Recombinant Human IDO1, His-tagged IDO1-7190H

Recombinant Human IDO1, His-tagged


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Recombinant Human IDO1, His-tagged

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Cat. No. : IDO1-7190H
Product Overview : Recombinant Human IDO1 (indoleamine 2,3-dioxygenase) (Ala2­Gly403) fused with 6*His tag at N-terminal, was expressed in E. coli.
Description : Indoleamine 2,3-dioxygenase(IDO) is a heme-containing intracellular dioxygenase catalyzing the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. This degradation is the first and rate-limiting step of the L-kynurenine pathway. IDO is widely expressed in dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. In immune cells, its expression is mainly induced by cytokines such as IFN-γ, IFN-α, IFN-β, and IL-10. IDO has an antimicrobial function due to its decreasing the availability of the essential amino acid tryptophan in inflammatory environments. Recent studies have demonstrated that IDO induces immunosuppression during infection, pregnancy, transplantation, autoimmunity, and neoplasia.
Source : E. coli
Molecular Mass : The predicted molecular mass is 46 kDa. The apparent molecular mass of the protein is approximately 42 kDa in SDS-PAGE under reducing conditions.
Predicted N terminal : Met
Formulation : Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl and Glycerol.
Purity : >95% as determined by SDS­PAGE
Bio-Activity : Measured by its ability to oxidize L­tryptophan to N­formyl­kynurenine. The specific activity is >500 pmol/min/μg.
EndotoxinLevel : <1.0 EU per 1 μg of the protein by the LAL method.
Storage : 6 months from date of receipt, ­70 °C as supplied. Avoid repeated freeze/thaw cycles.
OfficialSymbol : IDO1
Gene Name : IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens ]
Synonyms : IDO1; indoleamine 2,3-dioxygenase 1; IDO; INDO; IDO-1; indoleamine 2,3-dioxygenase 1; EC; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; Indoleamine-pyrrole 2
Gene ID : 3620
mRNA Refseq : NM_002164
Protein Refseq : NP_002155
MIM : 147435
UniProt ID : P14902
Chromosome Location : 8p12-p11
Pathway : African trypanosomiasis; Metabolism of amino acids and derivatives; Tryptophan catabolism; tryptophan degradation XI (mammalian, via kynurenine)
Function : electron carrier activity; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; oxygen binding; tryptophan 2,3-dioxygenase activity; amino acid binding

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