• Official Full Name

    interleukin 1 receptor, type I

  • Background

    Tumor Necrosis Factor Receptor Type I (TNFRI); is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-alpha and TNF-beta; (also known as LT-alpha );. The subsequen
  • Synonyms

    IL1R1; interleukin 1 receptor, type I; IL1R, IL1RA; interleukin-1 receptor type 1; CD121A; D2S1473; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Therapeutic Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Spodoptera Frugiperda
    • Tag :
    • C
    • His
    • DDDDK
    • Fc
    • FC
    • hFc
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|T7
    • SUMO
    • Myc
    • N/A
    • N
    • GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken IL1R1-7034C Recombinant Chicken IL1R1 Mammalian Cell His
    Cynomolgus IL1R1-148C Active Recombinant Cynomolgus IL1R1, Fc tagged HEK293 Fc
    Cynomolgus IL1R1-149C Active Recombinant Cynomolgus IL1R1, His tagged HEK293 His
    Cynomolgus Monkey IL1R1-945CCL Recombinant Cynomolgus IL1R1 cell lysate Human Cell N/A
    Human IL1R1-772H Active Recombinant Human IL1R1, His tagged HEK293 His
    Human IL1R1-251H Recombinant Human IL1R1 Mammalian Cell His
    Human IL1R1-527H Recombinant Human IL1R1, DDDDK-tagged HEK293 DDDDK
    Human IL1R1&IL1RAcP-P01H Recombinant Human IL1R1/IL1RAcP, Fc-tagged therapeutic protein Fc
    Human IL1R1-14174H Recombinant Human IL1R1, His-tagged E.coli His
    Human IL1R1-1120HCL Recombinant Human IL1R1 cell lysate Human Cell N/A
    Human IL1R1-299H Active Recombinant Human IL1R1, Fc-tagged HEK293 Fc
    Human IL1R1-771H Recombinant Human IL1R1 protein, hFc-tagged HEK293 hFc
    Human IL1R1-3011H Active Recombinant Human IL1R1, MIgG2a Fc-tagged CHO Fc
    Human IL1R1-552H Recombinant Human IL1R1 protein, His-tagged E.coli His
    Human IL1R1-1640H Recombinant Human Interleukin 1 Receptor, Type I Mammalian cells N/A
    Human IL1R1-3012H Active Recombinant Human IL1R1, HIgG1 Fc-tagged CHO Fc
    Human IL1R1-627H Active Recombinant Human IL1R1, Fc-tagged, Biotinylated Human Cell Fc
    Human IL1R1-214H Active Recombinant Human IL1R1 Protein HEK293 N/A
    Human IL1R1-02H Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged Insect Cell C-His
    Human IL1R1-286H Recombinant Human Interleukin 1 Receptor, Type I, His-tagged E.coli His
    Human IL1R1-3147H-B Recombinant Human IL1R1 Protein Pre-coupled Magnetic Beads HEK293
    Human IL1R1-2379H Recombinant Human IL1R1 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc
    Human IL1R1-0310H Recombinant Human IL1R1 protein HEK293 N/A
    Human IL1R1-368H Recombinant Human IL1R1 Protein, His-tagged Insect Cell His
    Human IL1R1-1214H Recombinant Human IL1R1 Protein (Asp21-Ile109), N-GST tagged E.coli N-GST
    Human IL1R1-064H Recombinant Human IL1R1 Protein, C-His-tagged E.coli C-His
    Human IL1R1-879H Recombinant Human IL1R1 protein, His-tagged E.coli His
    Human IL1R1-3147H Recombinant Human IL1R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL1R1-164H Recombinant Human IL1R1 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter)
    Mouse Il1r1-5188M Recombinant Mouse Il1r1, His tagged Human Cell His
    Mouse Il1r1-881M Recombinant Mouse Il1r1 protein, His & T7-tagged E.coli His/T7
    Mouse Il1r1-10581M-B Recombinant Mouse Il1r1 Protein Pre-coupled Magnetic Beads HEK293
    Mouse IL1R1-1787MCL Recombinant Mouse IL1R1 cell lysate Human Cell N/A
    Mouse Il1r1-1753M Recombinant Mouse Interleukin 1 Receptor, Type I Mammalian cells N/A
    Mouse Il1r1-5653M Active Recombinant Mouse Interleukin 1 Receptor, Type I, Fc-tagged Mammalian cells Fc
    Mouse Il1r1-10581M Recombinant Mouse Il1r1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il1r1-5651M Active Recombinant Mouse Interleukin 1 Receptor, Type I, Fc-tagged Spodoptera Frugiperda Fc
    Mouse IL1R1-917M Active Recombinant Mouse IL1R1 Protein, Fc-tagged HEK293 Fc
    Mouse Il1r1-5652M Active Recombinant Mouse Interleukin 1 Receptor, Type I, His-tagged Mammalian cells His
    Rat IL1R1-1935RCL Recombinant Rat IL1R1 cell lysate Human Cell N/A
    Rat Il1r1-882R Recombinant Rat Il1r1 protein, His-tagged E.coli His
    Rat Il1r1-4088R Recombinant Rat Il1r1, Fc-His tagged HEK293 FC/His
    Rat Il1r1-883R Recombinant Rat Il1r1 protein, His-tagged E.coli His
    Rat Il1r1-4089R Active Recombinant Rat Il1r1, His tagged HEK293 His
    Rat Il1r1-884R Recombinant Rat Il1r1 protein, His-tagged E.coli His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL1R1 Related Articles
    • IL1R1 Related Gene Family
    • IL1R1 Related Research Area
    • IL1R1 Related Signal Pathway

    IL1R1 involved in several pathways and played different roles in them. We selected most pathways IL1R1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayFGF1A;RPS6KA5;FAS;RPS6KA6;HSC70;SRFA;C11orf52;HSPA1B;MYCB
    Cytokine-cytokine receptor interactionIL17RB;FASLG;IL10RB;TGFBR2;CNTF;IFNL3;CXCL14;CXCR1;CCL25B
    NF-kappa B signaling pathwayLCK;LYN;IL1B;PLCG2;CARD11;LAT;CCL21;UBE2I;MAP3K7IP3
    Osteoclast differentiationNFKBIA;FOSL1;PPP3CA;TNFRSF1A;MAPK3;TREM2;MAPK10;MAPK9;LILRA2
    Hematopoietic cell lineageCD4;IL5RA;CD1A;Il4ra;CD8B;IL1R1;CD37;ITGA2;IL11RA2
    Inflammatory mediator regulation of TRP channelsTRPV4;MAP2K3;PLCB2;MAPK8;CALM2;CYP2C39;PTGER2;CALM1;CALM3

    IL1R1 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, ionotropic glutamate receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1R1 itself. We selected most functions IL1R1 had, and list some proteins which have the same functions with IL1R1. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-1 receptor activityIL1RAP;IL1RAPL2;IL18R1;IL1RAPL1A;IL1R2;IL1RL2;IL1R1;IL1RL1
    interleukin-1, Type I, activating receptor activityIL1RL2;IL1R1
    ionotropic glutamate receptor bindingSHANK2;SHANK1;DLG2;CACNG2;GNAS;NETO1;DLG1L;IL1R1;DLG1
    platelet-derived growth factor receptor bindingPDGFAA;PDGFB;PDGFRA;FIGF;TYMP;Pdgfa&Pdgfb;ITGB3;PTEN;PDGFC
    protease bindingMALT1;BCL2;VWF;TP53;UBC;RFFL;F3;CNTNAP2;TIMP4
    signal transducer activityGNA13;Fzd4;TAS2R106;TFG;PTGER1B;PTH1RA;OLFR958;STAT4;LITAF
    transmembrane signaling receptor activityFZD8B;ANTXR1;TLR2;SORL1;KLRC3;CD97;CLEC4A;TNFRSF10D;CLEC2H

    IL1R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1R1.


    Suwara, MI; Green, NJ; et al. IL-1 alpha released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. MUCOSAL IMMUNOLOGY 7:684-693(2014).
    Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How does the cellular localization of IL1R1 influence its responsiveness to ligands, and how can live-cell imaging techniques track its dynamic movement on the cell surface? 10/01/2022

    Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.

    How can advanced computational modeling and molecular dynamics simulations predict the allosteric changes in IL1R1's intracellular domain upon ligand binding, offering insights into its downstream signaling cascade? 04/19/2022

    Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.

    What are the mechanisms underlying IL1R1's dimerization and oligomerization, and how can FRET and cross-linking assays provide insights into its multimeric assembly? 12/26/2020

    FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.

    How does IL1R1's endocytosis and recycling affect its signaling duration, and how can confocal microscopy and flow cytometry unveil its intracellular trafficking patterns? 12/25/2020

    Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.

    What are the intricate molecular details of IL1R1's recruitment of MyD88 and other adapter proteins upon ligand binding, and how can co-immunoprecipitation assays reveal these interactions? 07/25/2020

    Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.

    How does the interaction between IL1R1 and accessory proteins like IL1RAP influence its ligand binding and intracellular signaling, and how can mutagenesis studies dissect these interfaces? 04/13/2020

    Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.

    How do the structural dynamics of IL1R1's extracellular domains modulate its binding to various ligands, and how can cryo-electron microscopy unveil these conformational changes? 02/22/2020

    Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.

    What are the intricate crosstalk mechanisms between IL1R1 and other receptors in cell signaling networks, and how can proteomics-based studies dissect these interconnected pathways? 01/17/2020

    Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.

    What are the complex regulatory mechanisms governing IL1R1's expression and alternative splicing, and how can CRISPR-based approaches shed light on the functional consequences of these variations? 09/09/2018

    CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.

    In what ways does IL1R1's post-translational modification landscape impact its downstream signaling, and how can phosphoproteomics offer a comprehensive view of its phosphorylation events? 09/17/2017

    Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.

    Customer Reviews (3)

    Write a review

      High stability. -


        Suitable for ELISA. -


          Effective in signaling studies. -

          Ask a Question for All IL1R1 Products

          Required fields are marked with *

          My Review for All IL1R1 Products

          Required fields are marked with *


          Stay Updated on the
          Latest Bioscience Trends

          Copyright © 2023 Creative BioMart. All Rights Reserved.

          Terms and Conditions        Privacy Policy