| Cat. No. : |
MATK-5451H |
| Product Overview : |
Recombinant humanfull length MATK, His-tagged. No special measures were taken to activate thiskinase. |
| Description : |
MATK encoded bythis gene has amino acid sequence similarity to Csk tyrosine kinase and hasthe structural features of the CSK subfamily: SRC homology SH2 and SH3domains, a catalytic domain, a unique N terminus, lack of myristylationsignals, lack of a negative regulatory phosphorylation site, and lack of anautophosphorylation site. This protein is thought to play a significant rolein the signal transduction of hematopoietic cells. It is able tophosphorylate and inactivate Src family kinases, and may play an inhibitoryrole in the control of T-cell proliferation. This protein might be involvedin signaling in some cases of breast cancer. Three alternatively splicedtranscript variants that encode different isoforms have been described forthis gene. |
| Source : |
E. coli |
| Species : |
Human |
| Form : |
Liquid in 20 mMHEPES, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.5 mM EGTA + 0.05% CHAPS + 5 mMDTT + 50% glycerol |
| Molecular Weight : |
53.0 kDa |
| Concentration : |
0.4 mg/ml |
| Purity : |
≥ 90% as determinedby SDS-PAGE analysis |
| Specific Activity : |
490 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 4 µg/ml. |
| Storage : |
Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
| OfficialSymbol : |
MATK |
