CD40 Protein

CD40

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CD40

Official Full Name CD40 antigen
Background CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B -cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. The CD40 gene is localized to the long arm of chromosome 20, bands q12-q13.2. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
Synonyms CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CD_antigen=CD40; CD40 antigen; Dacetuzumab; 880486-59-9; Teneliximab; 299423-37-3
    • Species :
    • Canine
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Homo sapiens (Human)
    • Human
    • Monkey
    • Mouse
    • Mus musculus (Mouse)
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • CHO cells
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293F
    • Human
    • Human Cell
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Rabbit
    • Wheat Germ
    • Yeast
    • Tag :
    • Avi
    • Fc
    • Fc/Avi
    • Fc/His
    • His
    • Fc-His(C-ter)
    • GST
    • hFc
    • hIgG/His
    • His(C-ter)
    • Flag
    • StrepII
    • T7
    • HlgG1 Fc
    • human
    • IgG1
    • LEVLFQ
    • Mouse
    • IgG2a
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD40-105H Active Recombinant Human CD40, MIgG2a Fc-tagged CHO Fc Inquiry
    Human CD40-106H Active Recombinant Human CD40, HIgG1 Fc-tagged CHO Fc Inquiry
    Human CD40-107H Active Recombinant Human CD40 Protein, His-tagged CHO His Inquiry
    Human CD40-108H Active Recombinant Human CD40 Protein, Fc-tagged CHO Fc Inquiry
    Human CD40-202H Active Recombinant Human CD40 protein, His/Fc-tagged, Biotinylated HEK293 His/Fc Inquiry
    Human CD40-369H Active Recombinant Human CD40 protein, Hi & Fc & Avi-tagged, Biotinylated HEK293 His/Fc/Avi Inquiry
    Human CD40-493H Active Recombinant Human CD40, Fc Chimera HEK293 Fc Inquiry
    Human CD40-577H Active Recombinant Human CD40, Fc-tagged, Biotinylated Human Cell Fc Inquiry
    Mouse Cd40-4981M Active Recombinant Mouse CD40 Antigen Mouse N/A Inquiry
    Mouse Cd40-86M Active Recombinant Mouse Cd40, His-tagged HEK293 His Inquiry
    Human CD40-051H Active Recombinant Human CD40 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Inquiry
    Human CD40-108HAF488 Active Recombinant Human CD40 Protein, Fc-tagged, Alexa Fluor 488 conjugated CHO Fc
    Human CD40-108HAF555 Active Recombinant Human CD40 Protein, Fc-tagged, Alexa Fluor 555 conjugated CHO Fc
    Human CD40-108HAF647 Active Recombinant Human CD40 Protein, Fc-tagged, Alexa Fluor 647 conjugated CHO Fc
    Human CD40-108HF Active Recombinant Human CD40 Protein, Fc-tagged, FITC conjugated CHO Fc
    Rabbit CD40-2151R Active Recombinant Rabbit CD40 protein, His-tagged HEK293 His Inquiry
    Human CD40-837H Active Recombinant Human CD40 protein, hFc-tagged Mammalian cell hFc Inquiry
    Human CD40-017H Recombinant Human CD40 protein, Fc-tagged (HPLC-verified) HEK293 human/IgG1/Fc Inquiry
    Human CD40-0810H Recombinant Human CD40 Protein Wheat Germ N/A Inquiry
    Human CD40-0811H Recombinant Human CD40 Protein, His-Flag-StrepII-Tagged Human Cell His/Flag/StrepII Inquiry
    Human CD40-0812H Recombinant Human CD40 Protein, GST-Tagged Wheat Germ GST Inquiry
    Human CD40-174H Recombinant Human CD40, Fc-His tagged Human Cell Fc/His Inquiry
    Human CD40-2221H Recombinant Human CD40 protein, His-tagged HEK293 His Inquiry
    Human CD40-2222H Recombinant Human CD40 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Inquiry
    Human CD40-27810TH Recombinant Human CD40, Fc-tagged Fc Inquiry
    Human CD40-4980H Recombinant Human CD40 Molecule, TNF Receptor Superfamily Member 5 Human N/A Inquiry
    Human CD40-5119H Recombinant Human CD40, His-tagged E.coli His Inquiry
    Human CD40-518H Recombinant Human CD40 molecule, TNF receptor superfamily member 5, His-tagged E.coli His Inquiry
    Mouse Cd40-1715M Recombinant Mouse CD40 Antigen, Fc-His Mammalian cells His Inquiry
    Mouse Cd40-6717M Recombinant Mouse Cd40 protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse Cd40-6892M Recombinant Mouse Cd40, Fc-His tagged Human Cell Fc/His Inquiry
    Mouse Cd40-81M Recombinant Mouse Cd40 protein, His-tagged Insect Cell His Inquiry
    Mouse Cd40-87M Recombinant Mouse Cd40 protein, His-tagged HEK293 His Inquiry
    Rat Cd40-6718R Recombinant Rat Cd40 protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat Cd40-8726R Recombinant Rat Cd40, Fc tagged Human Cell Fc Inquiry
    Rat Cd40-8727R Recombinant Rat Cd40, His tagged Human Cell His Inquiry
    Cynomolgus CD40-23C Recombinant Cynomolgus CD40 Protein, His-tagged HEK293 His Inquiry
    Cynomolgus CD40-85C Recombinant Cynomolgus CD40 protein, His-tagged HEK293 His Inquiry
    Cynomolgus Monkey CD40-8823C Recombinant Cynomolgus CD40, Fc tagged Human Cell Fc Inquiry
    Rhesus Macaque CD40-740R Recombinant Rhesus monkey CD40 Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus macaque CD40-741R Recombinant Rhesus macaque CD40 protein, His-tagged HEK293 His Inquiry
    Rhesus CD40-8824C Recombinant Rhesus CD40 protein, His-tagged HEK293 His Inquiry
    Canine CD40-153C Recombinant Canine CD40, LEVLFQ tagged Human Cell Fc/His Inquiry
    Canine CD40-165C Recombinant Canine CD40, His-tagged Human Cell His Inquiry
    Canine CD40-167C Recombinant Canine CD40, Fc tagged Human Cell Fc Inquiry
    Chicken CD40-6231C Recombinant Chicken CD40 Mammalian Cell His Inquiry
    Zebrafish CD40-7316Z Recombinant Zebrafish CD40 Mammalian Cell His Inquiry
    Human CD40-2617HCL Recombinant Human CD40 cell lysate Human Cell N/A Inquiry
    Mouse CD40-1831MCL Recombinant Mouse CD40 cell lysate Human Cell N/A Inquiry
    Rat CD40-1262RCL Recombinant Rat CD40 cell lysate Human Cell N/A Inquiry
    Cynomolgus Monkey CD40-1254CCL Recombinant Cynomolgus CD40 cell lysate Human Cell N/A Inquiry
    Canine CD40-001CCL Recombinant Canine CD40 cell lysate Human Cell N/A Inquiry
    Human CD40-07H Recombinant Human CD40 Protein, hIgG/His-tagged HEK293 hIgG/His Inquiry
    Dog CD40-153CAF488 Recombinant Canine CD40 Protein, LEVLFQ-tagged, Alexa Fluor 488 conjugated HEK293 LEVLFQ
    Dog CD40-153CAF555 Recombinant Canine CD40 Protein, LEVLFQ-tagged, Alexa Fluor 555 conjugated HEK293 LEVLFQ
    Dog CD40-153CAF647 Recombinant Canine CD40 Protein, LEVLFQ-tagged, Alexa Fluor 647 conjugated HEK293 LEVLFQ
    Dog CD40-153CF Recombinant Canine CD40 Protein, LEVLFQ-tagged, FITC conjugated HEK293 LEVLFQ
    Dog CD40-165CAF488 Recombinant Canine CD40 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Dog CD40-165CAF555 Recombinant Canine CD40 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Dog CD40-165CAF647 Recombinant Canine CD40 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Dog CD40-165CF Recombinant Canine CD40 Protein, His-tagged, FITC conjugated HEK293 His
    Dog CD40-167CAF488 Recombinant Canine CD40 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Dog CD40-167CAF555 Recombinant Canine CD40 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Dog CD40-167CAF647 Recombinant Canine CD40 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Dog CD40-167CF Recombinant Canine CD40 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human CD40-174HAF488 Recombinant Human CD40 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
    Human CD40-174HAF555 Recombinant Human CD40 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
    Human CD40-174HAF647 Recombinant Human CD40 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
    Human CD40-174HF Recombinant Human CD40 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
    Human CD40-2221HAF488 Recombinant Human CD40 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human CD40-2221HAF555 Recombinant Human CD40 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human CD40-2221HAF647 Recombinant Human CD40 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human CD40-2221HF Recombinant Human CD40 Protein, His-tagged, FITC conjugated HEK293 His
    Human CD40-2964HF Recombinant Full Length Human CD40 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human CD40-31H Recombinant Human CD40 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Inquiry
    Human CD40-3237HF Recombinant Full Length Human CD40 Protein, GST-tagged In Vitro Cell Free System Inquiry
    Mouse Cd40-325MAF488 Recombinant Mouse CD40 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Mouse Cd40-325MAF555 Recombinant Mouse CD40 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Mouse Cd40-325MAF647 Recombinant Mouse CD40 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Mouse Cd40-325MF Recombinant Mouse CD40 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human CD40-32H Recombinant Human CD40 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Inquiry
    Human CD40-679H Recombinant Human CD40 Protein, His-tagged HEK293F N-His Inquiry
    Mouse Cd40-6892MAF488 Recombinant Mouse Cd40 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
    Mouse Cd40-6892MAF555 Recombinant Mouse Cd40 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
    Mouse Cd40-6892MAF647 Recombinant Mouse Cd40 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
    Mouse Cd40-6892MF Recombinant Mouse Cd40 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
    Rat Cd40-8726RAF488 Recombinant Rat Cd40 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Rat Cd40-8726RAF555 Recombinant Rat Cd40 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Rat Cd40-8726RAF647 Recombinant Rat Cd40 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Rat Cd40-8726RF Recombinant Rat Cd40 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Rat Cd40-8727RAF488 Recombinant Rat Cd40 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Rat Cd40-8727RAF555 Recombinant Rat Cd40 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Rat Cd40-8727RAF647 Recombinant Rat Cd40 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Rat Cd40-8727RF Recombinant Rat Cd40 Protein, His-tagged, FITC conjugated HEK293 His
    Monkey CD40-8823CAF488 Recombinant Monkey CD40 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Monkey CD40-8823CAF555 Recombinant Monkey CD40 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Monkey CD40-8823CAF647 Recombinant Monkey CD40 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Monkey CD40-8823CF Recombinant Monkey CD40 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Monkey CD40-8824CAF488 Recombinant Monkey CD40 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Monkey CD40-8824CAF555 Recombinant Monkey CD40 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Monkey CD40-8824CAF647 Recombinant Monkey CD40 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Monkey CD40-8824CF Recombinant Monkey CD40 Protein, His-tagged, FITC conjugated HEK293 His
    Mus musculus (Mouse) RFL13008MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 5(Cd40) Protein, His-Tagged E.coli expression system His Inquiry
    Homo sapiens (Human) RFL32571HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 5(Cd40) Protein, His-Tagged E.coli expression system His Inquiry
    Human CAB11500RH Rabbit Anti-Human CD40 Molecule, TNF Receptor Superfamily Member 5 Monoclonal Antibody Rabbit N/A Inquiry
    Human CD40-107HG GMP Recombinant Human CD40 protein, His-tagged HEK293 His Inquiry
    Human CD40-1087H Recombinant Human CD40 Protein (Met1-Arg193), His-tagged, Biotinylated HEK293 His Inquiry
    Human CD40-108HA Recombinant Human CD40 protein, Fc-tagged, APC labeled CHO Fc Inquiry
    Human CD40-108HP Recombinant Human CD40 protein, Fc-tagged, R-PE labeled CHO Fc Inquiry
    Human CD40-371H Recombinant Human CD40 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc Inquiry
    Human CD40-389H Recombinant Human CD40 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc Inquiry
    Human DMAB6033MH Mouse Anti-Human CD40 Monoclonal Antibody Mouse N/A Inquiry
    Mouse CD40-1088M Recombinant Mouse CD40 Protein (Met1-Arg193), HlgG1 Fc-tagged HEK293 HlgG1 Fc Inquiry
    Mouse Cd40-325M Recombinant Mouse CD40 Protein, Fc-tagged HEK293 Fc Inquiry
    Mouse CD40-816M Recombinant Mouse CD40 Protein (Val24-Arg193), His-tagged Yeast His Inquiry
    Rhesus macaque CD40-388R Recombinant Rhesus macaque CD40 protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Canine CD40-928C Recombinant Canine CD40 Protein (Glu21-Ala194), His-tagged Yeast His Inquiry

    CD40 involved in several pathways and played different roles in them. We selected most pathways CD40 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CXCL16; ACVR1BA; TNFRSF25; CXCR4B; TNFSF13; CSF1; CCR8; CSF2; CCL2; IL18
    NF-kappa B signaling pathway GM10591; TRAF5; BCL10; CCL19; MAP3K7IP3; PTGS2; TNFSF11; TNFRSF1A; IKBKG; CARD11
    Cell adhesion molecules (CAMs) CLDN11A; CD34; NRXN2A; NCAM1A; CLDNK; SELPLG; CLDN11; BMA1; HLA-DRB1; MPZ
    Toll-like receptor signaling pathway RAC1; CASP8; MAPK8A; MAP2K4B; LY96; FOS; MAPK8B; IRAK1; TLR1; MAP2K3
    Intestinal i MHC2DAB; ICOSLG; ICOS; IL5; HLA-DPB1; CXCR4B; HLA-DOA; BLB2; HLA-DRB4; HLA-DRB5
    ne network for IgA production CD28; CCL25; HLA-DPA1; HLA-DRB5; TGFB1A; H2-AA; CCL25B; MHC2A; BMA1; CCR10
    Malaria HBB-B1; HBB-B2; CD40LG; IL1B; MET; GYPA; THBS2; HBA2; CD40; SELP
    Toxoplasmosis TNF; HLA-DRB3; Casp3; HSPA1B; HLA-DMB; H2-AA; LDLR; IRAK4; IL12B; ALOX5
    HTLV-I infection FZD7; ATF1; MAP3K14; ELK1; POLE3; TBPL1; TBPL2; BUB3; ANAPC1; WNT3
    Epstein-Barr virus infection IKBKB; HSPA1B; TRAF2; POLR3F; YWHAE; CCNA2; POLR2E; MAPK9; HDAC5; CSNK2B
    Transcriptional misregulation in cancer PAX3; MAX; TSPAN7; ERG; EWSR1; HIST1H3H; BCL2A1; LRP2BP; SP1; H3F3A
    Asthma IL9; HLA-DPB1; HLA-DMB; HLA-DRB4; IL13; HLA-DRB5; FCER1A; CCL11; HLA-DQA1; HLA-DRA
    Autoi H2-AA; IFNA16; HLA-DOA; HLA-DRB5; HLA-DOB; TPO; GZMB; IFNA10; HLA-DRA; CD28
    ne thyroid disease IFNA5; HLA-DRA; HLA-E; IL4; HLA-DQA2; H2-AA; Il2; HLA-DMB; IFNA17; IFNA7
    Systemic lupus erythematosus HIST1H2BF; HIST1H2AM; H2AFJ; HIST1H2BO; H3F3C; ACTN4; ACTN3; HIST1H2AJ; HIST1H2BK; HLA-DRB1
    Allograft rejection HLA-DOB; PRF1; Il2; HLA-F; MICA; HLA-G; HLA-DRB5; HLA-DOA; CD80; IFNG
    Primary i TAP1; AIRE; IKBKG; CD79A; DCLRE1C; TNFRSF13B; RFX5; CD19; CD3D; BLNK
    nodeficiency RFX5; TAP2; BLNK; Cd79a, Cd79b; CD3E; RFXAP; ORAI1; CD4; RAG1; CD8B1
    Viral myocarditis ITGB2L; HLA-C; SGCG; CD80; HLA-G; H2-AB1; HLA-DRB1; FYN; CD28; CCND1

    CD40 has several biochemical functions, for example, antigen binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD40 itself. We selected most functions CD40 had, and list some proteins which have the same functions with CD40. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding Ighg2a; IgG3; KIR2DL3; Ighg2b; SLAMF1; IGLL1; IGLC2; IGJ; IL7R; PPP2R1A
    enzyme binding PHKG1; APOA1; TUT1; TSPAN10; PTPLA; KPNB1; PPP3CB; CASC3; CYP3A4; PARK7
    protein binding EPC1; BNIP3L; SZT2; GSTK1; IL17RA; NPL; HSF2; KCNN4; SYT7; FGFR3
    receptor activity FPR1; TLR2; CADM1B; CLEC4M; ANTXR2; KLRG1; VMN1R50; GUCY1A3; ABP1; PAQR5A
    signal transducer activity TAAR14G; PRKCE; ADRB3A; OPN1SW1; TRAF5; TAS2R106; MUL1A; APLNRB; RGS9; OPN4.1
    tumor necrosis factor-activated receptor activity EDA2R; TNFRSF10D; TNFRSF4; TNFRSFA; Tnfrsf26; TNFRSF18; NRADD; TNFRSF21; TNFRSF10A; HDR
    ubiquitin protein ligase binding USP2; BRCA1; ZFP746; PACRG; H2-AB1; SMAD2; SNX9; TMEM173; TRAF6; RPA3

    CD40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD40 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD40.

    TRAF2; TRAF6; TRAF3; 21362046; SGK1; OGT; KATNA1; TXN; PCMT1; FBL; CALR

    Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
    Cozza, EM; Cooper, TK; et al. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:325-336(2015).

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