ADIPOQ
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Official Full Name
adiponectin, C1Q and collagen domain containing
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Overview
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. -
Synonyms
ADIPOQ; adiponectin, C1Q and collagen domain containing; APN; Acdc; apM1; 30kDa; GBP28; adipo; Acrp30; adiponectin; adipocyte-specific protein AdipoQ; adipocyte complement related protein; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cattle
- Chicken
- Dog
- Gln48-Asn274
- Horse
- Human
- Mouse
- Pig
- Porcine
- Rabbit
- Rat
- Rhesus Macaque
- C-His
- CHO
- E.coli
- HEK293
- HEK293 cells
- HEK293F
- HEK293T
- Human
- Human Cell
- Human cells
- Human Serum
- Insect cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Porcine
- Wheat Germ
- Yeast
- C
- hFc
- Fc
- Flag
- GST
- His
- HIS
- Avi
- S
- SUMO
- T7
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ADIPOQ involved in several pathways and played different roles in them. We selected most pathways ADIPOQ participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADIPOQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | MMP1;AQP7;ACSL1;ACOX1;GK2;PDPK1B;LPL;SLC27A1A;ACOX2 |
| AMPK signaling pathway | PPP2R2A;MLYCD;PPP2R2D;TSC1;AKT1S1;CREB3L1;HMGCR;IRS2;EEF2K |
| Adipocytokine signaling pathway | RXRGA;SOCS3B;G6PC;G6PCA.2;ACSL5;PPARA;NFKBIB;CAMKK2;ACSBG2 |
| Type II diabetes mellitus | PKM2;PIK3CD;SLC2A4;HKDC1;SOCS1;IRS4;PIK3R2;IRS1;INS1 |
| Non-alcoholic fatty liver disease (NAFLD) | FASLG;SDHD;IL6;NDUFA6;COX4I2;NDUFA12;NR1H3;NDUFB2;GSK3B |
ADIPOQ has several biochemical functions, for example, cytokine activity, hormone activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADIPOQ itself. We selected most functions ADIPOQ had, and list some proteins which have the same functions with ADIPOQ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IL4;BMP4;GDF3;IL16;GM13287;RNF207B;IL29;IL20;IL17A |
| hormone activity | PRL2C2;RETNLB;URP2;NPPB;PRL8A9;STC1L;LHB;SST;UTS1 |
| identical protein binding | SDF4;C10orf88;AGER;PYCARD;TRA@;TPD52L1;E2F7;PRKD1;SAFB2 |
| protein binding | LIG4;RHO;NAT8B;PPIH;STK25;COPRS;NLK;KIF4A;PDGFRB |
| protein homodimerization activity | CER1;BHLHE40;P2RX7;LDB1;HMGCR;VPS25;EEA1;MYO7A;ATPIF1A |
| receptor binding | SRPX2;MYO1C;CD58;RND1;NPFF;TYROBP;CCL17;FGF20A;LAMA1 |
| sialic acid binding | L1CAM;AGRN;ST8SIA2;Siglece;SELP;ST8SIA3;ADIPOQ;FCN1;SELE |
ADIPOQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADIPOQ here. Most of them are supplied by our site. Hope this information will be useful for your research of ADIPOQ.
C1QTNF9B; C1QTNF9
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (5)
Write a reviewthe quality of the ADIPOQ protein used in experiments is of utmost importance and can significantly impact the accuracy and reliability of the results obtained.
The packaging and shipping of the protein were both efficient and effective, ensuring that the product arrived in good condition and ready to use.
The protein's stability and shelf-life have exceeded my expectations, allowing me to use it for multiple experiments without worrying about degradation or loss of potency.
In this regard, using a protein of very high quality that meets your experimental needs is essential.
It will ensure that your results are both valid and reproducible, providing you with valuable insights into the expression and function of ADIPOQ.
Q&As (12)
Ask a questionThere is limited research on the use of ADIPOQ proteins in cancer treatment. However, some studies have suggested that ADIPOQ proteins may have a protective effect against certain types of cancers, including breast, colon, and prostate cancer.
Various conditions and diseases can affect ADIPOQ protein levels, including type 2 diabetes, obesity, metabolic syndrome, polycystic ovary syndrome, and certain cancers.
Yes, ADIPOQ levels can be modulated through lifestyle changes. Regular exercise and weight loss can increase ADIPOQ levels in the blood, while a diet high in saturated fats and sugar can decrease ADIPOQ levels.
Yes, ADIPOQ proteins have been shown to have a protective effect on cardiovascular health. High levels of ADIPOQ proteins are associated with lower risk of cardiovascular disease, while low levels of ADIPOQ proteins are associated with increased risk.
Lifestyle changes such as diet and exercise can significantly affect ADIPOQ protein levels. Eating a healthy diet and maintaining a healthy weight can increase circulating levels of ADIPOQ proteins, while sedentary lifestyle and obesity can decrease ADIPOQ protein levels.
Low levels of ADIPOQ proteins in the circulation have been associated with obesity and an increased risk of metabolic disorders such as insulin resistance and type 2 diabetes. High levels of ADIPOQ proteins, on the other hand, have been associated with better insulin sensitivity and a lower risk of metabolic disorders.
Some medications, such as thiazolidinediones (TZDs), commonly used to treat type 2 diabetes, can increase ADIPOQ levels and improve insulin sensitivity. However, other medications, such as glucocorticoids, used to treat inflammatory conditions, can reduce ADIPOQ levels and worsen insulin resistance.
ADIPOQ protein levels can be measured in the circulation using a blood test or through adipose tissue biopsies. The blood test is a more commonly used diagnostic tool to evaluate ADIPOQ protein levels due to its non-invasive nature.
Yes, measuring circulating levels of ADIPOQ proteins can be used as a biomarker for metabolic disorders such as insulin resistance and type 2 diabetes. Low levels of ADIPOQ proteins are associated with an increased risk of these disorders.
Currently, there are no medications that target ADIPOQ proteins directly. However, drugs that improve insulin sensitivity and metabolic function, such as thiazolidinediones (TZDs) and metformin, have been shown to increase circulating levels of ADIPOQ proteins.
As research continues to explore the role of ADIPOQ proteins in various physiological processes, they may have potential future applications for the prevention and treatment of metabolic disorders, cardiovascular disease, infertility, and certain types of cancer. Additionally, ADIPOQ proteins may serve as a biomarker for disease and treatment response.
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