Recombinant Human Cyclin-Dependent Kinase 2, GST-tagged
Cat.No. : | CDK2-999H |
Product Overview : | Recombinant full-length human CDK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CDK2-999H |
Description : | CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition. |
Applications : | Western Blot |
Molecular Weight : | 94 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
Specific Activity : | 31 nmol/min/mg |
Purity : | > 80 % |
Concentration : | 0.1 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Activation of ATR in response to replication stress; Activation of the pre-replicative complex; B Cell Receptor Signaling Pathway; BARD1 signaling events; Cell Cycle Checkpoints; Cell Cycle; Cyclin E associated events during G1/S transition; DNA Replication; DNA Replication Pre-Initiation; Delta-Notch Signaling Pathway; E2F transcription factor network; FoxO family signaling; G2/M Checkpoints; Herpes simplex infection; Measles |
Gene Name : | CDK2 cyclin-dependent kinase 2 [ Homo sapiens ] |
Official Symbol : | CDK2 |
Synonyms : | CDK2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; EC 2.7.11.22; cell devision protein kinase 2; CCNA2; p33(CDK2); cyclin A2; CCN1; CCNA; Cyclin-A; Cyclin-A2 |
Gene ID : | 1017 |
mRNA Refseq : | NM_001798 |
Protein Refseq : | NP_001789 |
MIM : | 116953 |
UniProt ID : | P24941 |
Chromosome Location : | 12q13 |
Function : | ATP binding; cyclin binding; cyclin-dependent protein kinase activity; contributes_to histone kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity |
Products Types
◆ Recombinant Protein | ||
CDK2-1003H | Active Recombinant Human CDK2 Protein, GST-Tagged | +Inquiry |
CDK2/CyclinA2-272H | Recombinant Human CDK2/Cyclin A2, GST-tagged, Active | +Inquiry |
CDK2-3142H | Recombinant Human CDK2 Protein, MYC/DDK-tagged | +Inquiry |
CDK2-1000H | Recombinant Human CDK2 Protein, GST-Tagged | +Inquiry |
CDK2-726H | Recombinant Human CDK2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CDK2-708HCL | Recombinant Human CDK2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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