"CDK2" Related Products


Recombinant Human Cyclin-Dependent Kinase 2, GST-tagged

Cat. No. : CDK2-999H
Product Overview : Recombinant full-length human CDK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition.
Applications : Western Blot
Molecular Weight : 94 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Specific Activity : 31 nmol/min/mg
Purity : > 80 %
Concentration : 0.1 ug/ul
Sequences : Full-length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Activation of ATR in response to replication stress; Activation of the pre-replicative complex; B Cell Receptor Signaling Pathway; BARD1 signaling events; Cell Cycle Checkpoints; Cell Cycle; Cyclin E associated events during G1/S transition; DNA Replication; DNA Replication Pre-Initiation; Delta-Notch Signaling Pathway; E2F transcription factor network; FoxO family signaling; G2/M Checkpoints; Herpes simplex infection; Measles
Protein CDK2 PDB 1aq1. :

Gene Name : CDK2 cyclin-dependent kinase 2 [ Homo sapiens ]
Official Symbol : CDK2
Synonyms : CDK2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; EC; cell devision protein kinase 2; CCNA2; p33(CDK2); cyclin A2; CCN1; CCNA; Cyclin-A; Cyclin-A2
Gene ID : 1017
mRNA Refseq : NM_001798
Protein Refseq : NP_001789
MIM : 116953
UniProt ID : P24941
Chromosome Location : 12q13
Function : ATP binding; cyclin binding; cyclin-dependent protein kinase activity; contributes_to histone kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity

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