"PKM" Related Products


Recombinant Human PKM2, His-tagged

Cat.No. : PKM2-572H
Product Overview : Recombinant Human full length Pyruvate kinase M2 (PKM2) also known as PKM1/M2, isoform a (GenBank Accession No. NM_002654), fused with N-terminal His-tag, was expressed in an E. coli expression system.
Description : PKM1 and PKM2 are different splicing products of the PKM gene (exon 9 for PKM1 and exon 10 for PKM2). The M1 isoform (PKM1) is expressed in muscle and brain, and the M2 isoform is expressed during embryogenesis, in adipose tissue and pancreatic islets, and is the predominant form found in cancer cells.
Source : E. coli
Species : Human
Tag : His
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 200 mM imidazole
Bio-activity : ≥39 pmoles/min/µg.
Molecular Mass : 58.9 kDa
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80°C
Gene Name : PKM pyruvate kinase, muscle [ Homo sapiens (human) ]
Official Symbol : PKM
Synonyms : PKM; pyruvate kinase, muscle; PK3; PKM; TCB; OIP3; CTHBP; THBP1; MGC3932; Pyruvate kinase isozymes M1/M2; EC; Pyruvate kinase muscle isozyme; Pyruvate kinase 2/3; Cytosolic thyroid hormone-binding protein; Cytosolic thyroid hormone-bin ding protein; OPA-interacting protein 3; PK, muscle type; pyruvate kinase, muscle; thyroid hormone-binding protein, cytosolic
Gene ID : 5315
mRNA Refseq : NM_002654
Protein Refseq : NP_002645
MIM : 179050
UniProt ID : P14618
Chromosome Location : 15q22
Pathway : Adenine ribonucleotide biosynthesis, IMP => ADP,ATP; Biosynthesis of amino acids; Glycogen storage diseases
Function : ATP binding; MHC class II protein complex binding; magnesium ion binding

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