|Cat. No. :
||Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.
|Formulation/ Reconstitution :
||Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
||>95% as visualized by SDS-PAGE analysis.
|Amino Acid Sequence :
||FPMFKAGRCL CIGPGVKAVK VADIEKVSII HPSNNCDKTE VIVTLKAHKG RRCLNPKSKQ ANVIMKKVER MNFLRYQNV.
||The biological activity of recombinant swine CXCL11 was determined in a chemotaxis assay using a Boyden chamber with swine PBMC activated with PHA for 3 days followed by IL-2. Bioactivity is typically detected at 10 ng/mL.
|Stability And Storage :
||Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.