Recombinant Mouse Indoleamine 2,3-dioxygenase 1, His-tagged
Cat.No. : | Ido1-2126M |
Product Overview : | Recombinant Mouse Ido1 was produced inE. coli.Mature mouse IDO (indoleamine 2,3-dioxygenase) (aa 1-407) is fused at the C-terminus to a His-tag. |
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Cat. No. : | Ido1-2126M |
Description : | Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). IDO is the first and rate-limiting enzyme of tryptophan catabolism through kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells. |
Source : | E. coli. |
Purity : | ≥90% (SDS-PAGE). |
Formulation : | Liquid. 0.2µm-filtered solution in 50mM TRIS, pH 7.4, containing 1mM EDTA. |
Concentration : | 1mg/ml. |
Endotoxin Content : | <1EU/µg protein (LAL-test). |
Specific Activity : | >100'000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour. |
Storage : | Working aliquots are stable for up to 3 months when stored at -20°C. |
Gene Name : | Ido1 indoleamine 2,3-dioxygenase 1 [ Mus musculus ] |
Synonyms : | Ido1; indoleamine 2,3-dioxygenase 1; Ido; Indo; IDO-1; OTTMUSP00000022551; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; EC 1.13.11.52 |
Gene ID : | 15930 |
mRNA Refseq : | NM_008324 |
Protein Refseq : | NP_032350 |
UniProt ID : | P28776 |
Chromosome Location : | 8 A2 |
Pathway : | Metabolic pathways; Tryptophan metabolism |
Function : | amino acid binding; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; oxygen binding; tryptophan 2,3-dioxygenase activity |
Products Types
◆ Recombinant Protein | ||
IDO1-4414M | Recombinant Mouse IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IDO1-2645R | Recombinant Rat IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IDO1-085H | Recombinant Human IDO1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
IDO1-2077M | Recombinant Mouse IDO1 Protein (1-407 aa), His-tagged | +Inquiry |
IDO1-3829H | Recombinant Human IDO1 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
IDO1-5300HCL | Recombinant Human IDO1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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