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Recombinant Human Proopiomelanocortin

Cat.No. : POMC-339H
Description : Adrenocorticotropic hormone, as its name implies, stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. Stimulates secretion of adrenal corticosteroids and induces growth of adrenal cortex. ACTH also called Tetracosactide directly activates G-proteins. A stimulator of adenylate cyclase and cAMP formation. Its molecular weight is 4.541 kDa.
Species : Human
Form : Sterile filtered and lyophilized with no additives.
Molecular Mass : 4.541 kDa
AA Sequence : H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-P ro-Val-Lys-Val-Tyr-Pro-OH
Purity : ≥98% by SDS-PAGE and HPLC analyses.
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in sterile dW to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 2-7 days and at -20 °C for future use.
Gene Name : POMC proopiomelanocortin [ Homo sapiens ]
Official Symbol : POMC
Synonyms : POMC; proopiomelanocortin; pro-opiomelanocortin; ACTH; adrenocorticotropic hormone; adrenocorticotropin; alpha melanocyte stimulating hormone; beta endorphin; beta lipotropin; beta melanocyte stimulating hormone; CLIP; LPH; MSH; NPP; POC; beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin; met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta; melanotropin alpha; melanotropin gamma; pro-ACTH-endorphin; corticotropin-lipotropin; proopiomelanocortin preproprotein; beta-melanocyte-stimulating hormone; alpha-melanocyte-stimulating hormone; corticotropin-like intermediary peptide;
Gene ID : 5443
mRNA Refseq : NM_000939
Protein Refseq : NP_000930
MIM : 176830
UniProt ID : P01189
Chromosome Location : 2p23
Pathway : Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Androgen biosynthesis, organism-specific biosystem; Biological oxidations, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Endogenous sterols, organism-specific biosystem;
Function : G-protein coupled receptor binding; hormone activity; hormone activity; receptor binding; type 1 melanocortin receptor binding; type 1 melanocortin receptor binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding;

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