Cat. No. : |
HDAC8-1655H |
Description : |
HDAC8 is a member of the class I Histone Deacetylases. HDAC8 are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDAC8 catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDAC8 have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA). |
Biological Activity : |
Activity of rh-HDAC8 was tested using Arg-His-Lys (Ac)-Ly (Ac)-AMC, a fluorogenic, acetylated peptide based on residues 379-382 of p53 as a substrate. |
Molecular Weight : |
44 kDa |
Source : |
Sf9 insect cells |
Species : |
Human |
Form : |
Liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol. |
Appearance : |
Liquid |
Purity : |
> 90% by SDS-PAGE |
Storage : |
Stable for 1 year at -70°C. Avoid multipie freeze/thaw cycles as activity may decrease. |
Pathways : |
Cell cycle; Signaling events mediated by HDAC Class I |