IL1R1

  • Official Full Name

    interleukin 1 receptor, type I

  • Overview

    Tumor Necrosis Factor Receptor Type I (TNFRI); is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-alpha and TNF-beta; (also known as LT-alpha );. The subsequen
  • Synonyms

    IL1R1; interleukin 1 receptor, type I; IL1R, IL1RA; interleukin-1 receptor type 1; CD121A; D2S1473; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Therapeutic Proteins
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In vitro E. coli expression system
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Spodoptera Frugiperda
  • C
  • Fc
  • His
  • DDDDK
  • FC
  • Flag
  • hFc
  • His (Fc)
  • Avi
  • Myc
  • His(C
  • ter)
  • His|T7
  • SUMO
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL1R1-214H Active Recombinant Human IL1R1 Protein HEK293 N/A
Human IL1R1-772H Active Recombinant Human IL1R1, His tagged HEK293 His Met 1-Thr 332
Human IL1R1-3012H Active Recombinant Human IL1R1, HIgG1 Fc-tagged CHO Fc
Human IL1R1-299H Active Recombinant Human IL1R1, Fc-tagged HEK293 Fc
Human IL1R1-3011H Active Recombinant Human IL1R1, MIgG2a Fc-tagged CHO Fc
Human IL1R1-627H Active Recombinant Human IL1R1, Fc-tagged, Biotinylated Human Cell Fc
Human IL1R1-251H Recombinant Human IL1R1 Mammalian Cell His
Human IL1R1-1640H Recombinant Human Interleukin 1 Receptor, Type I Mammalian cells N/A
Human IL1R1-286H Recombinant Human Interleukin 1 Receptor, Type I, His-tagged E.coli His
Human IL1R1-14174H Recombinant Human IL1R1, His-tagged E.coli His 224-569a.a.
Human IL1R1-552H Recombinant Human IL1R1 protein, His-tagged E.coli His Asp21~Ile109
Human IL1R1-527H Active Recombinant Human IL1R1, DDDDK-tagged HEK293 DDDDK Met1-Thr332
Human IL1R1-368H Recombinant Human IL1R1 Protein, His-tagged Insect Cell His
Human IL1R1-879H Recombinant Human IL1R1 protein, His-tagged E.coli His Pro226~His318 (Accession # P14778)
Human IL1R1-771H Active Recombinant Human IL1R1 protein, hFc-tagged HEK293 hFc Met1-Thr332
Human IL1R1-1120HCL Recombinant Human IL1R1 cell lysate Human Cell N/A
Human IL1R1-3147H-B Recombinant Human IL1R1 Protein Pre-coupled Magnetic Beads HEK293
Human IL1R1-164H Recombinant Human IL1R1 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Asp21-Thr332
Human IL1R1-9818HFL Recombinant Full Length Human IL1R1, Flag-tagged Mamanlian cells Flag
Human IL1R1-2379H Recombinant Human IL1R1 Full Length Transmembrane protein, His-SUMO & Myc-tagged In vitro E. coli expression system His-SUMO & Myc 18-569aa
Human IL1R1-0310H Active Recombinant Human IL1R1 protein HEK293 N/A Met1-Thr332
Human IL1R1&IL1RAcP-P01H Recombinant Human IL1R1/IL1RAcP, Fc-tagged therapeutic protein Fc
Human IL1R1-02H Active Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged Insect Cell C-His 19-328
Human IL1R1-064H Recombinant Human IL1R1 Protein, C-His-tagged E.coli C-His
Human IL1R1-1214H Recombinant Human IL1R1 Protein (Asp21-Ile109), N-GST tagged E.coli N-GST Asp21-Ile109
Human IL1R1-3147H Recombinant Human IL1R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL1R1-4266H Recombinant Human IL1R1 Protein (Met1-Thr332), C-Fc tagged Mammalian cells C-Fc Met1-Thr332
Mouse IL1R1-917M Active Recombinant Mouse IL1R1 Protein, Fc-tagged HEK293 Fc
Mouse Il1r1-5653M Active Recombinant Mouse Interleukin 1 Receptor, Type I, Fc-tagged Mammalian cells Fc
Mouse Il1r1-5651M Active Recombinant Mouse Interleukin 1 Receptor, Type I, Fc-tagged Spodoptera Frugiperda Fc
Mouse Il1r1-5652M Active Recombinant Mouse Interleukin 1 Receptor, Type I, His-tagged Mammalian cells His
Mouse Il1r1-5188M Recombinant Mouse IL1R1 protein(Met1-Lys338), His-tagged HEK293 C-His Met1-Lys338
Mouse Il1r1-881M Recombinant Mouse Il1r1 protein, His & T7-tagged E.coli His/T7 Leu20~Lys338 (Accession # P13504)
Mouse Il1r1-1753M Recombinant Mouse Interleukin 1 Receptor, Type I Mammalian cells N/A
Mouse IL1R1-1787MCL Recombinant Mouse IL1R1 cell lysate Human Cell N/A
Mouse Il1r1-10581M-B Recombinant Mouse Il1r1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Il1r1-5701M Recombinant Mouse Il1r1 Protein (Leu20-Lys338), C-Fc tagged Mammalian cells C-Fc Leu20-Lys338
Mouse Il1r1-10581M Recombinant Mouse Il1r1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Il1r1-4089R Active Recombinant Rat Il1r1, His tagged HEK293 His Met 1-Lys 352
Rat Il1r1-882R Recombinant Rat Il1r1 protein, His-tagged E.coli His Thr119~Tyr217 (Accession # Q02955)
Rat Il1r1-4088R Recombinant Rat Il1r1, Fc-His tagged HEK293 FC/His Met 1-Lys 352
Rat Il1r1-883R Recombinant Rat Il1r1 protein, His-tagged E.coli His Val226~Lys352 (Accession # M95578)
Rat Il1r1-884R Recombinant Rat Il1r1 protein, His-tagged E.coli His Asp386~Tyr553 (Accession # Q02955)
Rat IL1R1-1935RCL Recombinant Rat IL1R1 cell lysate Human Cell N/A
Cynomolgus IL1R1-148C Active Recombinant Cynomolgus IL1R1, Fc tagged HEK293 Fc Met1-Thr332
Cynomolgus IL1R1-149C Active Recombinant Cynomolgus IL1R1, His tagged HEK293 His Met1-Thr332
Cynomolgus Monkey IL1R1-945CCL Recombinant Cynomolgus IL1R1 cell lysate Human Cell N/A
Homo sapiens (Human) RFL30877HF Recombinant Full Length Human Interleukin-1 Receptor Type 1(Il1R1) Protein, His&Myc-Tagged E.coli expression system His&Myc Full Length of Mature Protein (18-569aa)
Mus musculus (Mouse) RFL7442MF Recombinant Full Length Mouse Interleukin-1 Receptor Type 1(Il1R1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-576)
Chicken IL1R1-7034C Recombinant Chicken IL1R1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IL1R1 Related Signal Pathway

IL1R1 involved in several pathways and played different roles in them. We selected most pathways IL1R1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF17;FGF19;MAPK8;PRKCG;SOS1;TP53;CACNA1C;CACNG4;PRKCBA
Cytokine-cytokine receptor interactionPDGFAB;IL23R;IL11;IL6;IL24;CRLF2;TGFBR1A;XCR1;TNFRSF10B
NF-kappa B signaling pathwayCCL21;CCL21B;IKBKB;TNFRSF11A;GADD45B;BCL2A1A;TICAM2;RIPK1;IL1B
ApoptosisIL1RAP;SPNA2;CASP7;TNFRSF10B;GZME;PRKAR2AB;FADD;IRAK3;DCC
Osteoclast differentiationMAP2K6;LILRA5;IFNGR1;NCF2;LILRB5;TEC;LILRA1;SYK;IL1A
Hematopoietic cell lineageGP5;IL1R1;FLT3;CD1E, B2M;ITGA2B;CD59;IL4R;TNF;ANPEP
Inflammatory mediator regulation of TRP channelsCALM3;PLA2G4C;ALOX12;PTGER2;CYP2C37;PRKCG;TRPM8;PIK3CA;IL1RAP
AmoebiasisSERPINB2;IL1R2;SERPINB10;IL12A;PIK3R3;TNF;RAB5C;ACTN4;IL-8
HTLV-I infectionPIK3CA;POLD2;TGFB3;H2-AA;TNFRSF13C;FOS;MAPK8;ZFP36;IL2RG

IL1R1 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, ionotropic glutamate receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1R1 itself. We selected most functions IL1R1 had, and list some proteins which have the same functions with IL1R1. You can find most of the proteins on our site.

Function Related Protein
interleukin-1 receptor activityIL1RAPL1A;IL18R1;IL1R1;IL1R2;IL1RAPL2;IL1RAP;IL1RL1;IL1RL2
interleukin-1, Type I, activating receptor activityIL1RL2;IL1R1
ionotropic glutamate receptor bindingDLG4B;DLG1;DRD2;CANX;SHANK3;GNAS;RAB4A;CACNG2;SHANK1
platelet-derived growth factor receptor bindingPDGFC;PDGFRB;PDGFAB;TYMP;PDGFD;Pdgfa&Pdgfb;FIGF;ITGA5;VEGFA
protease bindingSERPINA5;CFLAR;LDLR;NFRKB;ADAMTSL4;HSPD1;A2M;CRADD;COMP
protein bindingTMEM67;EZH2;HENMT1;TNFAIP8;SEPT2;GNG5;PPP1R16A;KIR2DL4;METTL15
signal transducer activityOPN1MW4;OLFCH1;VMN1R43;TAS2R124;TAAR14L;SECTM1;GNB1A;PLCB3;LPAR2A
transmembrane signaling receptor activityFZD8B;KLRC2;KLRC3;TLR2;PTH1RA;DNER;NPR2;CD247;ADCYAP1R1A

IL1R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1R1.

TRAF6; IL1B; IL1RN; TICAM2; IL1RAP; MAP3K14

Gene Family

IL

Research Area

Related articles

Suwara, MI; Green, NJ; et al. IL-1 alpha released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. MUCOSAL IMMUNOLOGY 7:684-693(2014).
Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
  • Q&As
  • Reviews

Q&As (10)

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How does the cellular localization of IL1R1 influence its responsiveness to ligands, and how can live-cell imaging techniques track its dynamic movement on the cell surface? 10/01/2022

Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.

How can advanced computational modeling and molecular dynamics simulations predict the allosteric changes in IL1R1's intracellular domain upon ligand binding, offering insights into its downstream signaling cascade? 04/19/2022

Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.

What are the mechanisms underlying IL1R1's dimerization and oligomerization, and how can FRET and cross-linking assays provide insights into its multimeric assembly? 12/26/2020

FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.

How does IL1R1's endocytosis and recycling affect its signaling duration, and how can confocal microscopy and flow cytometry unveil its intracellular trafficking patterns? 12/25/2020

Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.

What are the intricate molecular details of IL1R1's recruitment of MyD88 and other adapter proteins upon ligand binding, and how can co-immunoprecipitation assays reveal these interactions? 07/25/2020

Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.

How does the interaction between IL1R1 and accessory proteins like IL1RAP influence its ligand binding and intracellular signaling, and how can mutagenesis studies dissect these interfaces? 04/13/2020

Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.

How do the structural dynamics of IL1R1's extracellular domains modulate its binding to various ligands, and how can cryo-electron microscopy unveil these conformational changes? 02/22/2020

Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.

What are the intricate crosstalk mechanisms between IL1R1 and other receptors in cell signaling networks, and how can proteomics-based studies dissect these interconnected pathways? 01/17/2020

Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.

What are the complex regulatory mechanisms governing IL1R1's expression and alternative splicing, and how can CRISPR-based approaches shed light on the functional consequences of these variations? 09/09/2018

CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.

In what ways does IL1R1's post-translational modification landscape impact its downstream signaling, and how can phosphoproteomics offer a comprehensive view of its phosphorylation events? 09/17/2017

Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.

Customer Reviews (3)

Write a review
Reviews
07/14/2022

    High stability.

    06/07/2017

      Suitable for ELISA.

      04/19/2017

        Effective in signaling studies.

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