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Active Recombinant Human Integrin-binding Sialoprotein, His-tagged

Cat.No. : IBSP-2711H
Product Overview : Recombinant Human Bone Sialoprotein (Phe17­Gln317) fused a His-tag at C-terminal was expressed in CHO cells.
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Cat. No. : IBSP-2711H
Description : Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum.
Source : CHO Cells
Species : Human
Predicted NTerminal : Phe17
SDS-PAGE : 75­90 kDa, reducing conditions
Activity : Measured by the ability of the immobilized protein to support the adhesion of the MCF-7human breast cancer cells. When 5 x104 cells/well are added to recombinant human IBSP- coated plates (3 µg/mL with 100 µL/well), approximately 60-80% will l adhereafter 30 minutes at 37°C.
Endotoxin : Less than 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS­PAGE under reducing conditions and visualized by silver stain.
Formulation : Lyophilized from a 0.2 μm filtered solution in MES and NaCl. See Certificate of Analysis for details.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Storage : 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. Avoid repeated freeze¬thaw cycles.
Gene Name : IBSP integrin-binding sialoprotein [ Homo sapiens ]
Official Symbol : IBSP
Synonyms : integrin-binding sialoprotein; BSP; BNSP; SP-II; BSP-II; IBSP; bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein; Cell-binding sialoprotein; Bone sialoprotein II
Gene ID : 3381
mRNA Refseq : NM_004967
Protein Refseq : NP_004958
MIM : 147563
UniProt ID : P21815
Chromosome Location : 4q21-q25
Pathway : ECM-receptor interaction; Focal adhesion; Integrin cell surface interactions

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any genetic variations in the IBSP gene associated with bone disorders? 06/10/2022

Yes, mutations in the IBSP gene have been linked to certain inherited bone diseases, highlighting the genetic basis of IBSP protein-related pathologies.

How is IBSP protein related to orthopedic surgery? 05/01/2022

IBSP protein is implicated in bone healing and regeneration, making it relevant in orthopedic surgeries for the treatment of fractures and bone defects.

Can IBSP protein be used as a prognostic marker for bone-related diseases? 04/25/2022

Yes, elevated or reduced levels of IBSP protein can serve as prognostic indicators for conditions such as osteoporosis and bone metastasis.

What role does IBSP protein play in dental medicine? 02/08/2018

IBSP protein is involved in the mineralization of dental tissues and can serve as a biomarker for dental diseases such as periodontitis and dental caries.

How is IBSP protein utilized in the development of therapeutic interventions? 05/25/2017

IBSP protein is a potential target for the development of novel therapies for bone disorders, as modulating its expression or activity can influence bone formation and remodeling.

Customer Reviews (3)

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Reviews
01/27/2023

    In addition to its impeccable quality, the manufacturer of the IBSP protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.

    03/01/2020

      Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

      10/03/2016

        The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.

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