Active Recombinant Mouse Interleukin 1 Receptor, Type I, His-tagged
| Cat.No. : | Il1r1-5652M |
| Product Overview : | RecombinantMouse Il1r1 protein was expressed in Murine myeloma cellline.Asp22-Arg338 (Ala158Val), with a C-terminal 6-His tag. |
- Specification
- Gene Information
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| Cat. No. : | Il1r1-5652M |
| Description : | Il1r1 isa member of the IL-1 R/TLR superfamily. Members of this superfamily have a characteristicToll-IL-1 R (TIR) domain in their cytoplasmic region. This superfamily can befurther divided into three subgroups based on extracellular region analogies.Il1r1 belongs to Subgroup 1 which is characterized by the presence of atleast one immunoglobulin-like domain. Mouse Il1r1 is a 70 kDa type I transmembraneglycoprotein that is synthesized as a 574 amino acid (aa) precursor. Theprecursor contains a 21 aa signal sequence, a 317 aa extracellular region, a21 aa transmembrane segment, and a 215 aa cytoplasmic domain. |
| Source : | Mammalian cells |
| Form : | Lyophilizedfrom a 0.2 um filtered solution in PBS with BSA as a carrier protein. |
| N-terminalSequence : | Asp22 |
| MolecularWeight : | 36.8 kDa |
| Activity : | Measuredby its binding ability in a functional ELISA. Immobilized rmIL-1F5, rmIL-1F6,or rmIL-1F8 at 1 μg/mL (100 μL/well) can bind rm Il1r1/his witha linear range of 0.078-5 μg/mL. |
| Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
| SDS-PAGE : | 55-68kDa, reducing conditions. |
| Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution : | 100 μg/mLin sterile PBS containing at least 0.1% human or bovine serum albumin |
| Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution. |
| Gene Name : | Il1r1 interleukin 1 receptor,type I [ Mus musculus ] |
| Official Symbol : | Il1r1 |
| Synonyms : | Il1r1; interleukin 1receptor, type I; IL-iR; CD121a;CD121b; Il1r-1; interleukin-1 receptor type 1; p80; IL-1R-1; IL-1RT1;IL-1RT-1; IL-1R-alpha; IL-1 receptor alpha chain; interleukin-1 receptoralpha; interleukin-1 receptor type I; CD121 antigen-like family member A |
| Gene ID : | 16177 |
| mRNA Refseq : | NM_001123382 |
| Protein Refseq : | NP_001116854 |
| UniProt ID : | Q9ERS7 |
| Chromosome Location : | 1 |
| Pathway : | Amoebiasis;Apoptosis; Cytokine-cytokine receptor interaction; HTLV-I infection;Hematopoietic cell lineage; Hypertrophy Model; IL-1 Signaling Pathway; MAPKsignaling pathway; Osteoclast differentiation |
| Function : | interleukin-1receptor activity; interleukin-1, Type I, activating receptor activity;ionotropic glutamate receptor binding; platelet-derived growth factorreceptor binding; protease binding; protein binding; receptor activity;signal transducer activity; transmembrane signaling receptor activity |
Products Types
| ◆ Recombinant Protein | ||
| IL1R1-164H | Recombinant Human IL1R1 Protein (ECD), His-tagged(C-ter) | +Inquiry |
| IL1R1-02H | Active Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged | +Inquiry |
| IL1R1-064H | Recombinant Human IL1R1 Protein, C-His-tagged | +Inquiry |
| IL1R1-3147H | Recombinant Human IL1R1 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Il1r1-10581M | Recombinant Mouse Il1r1 Protein, His (Fc)-Avi-tagged | +Inquiry |
| ◆ Lysates | ||
| IL1R1-1935RCL | Recombinant Rat IL1R1 cell lysate | +Inquiry |
| IL1R1-1120HCL | Recombinant Human IL1R1 cell lysate | +Inquiry |
| IL1R1-1787MCL | Recombinant Mouse IL1R1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionLive-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
Customer Reviews (3)
Write a reviewHigh stability. -
Suitable for ELISA. -
Effective in signaling studies. -
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