| Description : |
Oncostatin M (OSM) is a pleitropic cytokine produced by activated T lymphocytes and monocytes that is structurally and functionally related to the subfamily of cytokines known as the IL-6-type cytokine family.?OSM either inhibits or enhances the growth of cells depending on cell type. It inhibits proliferation of skeletal muscle cells by blocking cell cycle progression from G(1) to S phase.?OSM is also a key mediator for proliferation and anti-apoptosis of hepatocytes which suggests that OSM gene therapy is useful, as preventive and curative means, for the treatment of patients with liver damage. |
| Source : |
E. coli |
| Species : |
Mouse |
| Form : |
This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. |
| Bio-activity : |
The biological activity of Mouse OSM was measured in a cell proliferation assay using NIH/3T3 mouse embryonic fibroblasts. The expected ED50= 0.25-1.0 ng/ml. |
| Molecular Mass : |
The predicted molecular weight of Recombinant Mouse OSM is Mr 21 kDa. |
| AA Sequence : |
manrgcsn sssqllsqlq nqanltgnte sllepyirlq nlntpdlraa ctqhsvafps edtlrqlskp hflstvyttl drvlyqldal rqkflktpaf pkldsarhni lgirnnvfcm arllnhslei peptqtdsga srstttpdvf ntkigscgfl wgyhrfmgsv grvfrewddg strsrr |
| Endotoxin : |
<0.1 eu/μg as determined by the lal> |
| Purity : |
>97% by SDS-PAGE and analyzed by silver stain. |
| Storage : |
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
