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| Cat. No.: | TLR4-290H |
| Product Overview: | Recombinanthuman TLR4(Glu24-Lys631) protein, fused with C-terminal Ser and 10-His tag,was expressed in Mouse myeloma NS0cells. |
| Description: | The protein encoded by this gene is a member of the Toll-likereceptor (TLR) family which plays a fundamental role in pathogen recognitionand activation of innate immunity. TLRs are highly conserved from Drosophilato humans and share structural and functional similarities. They recognizepathogen-associated molecular patterns (PAMPs) that are expressed oninfectious agents, and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibit different patternsof expression. This receptor is most abundantly expressed in placenta, and inmyelomonocytic subpopulation of the leukocytes. It has been implicated insignal transduction events induced bylipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations inthis gene have been associated with differences in LPS responsiveness. Also,several transcript variants of this gene have been found, but the proteincoding potential of most of them is uncertain. |
| Source: | NS0 Cells |
| Form: | Lyophilizedfrom a 0.2 μm filtered solution in 100μg/mL PBS. |
| Activity: | Measuredby its binding ability in a functional ELISA. When Recombinant Human(rh) TLR4is immobilized at 2μg/mL(100μL/well), the concentration of rhMD2 thatproduces 50% optimal binding response is found to be approximately 0.03-0.15μg/mL. |
| Endotoxin Level: | <1.0EU per 1μg of the protein by the LAL method. |
| Molecular Weight: | The predicted molecular mass is 70.6kDa. |
| Purity: | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Shipping: | Theproduct is shipped at ambient temperature. Upon receipt, store it immediatelyat the temperature recommended below. |
| Storage: | Use a manual defrost freezer and avoid repeated freeze-thawcycles. 12 months from date of receipt, -20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 3 months, -20°C to-70°C under sterile conditions after reconstitution. |
| Gene Name: | TLR4 toll-like receptor 4 [ Homo sapiens] |
| Official Symbol: | TLR4 |
| Synonyms: | TLR4; toll-like receptor 4; TOLL; CD284; TLR-4; ARMD10; toll-like receptor 4; hToll; homolog of Drosophila toll; CD284antigen; OTTHUMP00000022807 |
| Gene ID: | 7099 |
| mRNA Refseq: | NM_003266 |
| Protein Refseq: | NP_003257 |
| MIM: | 603030 |
| UniProt ID: | O00206 |
| Chromosome Location: | 9q33.1 |
| Pathway: | Activated TLR4 signalling; Amoebiasis; IKK complex recruitmentmediated by RIP1; Immune System; Influenza A; Innate Immune System; Leishmaniasis;MyD88 cascade initiated on plasma membrane; Pathogenic Escherichia coliinfection; Pertussis; Rheumatoid arthritis; TRAF6 mediated induction of TAK1complex; Toll Like Receptor 10 (TLR10) Cascade; Toll Like Receptor 2 (TLR2)Cascade; Toll Receptor Cascades; Toll-like receptor signaling pathway |
| Function: | lipopolysaccharide binding; lipopolysaccharide receptor activity;phosphatidylinositol 3-kinase binding; protein binding; receptor activity; embranesignaling receptor activity |
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