CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit
Cat.No. : | Kit-1713 |
Product Overview : | B7-2 (CD86) signaling through CTLA4(CD152) has been shown to inhibit T cell activation. This co-inhibitory pathway can be overactive in many tumors, enabling cancers to escape the host"s immune system. CTLA4-blocking antibodies, including Ipilimumab (Yervoy) and Tremelimumab, have shown clinical efficacy in treating cancer. |
- Specification
- Gene Information
- Related Products
Size : | 96 reactions |
Applications : | This kit is useful for screening for inhibitors of CTLA4 binding to B7-2. |
Storage : | Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival |
Products Types
◆ Recombinant Protein | ||
CTLA4-654M | Recombinant Mouse CTLA4 Protein, Fc-tagged | +Inquiry |
CTLA4-499H | Recombinant Human CTLA4 Protein (Met1-Phe162), HIgG1 Fc-tagged | +Inquiry |
CTLA4-656R | Recombinant Rabbit CTLA4 Protein, Fc-tagged | +Inquiry |
Ctla4-06M | Active Recombinant Mouse Ctla4 Protein, hIgG/His-tagged | +Inquiry |
CTLA4-109C | Active Recombinant Cynomolgus/Rhesus CTLA4 protein(Met1-Asp161), His-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-1047CCL | Recombinant Cynomolgus CTLA4 cell lysate | +Inquiry |
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
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