Recombinant Human Protein Kinase D2
Cat.No. : | PRKD2-1130H |
Product Overview : | Recombinant human PRKD2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PRKD2-1130H |
Description : | PRKD2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein which belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-710 and phosphorylation of Ser-706 by PKC relieves auto-inhibition by the PH domain. PRKD2 / PKD2 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress. |
Biological Activity : | 259 nmol phosphate incorporated into CREBtide substrate peptide per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay). |
Molecular Weight : | 130.0 kDa |
Source : | Sf9 insect cells |
Species : | Human |
Form : | Recombinant proteins in storage buffer (50 mMTris-HCl, pH 7.5, 150 mMNaCl, 0.25 mM DTT, 0.1 MmEGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol). |
Appearance : | Liquid |
Purity : | ≥80% by SDS-PAGE |
Storage : | Store product frozen at or below -70°C. Stable for 1 year at -70°C as undiluted stock. Aliquot to avoidrepeated thawing and freezing. |
Pathways : | T Cell Receptor Signaling Pathway |
Gene Name : | PRKD2 protein kinase D2 [ Homo sapiens ] |
Official Symbol : | PRKD2 |
Synonyms : | PRKD2; protein kinase D2; PKD2; HSPC187; serine/threonine-protein kinase D2; nPKC-D2; EC 2.7.11.13; DKFZP586E0820 |
Gene ID : | 25865 |
mRNA Refseq : | NM_001079880 |
Protein Refseq : | NP_001073349 |
MIM : | 607074 |
UniProt ID : | Q9BZL6 |
Chromosome Location : | 19q13.3 |
Function : | ATP binding; metal ion binding; nucleotide binding; protein kinase C activity; protein serine/threonine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
PRKD2-1156H | Recombinant Human PRKD2 Protein (A2-L878), Tag Free | +Inquiry |
PRKD2-2950H | Recombinant Human PRKD2 Protein, MYC/DDK-tagged | +Inquiry |
PRKD2-1157H | Recombinant Human PRKD2 Protein (A2-L878), His/GST tagged | +Inquiry |
Prkd2-186M | Recombinant Mouse Prkd2 Protein, MYC/DDK-tagged | +Inquiry |
PRKD2-7099M | Recombinant Mouse PRKD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PRKD2-644HCL | Recombinant Human PRKD2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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