Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CYP2E1and Yeast CYP-reductase

Cat.No. : CYP2E1-219H
Product Overview : Recombinant Human CYP2E1 and yeast CYP-reductase coexpressed in Saccharomyces cerevisiae.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : CYP2E1-219H
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Source : Saccharomyces cerevisiae
Storage buffer : 50 mM Tris (pH 7.4), 1 mM EDTA, 20 % glycerol
concentration : 1nmol/ml, spectral measurement
Activitymeasured : p-nitrophenol hydroxylase
Storage : −80°C. Avoid frequent temperature changes. Thaw on ice.
OfficialSymbol : CYP2E1
Gene Name : CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 [ Homo sapiens ]
Synonyms : cytochrome P450, family 2, subfamily E, polypeptide 1; CPE1; CYP2E; P450-J; P450C2E; CYP2E1; cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; microsomal monooxygenase; xenobiotic monooxygenase; 4-nitrophenol 2-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; EC 1.14.13.-,EC 1.14.13.n7
Gene ID : 1571
mRNA Refseq : NM_000773
Protein Refseq : NP_000764
MIM : 124040
UniProt ID : P05181
Chromosome Location : 10q24.3-qter
Pathway : Arachidonic acid metabolism; Drug metabolism - cytochrome P450; Linoleic acid metabolism; Metabolic pathways; Metabolism of xenobiotics by cytochrome P450; Biological oxidations
Function : electron carrier activity; enzyme binding; heme binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there known genetic polymorphisms in CYP2E1 associated with altered drug metabolism or disease risk? 05/03/2022

Genetic polymorphisms in CYP2E1 can result in altered enzyme activity, influencing an individual's response to drugs and susceptibility to liver damage.

What is the main function of CYP2E1 in drug metabolism? 10/19/2021

CYP2E1 oxidizes and metabolizes various small molecules, including drugs and toxins.

How does CYP2E1 contribute to the metabolism of ethanol and other toxins? 02/27/2021

It plays a significant role in ethanol metabolism and helps detoxify industrial solvents and other xenobiotics.

What factors can induce the expression of CYP2E1? 08/08/2020

Ethanol, fasting, and certain drugs can induce the expression of CYP2E1.

How is CYP2E1 linked to the generation of reactive oxygen species (ROS)? 11/15/2019

CYP2E1 activity generates ROS, contributing to oxidative stress and potential cellular damage.

In which tissues is CYP2E1 predominantly expressed? 01/24/2019

CYP2E1 is highly expressed in the liver, which is the main site for drug metabolism.

What role does CYP2E1 play in drug-drug interactions? 08/05/2018

CYP2E1 can contribute to drug-drug interactions, affecting the efficacy and toxicity of co-administered drugs.

Customer Reviews (3)

Write a review
Reviews
07/04/2022

    Product is as described.

    04/12/2022

      Fast and efficient service.

      12/19/2020

        Great for biological experiments.

        Ask a Question for All CYP2E1 Products

        Required fields are marked with *

        My Review for All CYP2E1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends