Active Recombinant Mouse Interleukin 1 Receptor, Type I, His-tagged

Cat.No. : Il1r1-5652M
Product Overview : RecombinantMouse Il1r1 protein was expressed in Murine myeloma cellline.Asp22-Arg338 (Ala158Val), with a C-terminal 6-His tag.
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Cat. No. : Il1r1-5652M
Description : Il1r1 isa member of the IL-1 R/TLR superfamily. Members of this superfamily have a characteristicToll-IL-1 R (TIR) domain in their cytoplasmic region. This superfamily can befurther divided into three subgroups based on extracellular region analogies.Il1r1 belongs to Subgroup 1 which is characterized by the presence of atleast one immunoglobulin-like domain. Mouse Il1r1 is a 70 kDa type I transmembraneglycoprotein that is synthesized as a 574 amino acid (aa) precursor. Theprecursor contains a 21 aa signal sequence, a 317 aa extracellular region, a21 aa transmembrane segment, and a 215 aa cytoplasmic domain.
Source : Mammalian cells
Form : Lyophilizedfrom a 0.2 um filtered solution in PBS with BSA as a carrier protein.
N-terminalSequence : Asp22
MolecularWeight : 36.8 kDa
Activity : Measuredby its binding ability in a functional ELISA. Immobilized rmIL-1F5, rmIL-1F6,or rmIL-1F8 at 1 μg/mL (100 μL/well) can bind rm Il1r1/his witha linear range of 0.078-5 μg/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 55-68kDa, reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 100 μg/mLin sterile PBS containing at least 0.1% human or bovine serum albumin
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Il1r1 interleukin 1 receptor,type I [ Mus musculus ]
Official Symbol : Il1r1
Synonyms : Il1r1; interleukin 1receptor, type I; IL-iR; CD121a;CD121b; Il1r-1; interleukin-1 receptor type 1; p80; IL-1R-1; IL-1RT1;IL-1RT-1; IL-1R-alpha; IL-1 receptor alpha chain; interleukin-1 receptoralpha; interleukin-1 receptor type I; CD121 antigen-like family member A
Gene ID : 16177
mRNA Refseq : NM_001123382
Protein Refseq : NP_001116854
UniProt ID : Q9ERS7
Chromosome Location : 1
Pathway : Amoebiasis;Apoptosis; Cytokine-cytokine receptor interaction; HTLV-I infection;Hematopoietic cell lineage; Hypertrophy Model; IL-1 Signaling Pathway; MAPKsignaling pathway; Osteoclast differentiation
Function : interleukin-1receptor activity; interleukin-1, Type I, activating receptor activity;ionotropic glutamate receptor binding; platelet-derived growth factorreceptor binding; protease binding; protein binding; receptor activity;signal transducer activity; transmembrane signaling receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    High stability.


      Suitable for ELISA.


        Effective in signaling studies.

        Q&As (10)

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        How does the cellular localization of IL1R1 influence its responsiveness to ligands, and how can live-cell imaging techniques track its dynamic movement on the cell surface? 10/01/2022

        Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.

        How can advanced computational modeling and molecular dynamics simulations predict the allosteric changes in IL1R1's intracellular domain upon ligand binding, offering insights into its downstream signaling cascade? 04/19/2022

        Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.

        What are the mechanisms underlying IL1R1's dimerization and oligomerization, and how can FRET and cross-linking assays provide insights into its multimeric assembly? 12/26/2020

        FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.

        How does IL1R1's endocytosis and recycling affect its signaling duration, and how can confocal microscopy and flow cytometry unveil its intracellular trafficking patterns? 12/25/2020

        Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.

        What are the intricate molecular details of IL1R1's recruitment of MyD88 and other adapter proteins upon ligand binding, and how can co-immunoprecipitation assays reveal these interactions? 07/25/2020

        Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.

        How does the interaction between IL1R1 and accessory proteins like IL1RAP influence its ligand binding and intracellular signaling, and how can mutagenesis studies dissect these interfaces? 04/13/2020

        Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.

        How do the structural dynamics of IL1R1's extracellular domains modulate its binding to various ligands, and how can cryo-electron microscopy unveil these conformational changes? 02/22/2020

        Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.

        What are the intricate crosstalk mechanisms between IL1R1 and other receptors in cell signaling networks, and how can proteomics-based studies dissect these interconnected pathways? 01/17/2020

        Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.

        What are the complex regulatory mechanisms governing IL1R1's expression and alternative splicing, and how can CRISPR-based approaches shed light on the functional consequences of these variations? 09/09/2018

        CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.

        In what ways does IL1R1's post-translational modification landscape impact its downstream signaling, and how can phosphoproteomics offer a comprehensive view of its phosphorylation events? 09/17/2017

        Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.

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