"HDAC8" Related Products


Recombinant Human Histone Deacetylase 8

Cat. No. : HDAC8-1655H
Description : HDAC8 is a member of the class I Histone Deacetylases. HDAC8 are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDAC8 catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDAC8 have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).
Biological Activity : Activity of rh-HDAC8 was tested using Arg-His-Lys (Ac)-Ly (Ac)-AMC, a fluorogenic, acetylated peptide based on residues 379-382 of p53 as a substrate.
Molecular Weight : 44 kDa
Source : Sf9 insect cells
Species : Human
Form : Liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.
Appearance : Liquid
Purity : > 90% by SDS-PAGE
Storage : Stable for 1 year at -70°C. Avoid multipie freeze/thaw cycles as activity may decrease.
Pathways : Cell cycle; Signaling events mediated by HDAC Class I
Gene Name : HDAC8 histone deacetylase 8 [ Homo sapiens ]
Official Symbol : HDAC8
Synonyms : HDAC8; histone deacetylase 8; RPD3; HDACL1; histone deacetylase-like 1; EC; HD8
Gene ID : 55869
mRNA Refseq : NM_018486
Protein Refseq : NP_060956
MIM : 300269
UniProt ID : Q9BY41
Chromosome Location : Xq13
Function : histone deacetylase activity; hydrolase activity; transcription factor binding; metal ion binding; histone deacetylase activity

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