Cat. No. :	FASLG-5412H
Product Overview :	Recombinant Human soluble Fas Ligandcontains 175 amino acid residues and comprises the TNF homologous region ofFast plus an eight His-Tag.
Description :	FASLG is a type-IItransmembrane protein that belongs to the tumor necrosis factor (TNF) family.Its binding with its receptor induces apoptosis. Fas ligand/receptorinteractions play an important role in the regulation of the immune systemand the progression of cancer.
Source :	CHO cells
Species :	Human
Form :	Lyophilized withoutadditives.
Molecular Weight :	17.9 kDa
Purity :	<95% by RP-HPLC and SDS-PAGE.
Endotoxin Level :	<0.1 ng/ug
Biological Activity :	Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is <10.0 ng/ml.
Specific Activity :	< 1 x 105units/mg
Reconstitution :	Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
Storage :	Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles.
OfficialSymbol :	FASLG

Gene Name :	FASLG Fas ligand (TNFsuperfamily, member 6) [ Homo sapiens ]
Synonyms :	FASLG; Fas ligand(TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand;apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand)superfamily, member 6
Gene ID :	356
mRNA Refseq :	NM_000639
Protein Refseq :	NP_000630
MIM :	134638
UniProt ID :	P48023
Chromosome Location :	1q23
Pathway :	Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from procaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus
Function :	cytokine activity;protein binding; receptor binding; tumor necrosis factor receptor binding

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