"HDAC8" Related Products


Recombinant Human Histone Deacetylase 8

Cat. No.: HDAC8-1655H
Description: HDAC8 is a member of the class I Histone Deacetylases. HDAC8 are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDAC8 catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDAC8 have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).
Biological Activity: Activity of rh-HDAC8 was tested using Arg-His-Lys (Ac)-Ly (Ac)-AMC, a fluorogenic, acetylated peptide based on residues 379-382 of p53 as a substrate.
Molecular Weight: 44 kDa
Source: Sf9 insect cells
Species: Human
Form: Liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.
Appearance: Liquid
Purity: > 90% by SDS-PAGE
Storage: Stable for 1 year at -70°C. Avoid multipie freeze/thaw cycles as activity may decrease.
Pathways: Cell cycle; Signaling events mediated by HDAC Class I
Gene Name: HDAC8 histone deacetylase 8 [ Homo sapiens ]
Official Symbol: HDAC8
Synonyms: HDAC8; histone deacetylase 8; RPD3; HDACL1; histone deacetylase-like 1; EC; HD8
Gene ID: 55869
mRNA Refseq: NM_018486
Protein Refseq: NP_060956
MIM: 300269
UniProt ID: Q9BY41
Chromosome Location: Xq13
Function: histone deacetylase activity; hydrolase activity; transcription factor binding; metal ion binding; histone deacetylase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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