Recombinant Human Fibroblast Growth Factor Receptor 1(IIIb)

• Cat.No.: FGFR1-485H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Fibroblast growth factor receptor-1 alpha (FGFR1-alpha) is an isoform of FGFR1 which is a receptor tyrosine kinase. FGFR1-alpha is expressed in prostate luminal epithelial cells. FGFR1alpha signals are posteriorizing factors that control node regression and posterior embryonic development. FGFR1-alpha is a splice variant of FGFR1 containing the first immunoglobulin-like domain, whereas FGFR1-beta lacks this domain. The presence or absence of this N-terminal domain influences the affinity of the receptor towards aFGF and heparin.
• Molecular Weight: The predicted molecular weight of Recombinant Human FGF R1α (IIIb) is Mr 66 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110-120 kDa.
• State Of Matter: Lyophilized.
• Purity: > 95% by SDS Page and analyzed by silver stain.
• Endotoxin: < 1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ]
• Synonyms: FGFR1; fibroblast growth factor receptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR; N-SAM; FLJ99988; OTTHUMP00000190881; soluble FGFR1 variant 1; FMS-like tyrosine kinase 2; ydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1
• Gene ID: 2260
• mRNA Refseq: NM_015850
• Protein Refseq: NP_056934
• UniProt ID: P11362
• Chromosome Location: 8p12
• MIM: 607401
• Pathway: Adherens junction; MAPK signaling pathway; elanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Axon guidance; Signaling by FGFR
• Function: ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; transferase activity