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| Cat. No.: | CDK2-999H |
| Product Overview: | Recombinant full-length human CDK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition. |
| Applications: | Western Blot |
| Molecular Weight: | 94 kDa |
| Expression System: | Sf9 insect cells using baculovirus |
| Species: | Human |
| Form: | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
| Specific Activity: | 31 nmol/min/mg |
| Purity: | > 80 % |
| Concentration: | 0.1 ug/ul |
| Sequences: | Full-length |
| Storage: | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways: | Activation of ATR in response to replication stress; Activation of the pre-replicative complex; B Cell Receptor Signaling Pathway; BARD1 signaling events; Cell Cycle Checkpoints; Cell Cycle; Cyclin E associated events during G1/S transition; DNA Replication; DNA Replication Pre-Initiation; Delta-Notch Signaling Pathway; E2F transcription factor network; FoxO family signaling; G2/M Checkpoints; Herpes simplex infection; Measles |
| Gene Name: | CDK2 cyclin-dependent kinase 2 [ Homo sapiens ] |
| Official Symbol: | CDK2 |
| Synonyms: | CDK2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; EC 2.7.11.22; cell devision protein kinase 2; CCNA2; p33(CDK2); cyclin A2; CCN1; CCNA; Cyclin-A; Cyclin-A2 |
| Gene ID: | 1017 |
| mRNA Refseq: | NM_001798 |
| Protein Refseq: | NP_001789 |
| MIM: | 116953 |
| UniProt ID: | P24941 |
| Chromosome Location: | 12q13 |
| Function: | ATP binding; cyclin binding; cyclin-dependent protein kinase activity; contributes_to histone kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity |
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