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Recombinant Human ADIPOQ, Fc-tagged

Cat.No.: ADIPOQ-7301H
Product Overview: A DNA sequence encoding the Human ADIPOQ (Met1-Asn244) was expressed in Human Cells, with the Fc region of Human IgG1 at the C-terminus.
Description: Adiponectin (ADIPOQ), also known as Adipocyte, C1q and collagen domain-containing protein, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, gelatin-binding protein, ADIPOQ and ACDC, is a secreted protein which contains oneC1q domain and onecollagen-like domain. Adiponectin/Acrp30/ADIPOQ is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin/Acrp30/ADIPOQ stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin/Acrp30/ADIPOQ antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Adiponectin/Acrp30/ADIPOQ inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Source: Human Cells
Species: Human
Tag: Fc
Predicted N Terminal: Glu 19
Form: Lyophilized from a 0.2μM filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass: The recombinant protein is a disulfide-linked homodimer. The reduced monomer comprises 467 amino acids and has a predicted molecular mass of 51.6 kDa. The apparent molecular mass of the protein is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
Endotoxin: 1.0 eu/μg of the protein as determined by the lal
Purity: >97 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name: ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens ]
Official Symbol: ADIPOQ
Synonyms: ADIPOQ; adiponectin, C1Q and collagen domain containing; ACDC, adipocyte, C1Q and collagen domain containing; adiponectin; ACRP30; AdipoQ; adipose most abundant gene transcript 1; apM1; GBP28; gelatin-binding protein 28; adipose specific collagen-like factor; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipose most abundant gene transcript 1 protein; ACDC; ADPN; APM1; APM-1; ADIPQTL1;
Gene ID: 9370
mRNA Refseq: NM_001177800
Protein Refseq: NP_001171271
MIM: 605441
UniProt ID: Q15848
Chromosome Location: 3q27
Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Developmental Biology, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem; PPAR signaling pathway, conserved biosystem; Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem;
Function: cytokine activity; eukaryotic cell surface binding; hormone activity; identical protein binding; protein binding; protein homodimerization activity; receptor binding; sialic acid binding;

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