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding CD40; IGJ; IGKV1-5; LAG3; LILRA2; TSPAN4; HNRNPM; IGHM; IGKC; IGLL1
    enzyme binding HDAC10; HAND2; Txn1; MDM4; ATG3; ADORA2A; PPP1R3D; LUC7L2; AKT1; VAPB
    protein binding ADRB3; RPAP3; NUMA1; ATP6V1G1; UCP3; FAM153C; ATL2; UBE2V1; CSN3; RAB7A
    receptor activity NR2C2; NLGN4X; TREM2; CD5; RAMP3; VMN1R40; NLGN4Y; IGSF1; MED16; CD244
    signal transducer activity DRD2L; OLFR508; DRD4-RS; CCR1L1; TRADD; MALT1; OLFR10; GNA12A; MRGPRA8; GNAI3
    tumor necrosis factor-activated receptor activity LTBR; EDA2R; TNFRSFA; CD40; TNFRSF4; TNFRSF10A; NRADD; FAS; TNFRSF11B; TNFRSF25
    ubiquitin protein ligase binding TNFRSF14; CCDC50; PDE4D; BRCA1; CUL1A; FBXW7; POLR2A; HSPA1L; PINK1; BCL2

    cd40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd40 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd40.

    TRAF2; TRAF6; TRAF3; 21362046; SGK1; OGT; KATNA1; TXN; PCMT1; FBL; CALR

    Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
    Cozza, EM; Cooper, TK; et al. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:325-336(2015).

    TNF

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