CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B -cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. The CD40 gene is localized to the long arm of chromosome 20, bands q12-q13.2. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
Synonyms
CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CD_antigen=CD40; CD40 antigen; Dacetuzumab; 880486-59-9; Teneliximab; 299423-37-3;
CD40 involved in several pathways and played different roles in them. We selected most pathways CD40 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CD40 has several biochemical functions, for example, antigen binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD40 itself. We selected most functions CD40 had, and list some proteins which have the same functions with CD40. You can find most of the proteins on our site.
CD40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD40 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD40.
Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
Cozza, EM; Cooper, TK; et al. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:325-336(2015).
Its utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.
08/11/2021
The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.
10/07/2018
CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.
Can CD40-targeted therapies be used in the treatment of infectious diseases?
05/31/2022
CD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.
Are there any approved drugs targeting CD40 for clinical use?
05/07/2021
As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.
Can CD40-targeted therapies be used in combination with other cancer treatments?
04/24/2019
Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.
What are the potential side effects of CD40-targeted therapies in cancer treatment?
09/25/2018
Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.
Are there ongoing clinical trials exploring CD40-targeted therapies for atherosclerosis?
04/25/2017
Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.
