Recombinant Human Megakaryocyte-Associated Tyrosine Kinase, His-tagged

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Recombinant Human Megakaryocyte-Associated Tyrosine Kinase, His-tagged

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Cat. No. : MATK-5451H
Product Overview : Recombinant humanfull length MATK, His-tagged. No special measures were taken to activate thiskinase.
Description : MATK encoded bythis gene has amino acid sequence similarity to Csk tyrosine kinase and hasthe structural features of the CSK subfamily: SRC homology SH2 and SH3domains, a catalytic domain, a unique N terminus, lack of myristylationsignals, lack of a negative regulatory phosphorylation site, and lack of anautophosphorylation site. This protein is thought to play a significant rolein the signal transduction of hematopoietic cells. It is able tophosphorylate and inactivate Src family kinases, and may play an inhibitoryrole in the control of T-cell proliferation. This protein might be involvedin signaling in some cases of breast cancer. Three alternatively splicedtranscript variants that encode different isoforms have been described forthis gene.
Source : E. coli
Species : Human
Form : Liquid in 20 mMHEPES, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.5 mM EGTA + 0.05% CHAPS + 5 mMDTT + 50% glycerol
Molecular Weight : 53.0 kDa
Concentration : 0.4 mg/ml
Purity : ≥ 90% as determinedby SDS-PAGE analysis
Specific Activity : 490 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 4 µg/ml.
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : MATK
Gene Name : MATKmegakaryocyte-associated tyrosine kinase [ Homo sapiens ]
Synonyms : MATK;megakaryocyte-associated tyrosine kinase; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK;MGC1708; MGC2101; DKFZp434N1212; megakaryocyte-associated tyrosine-proteinkinase; protein kinase HYL; HYL tyrosine kinase; tyrosine kinase MATK;Csk-homologous kinase; tyrosylprotein kinase; hydroxyaryl-protein kinase; tyrosine-proteinkinase CTK; Csk-type protein tyrosine kinase; leukocyte carboxyl-terminal srckinase related; hematopoietic consensus tyrosine-lacking kinase; EC 2.7.10.2
Gene ID : 4145
mRNA Refseq : NM_139354
Protein Refseq : NP_647611
MIM : 600038
UniProt ID : P42679
Chromosome Location : 19p13.3
Pathway : IL-3 SignalingPathway; Kit Receptor Signaling Pathway; Neurotrophic factor-mediated Trkreceptor signaling; Neurotrophin signaling pathway; Signaling events mediatedby Stem cell factor receptor (c-Kit)
Function : ATP binding;non-membrane spanning protein tyrosine kinase activity; nucleotide binding;protein tyrosine kinase activity

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