Recombinant Human Megakaryocyte-Associated Tyrosine Kinase, His-tagged
Cat.No. : | MATK-5451H |
Product Overview : | Recombinant humanfull length MATK, His-tagged. No special measures were taken to activate thiskinase. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MATK-5451H |
Description : | MATK encoded bythis gene has amino acid sequence similarity to Csk tyrosine kinase and hasthe structural features of the CSK subfamily: SRC homology SH2 and SH3domains, a catalytic domain, a unique N terminus, lack of myristylationsignals, lack of a negative regulatory phosphorylation site, and lack of anautophosphorylation site. This protein is thought to play a significant rolein the signal transduction of hematopoietic cells. It is able tophosphorylate and inactivate Src family kinases, and may play an inhibitoryrole in the control of T-cell proliferation. This protein might be involvedin signaling in some cases of breast cancer. Three alternatively splicedtranscript variants that encode different isoforms have been described forthis gene. |
Source : | E. coli |
Species : | Human |
Form : | Liquid in 20 mMHEPES, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.5 mM EGTA + 0.05% CHAPS + 5 mMDTT + 50% glycerol |
Molecular Weight : | 53.0 kDa |
Concentration : | 0.4 mg/ml |
Purity : | ≥ 90% as determinedby SDS-PAGE analysis |
Specific Activity : | 490 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 4 µg/ml. |
Storage : | Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | MATK |
Gene Name : | MATKmegakaryocyte-associated tyrosine kinase [ Homo sapiens ] |
Synonyms : | MATK;megakaryocyte-associated tyrosine kinase; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK;MGC1708; MGC2101; DKFZp434N1212; megakaryocyte-associated tyrosine-proteinkinase; protein kinase HYL; HYL tyrosine kinase; tyrosine kinase MATK;Csk-homologous kinase; tyrosylprotein kinase; hydroxyaryl-protein kinase; tyrosine-proteinkinase CTK; Csk-type protein tyrosine kinase; leukocyte carboxyl-terminal srckinase related; hematopoietic consensus tyrosine-lacking kinase; EC 2.7.10.2 |
Gene ID : | 4145 |
mRNA Refseq : | NM_139354 |
Protein Refseq : | NP_647611 |
MIM : | 600038 |
UniProt ID : | P42679 |
Chromosome Location : | 19p13.3 |
Pathway : | IL-3 SignalingPathway; Kit Receptor Signaling Pathway; Neurotrophic factor-mediated Trkreceptor signaling; Neurotrophin signaling pathway; Signaling events mediatedby Stem cell factor receptor (c-Kit) |
Function : | ATP binding;non-membrane spanning protein tyrosine kinase activity; nucleotide binding;protein tyrosine kinase activity |
Products Types
◆ Recombinant Protein | ||
MATK-3253R | Recombinant Rat MATK Protein, His (Fc)-Avi-tagged | +Inquiry |
Matk-3970M | Recombinant Mouse Matk Protein, Myc/DDK-tagged | +Inquiry |
Matk-1767M | Recombinant Mouse Matk Protein, His&GST-tagged | +Inquiry |
MATK-5386M | Recombinant Mouse MATK Protein, His (Fc)-Avi-tagged | +Inquiry |
MATK-50H | Recombinant Human MATK Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
MATK-4450HCL | Recombinant Human MATK 293 Cell Lysate | +Inquiry |
MATK-4451HCL | Recombinant Human MATK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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