IL1R1
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Official Full Name
interleukin 1 receptor, type I
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Overview
Tumor Necrosis Factor Receptor Type I (TNFRI); is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-alpha and TNF-beta; (also known as LT-alpha );. The subsequen -
Synonyms
IL1R1; interleukin 1 receptor, type I; IL1R, IL1RA; interleukin-1 receptor type 1; CD121A; D2S1473; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family;
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- Involved Pathway
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- IL1R1 Related Signal Pathway
IL1R1 involved in several pathways and played different roles in them. We selected most pathways IL1R1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | GADD45BA;NTRK2B;PAK2A;RASGRF2B;FGF19;RPS6KA3;CACNB4A;RAC3A;NFKB1 |
| Cytokine-cytokine receptor interaction | RNF207B;CD27;BMPR2;CCL4L1;CXCL6;IL1R1;XCL2;OSM;TGFBR1A |
| NF-kappa B signaling pathway | CCL4L2;ICAM1;RELA;DDX58;CD40;TNFRSF13C;ZAP70;CCL4L1;LYN |
| Apoptosis | ATM;DNM1L;PRKACAB;CAPN2L;PRKAR2AA;IRF2;BIRC7;HIST1H1E;TNF |
| Osteoclast differentiation | NCF1;TNFRSF11A;TEC;MAPK11;GRB2;PIK3R5;LILRB2;TNFRSF1A;PIK3R3 |
| Hematopoietic cell lineage | CD36;IL3RA;CD3G;HLA-DRB1;CSF1;FCER2;IL5RA;IL5;CD38 |
| Inflammatory mediator regulation of TRP channels | CYP4A10;MAPK13;ALOX12E;MAP2K3;PIK3CA;PLA2G4A;PRKCE;HRH1;PLCB2 |
| Amoebiasis | GNA15;SERPINB6B;IL12B;LAMB2;COL4A3;COL24A1;PIK3R5;GNAL;ACTN3 |
| HTLV-I infection | FZD2;MYBL1;GSK3B;HLA-DQB1;PIK3CG;PIK3R3;KRAS;VDAC1;WNT1 |
IL1R1 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, ionotropic glutamate receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1R1 itself. We selected most functions IL1R1 had, and list some proteins which have the same functions with IL1R1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-1 receptor activity | IL1RAPL2;IL1RAPL1A;IL1R2;IL1R1;IL1RL2;IL1RAP;IL18R1;IL1RL1 |
| interleukin-1, Type I, activating receptor activity | IL1RL2;IL1R1 |
| ionotropic glutamate receptor binding | FUS;NETO1;DLG4B;CACNG2;DLG1L;SHANK3;GNAS;DLG4;CANX |
| platelet-derived growth factor receptor binding | FIGF;PDGFAA;IL1R1;PDGFD;PTPRJ;PDGFB;PDGFRB;PDGFAB;ITGB3 |
| protease binding | HSPD1;SERPINE1;FN1;INS1;MALT1;CNTNAP2;SRI;TIMP4;SERPINB6 |
| protein binding | FRS3;NCKIPSD;CTNNBL1;TSSK1;ESRRA;POLB;SLPI;HPSE;RTN4RL2A |
| signal transducer activity | GRM6B;OPN1MW1;TAAR14E;JUP;LPAR6;ERG;TAS2R117;GPR184;OLFCW1 |
| transmembrane signaling receptor activity | CLDN3;LGR4;GABRQ;KLRC3;GPR133;IL4R.1;MRC1;EBP;DNER |
IL1R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1R1.
TRAF6; IL1B; IL1RN; TICAM2; IL1RAP; MAP3K14
Gene Family
Research Area
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Customer Reviews (3)
Write a reviewHigh stability.
Suitable for ELISA.
Effective in signaling studies.
Q&As (10)
Ask a questionLive-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
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