"FGFR1" Related Products

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Recombinant Human Fibroblast Growth Factor Receptor 1, GST-tagged

Cat. No.: FGFR1-4843H
Product Overview: Recombinant human FGFR1 (399-822; V561M) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body.
Applications: Kinase Assay; Western Blot
Molecular Weight: 75 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
Specific Activity: 32 nmol/min/mg
Purity: > 90 %
Concentration: 0.1 ug/ul
Sequences: 399-822; V561M
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: adherens junction; axon guidance; downstream signaling of activated FGFR; endochondral ossification; FGF signaling pathway; glypican 1 network; IRS-mediated signaling; Insulin receptor signalling cascade; L1CAM interactions
Gene Name: FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ]
Official Symbol: FGFR1
Synonyms: FGFR1; fibroblast growth factor receptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; FLJ99988; bFGF-R-1; basic fibroblast growth factor receptor 1; OTTHUMP00000190874; OTTHUMP00000190875; OTTHUMP00000190876; OTTHUMP00000190877; OTTHUMP00000190879; OTTHUMP00000190880; OTTHUMP00000190881; OTTHUMP00000190885; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor
Gene ID: 2260
mRNA Refseq: NM_023110
Protein Refseq: NP_075598
MIM: 136350
UniProt ID: P11362
Chromosome Location: 8p12
Function: ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; protein homodimerization activity; protein tyrosine kinase activity; receptor activity

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